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Biomedical subjects

S Morii

Publications and source records attributed to S Morii.

At least 109 records · Page 6Linked to original sources
PubMed1981

Morphologic characteristics of pregnancy-dependent mammary tumors in GRS/A mice.

Groups of pregnancy-dependent mammary tumors from GRS/A female mice, composed of early, maximally grown and regressed tumors, were investigated morphologically in comparison with functionally active normal mammary gland of the same host and pregnancy-independent mammary tumors of the same strain. In the dependent tumors, earlier ones consisted of proliferating, non-secretory ductular cells in loose stroma, which grotesquely resembled normal mammary gland architecture, and the maximally grown feature was the localized overgrowth of the ductal lobular unit, in which papillomatous proliferations of ductal structures were observed. Histochemically, few myoepithelial cells in the tumours, low secretory activity and poor expression of murine mammary tumor virus antigens in these tumor cells were detected, as contrasted with neighboring mammary glands of pregnant and lactating mice. Particularly severe necrosis occurred in the papillomatous foci of ductal elements within the dependent tumors soon after parturition, and these finally changed to a group of microcysts. Small foci of adenocarcinoma type B were rarely seen in the dependent tumors during later pregnancies, and some cancer cells showed an intracytoplasmic focal staining for the viral antigens. Such an immunohistochemical finding was never detected in the dependent tumors.

Adenocarcinoma↗
PubMed1980

Diffuse alveolar septal amyloidosis in generalised amyloidosis.

A case of generalized amyloidosis is reported which diffusely involved the alveolar septa. A 67-year-old Japanese housewife showed no clinical evidence of systemic disease. She had complained of anorexia and diarrhea for a year and finally died of pneumonia-like symptom. Autopsy revealed a generalized amyloidosis, in which amyloid materials deposited beneath the basement membrane prominently in alveolar septa, and slightly in glands of alimental tract, thyroid and kidneys, perireticularly in the myocardium and adipose tissues, focally in the interstitial spaces of urogenital tract, thyroid, eosphagus and pancreas, and within the walls of small blood vessels in many organs No amyloid tumor was detected in the respiratory system. Severe alveolar septal amyloidosis occurred diffusely in both lungs in this case. The arrangement of amyloid deposition in the lungs was discussed in relation to gas diffusion in the alveolar walls.

Aged↗
PubMed1978

Male prolactin secreting pituitary adenomas in humans studied by peroxidase-labelled antibody method.

In order to identity the source of excess secretion of prolactin in male patients, the pituitary tumors of 11 males with hyperprolactinaemia were studied by peroxidase-labelled antibody method using antibodies against human prolactin. Using light microscope, prolactin was demonstrated in most tumour cells in all cases. Ultrastructurally, prolactin was localized mainly on the secretory granules. Immunohistochemically positive cells were thought to correlate with first type of tumour cells which were the major component observed by regular electron microscopic study without immunohistochemical staining. These findings indicated the secretion of excess amount of prolactin by the tumour cells and were considered to be responsible for the category of Male Prolactin Secreting Pituitary Adenoma. The mechanism by which these male hyperprolactinaemic patients are endocrinologically non-functioning is also discussed.

Adenoma, Chromophobe↗
PubMed1977

[A case of spontaneous 3rd ventriculostomy (author's transl)].

We have reported a rare case of spontaneous 3rd ventriculostomy with spontaneous arrest of obstructive hydrocephalus. A 41 year old man, who had had an intermittent headache for about a year, was admitted to the department of neurosurgery Kitasato University with chief complaints of sudden onset of severe headache, vomiting and disturbance of consciousness. At the time of admission, 30 minutes after the onset of symptoms, the positive neurological findings were delirious state of consciousness, miotic pupils with sluggish reaction to light, mild hemiparesis on the left site and slight nucnal rigidity. He lapsed into coma after two hours, however he gradually relieved from these symptoms since the forth hospital day. Cerebrospinal fluid was bloody. Radiograms of the skull revealed decalcification of posterior clinoid process and postero-inferior displacement of pineal calcification. Brain scanning and vertebral angiography demonstrated tumor stain in the posterior portion of the 3rd ventricle. Dimer-X ventriculography revealed the obstruction of posterior portion of the 3rd ventricle and the leakage of Dimer-X through the floor of the 3rd ventricle into the intrasellar subarchnoid space. The patient died after about one year from the onset of symptoms. Any signs of increased intracranial pressure had not been noticed since the forth hospital day; At autopsy we confirmed the posterior portion of the 3rd ventricle was obstructed by tumor. In the floor of the 3rd ventricle there was a round opening which was patient and measured about 3 mm in diameter. Microscopic examination of the tumor showed an oligodendroglioma. Neoplastic cells partially infiltrated into the surface facing to the 3rd ventricle and slight gliosis was observed around the site of rupture. The surface along the subarachnoid space was lined with pia-aracnoid membrane except at the site of rupture. In the past literatures only 6 cases of spontaneous 3rd ventriculostomy have been reported. Three cases were observed spontaneous arrest of obstructive hydrocephalus. Our case is the first reported case of spontaneous 3rd ventriculostomy through the floor of the 3rd ventriculostomy through the floor of the 3rd ventricle. We suggested the pathogenesis of spontaneous 3rd ventriculostomy is a result of destruction at normally weak points of 3rd ventricle (ex. anterior, posterior wall and floor of 3rd ventricle), which has the reultant internal hydrocephalus caused by recurrent obstruction of C.S.F. pathway or long-standing obstructive hydrocephalus.

Adult↗
PubMed1976

[Paratrigeminal epidermoid originated in the meckel's cave (author's transl)].

We have reported a case of paratrigeminal epidermoid originated in the Meckel's cave. A 30 years old man was admitted to the department of neurosurgery with chief complaints of continuous right facial pain and numbness of entire right side of the face of three years duration. The positive neurological findings were hypesthesia over the distribution of the right trigeminal nerve, absence of the right corneal reflex and nystagmus on left lateral gaze. Caloric response was absent on the right side, however the audiogram showed normal. Cerebrospinal fluid examination was within normal limit. Electromyography showed giant spike in the right masseter and temporal muscles. Radiogram of the skull revealed a bone-destroying lesion over the medial florr of the right middle fossa involving the apex of the petrous bone (Fig 1). Right carotid angiography showed straightening and forward displacement of C4- C5 portion of the carotid siphon in the lateral view, and vertebral angiography showed displacement of basilar artery to the left side, upward displacement of the right posterior cerebral and superior cerebellar artery in the frontal view (Fig. 2, 3). At the time of operation, an epidermoid was identified in the Meckel's cave and totally removed microsurgically. Small amount of the tumor extending into the posterior fossa was also removed (Fig. 4, 5, 6, 7). Postoperative course was uneventfull except for an episode of headache and high fever of short duration, suggesting the signs of meningial irritation. Two months postoperativelly patient was relived of facial pain and was discharged with sensory impairment of the right trigeminal nerve distribution. Only 11 cases of paratrigeminal epidermoid, including the cases localized in the Meckel's cave have been reported in the past literatures (Table 1). In this paper we have discussed about the symptomatology and clinical data of paratrigeminal epidermoid and compared with those of trigeminal neurinoma, and meningioma originated in the same region. We would like to emphasize that the importance of differentiating the idiopathic trigeminal neuralgia from the paratrigeminal epidermoid, if the initial symptom of this tumor were tic douloureux. The total removal of epidermoid with capsule is essential treatment following the early diagnosis, however the attempt of total removal is sometimes difficult because of the relationship between the origin, size and extension of this kind of tumor to other important brain structures. And if some of the tumor is left behind at the time of operation, cholesterin meningitis is an important complication.

Adult↗