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Biomedical subjects

S Miyazaki

Publications and source records attributed to S Miyazaki.

At least 847 records · Page 47Linked to original sources
PubMed1981

Relationship between lymphocyte proliferation and migration inhibitory factor production in response to autologous tumor extract in cancer patients.

In forty-nine patients with various carcinomas, cell-mediated immune response to 3M KCl extract of autologous tumor was studied with the use of both lymphocyte proliferation (LP) assay and macrophage migration inhibition (MMI) assay simultaneously. There was no correlation between stimulation index in LP assay and migration index in MMI assay in these simultaneous tests. The results of this study indicate dissociation between cell proliferation and migration inhibitory factor production of lymphocytes in response to autologous tumor extract in patients with various carcinomas.

Breast Neoplasms↗
PubMed1981

Formation of gizzard erosion-inducing substance in heated casein-histidine mixture.

Formation of a toxic substance inducing gizzard erosion (GE) was examined by using mainly a casein-histidine mixture as a simple model of fish meal. When a casein-histidine mixture was heated at 135 degrees C for three or five hours or at 160 degrees C for one hour, it induced severe GE. Changes in pH of histidine solution seemed to have little effect on the production of the toxic substance. Addition of a heated mixture of 30 mg of histidine and 150 g of casein (per kg of diet) failed to induce GE. A mixture of 750 mg of histidine and 150 g of casein was enough to produce a maximal toxicity. A heated mixture of histidine and isolated soybean protein, ovalbumin or gluten induced severe GE. A heated mixture of gelatin and histidine had a somewhat milder toxicity. On the other hand, zein and yeast treated in the same way showed only a slight toxicity. Two kinds of pre-treatment of casein before the addition of histidine were proved to be ineffective to inhibit the formation of the toxic substance. The toxicity of heated casein-histamine was rather lower than that of heated casein-histidine. Studies were also made on releasing of the toxic substance from heated casein-histidine into the soluble fraction by acidic hydrolysis and precipitation of this substance at acidic pH.

Animals↗
PubMed1981

Properties of gizzard erosion-inducing substance in fish meal.

Heated whole fish meal, produced from mackerel, was proved to induce gizzard erosion in broiler chicks by feeding for 6 days. The constituents of the water-soluble fraction of fish meal were suspected to be the cause of this lesion. Of them, histidine, histamine and nucleotides were examined. When added to milk casein and heated, histidine appeared to be the most toxic. It seemed, however, that histamine and IMP (inosine 5'-monophosphate) might be less toxic even when treated in the same way a histidine. Feeding of a large amount of histamine alone resulted in giving rise to a much disturbed profile of body weight gain, while a low incidence of gizzard erosion was observed in this case. Both heated fish meal and a heated mixture of casein and histidine were easily reduced in toxicity by acid hydrolysis. The latter was more sensitive to this treatment. On the contrary, papain had an action to diminish the toxicity of heated fish meal at all. Even after treated with papain, the heated casein-histidine mixture was still effective to induce gizzard erosion. These results might have come from different structural changes caused by heating of the two samples.

Amino Acids↗
PubMed1980

Rapid determination of glycine- and taurine-conjugated bile acids in human bile by high-performance liquid chromatography.

With use of an anion-exchange packing, TSK Gel IEX 540 DEAE, for high-performance liquid column chromatography, glycine- and taurine-conjugated bile acids were separated in 10 min and detected with a differential refractometer. Human bile could be analyzed after a simple pretreatment. The purity of the peaks of glycine- and taurine-conjugated bile acids in human bile was confirmed by enzymatic determinations using 3 alpha-hydroxysteroid:NAD oxidoreductase. The molar ratios of the two forms of the conjugates (glycine/taurine ratios) in bile from normal subjects and from patients suffering from various hepatobiliary diseases were measured.

Bile↗
PubMed1980

Behavioral state cycles, background EEGs and prognosis of newborns with perinatal hypoxia.

The classification of the background EEG was performed in 132 fullterm neonates who had suffered perinatal hypoxia by visual inspection of whole polygraphic records of 2--3 h duration, i.e., maximally depressed, markedly depressed, moderately depressed, mildly depressed, minimally depressed, normal and other, according to the distribution of 7 EEG patterns. The quantitative analysis of the polygraphic record was made in 33 of the above and 10 control infants to investigate the effect of perinatal hypoxia on the background EEG and behavioral state cycle and to confirm the validity of the above classification. The calssification of the background EEG was well correlated with the disturbance of sleep cycle, which was also related to the interval after the hypoxic insult. The relation between sleep states and EEG patterns also had a close correlation with the classification and became progressively disrupted with increasing severity of the background EEG. Each grade of the background EEG abnormality had a different prognostic significance accordsing to the time of the recording. The one in the first week offered the best prognostic value.

Cerebral Palsy↗
PubMed1980

The evolution of some EEG features in normal and abnormal infants.

Evolutionary changes of EEG up to one year in 81 infants followed from neonatal periods were studied. Tracé alternant (TA) disappeared at 1-2 months in infants with normal outcome and those with cerebral palsy (CP or mental retardation (MR). In patients with CP & MR or those with CP & MR & epilepsy (EP), the time when TA disappeared was delayed. Presence of TA at or beyond 2 months suggests severe brain damage such as CP & MR, or CP & MR & EP. The spindle appeared within 3 months in normal infants and those with CP, but in some patients with CP & MR, or those with CP & MR & EP, no spindle ever appeared. The delay of its appearance beyond 3 months in considered to be an unfavorable sign. There is a very good correlation between neonatal background EEGs and the time of disappearance of TA and spindle appearance. The abnormal background EEGs after the first month suggested severe damage, and no specificity such as might reflect a certain type of developmental disability was found.

Age Factors↗
PubMed1980

Guillain-Barré syndrome presenting with signs of ophthalmoplegia.

Two cases of Guillain-Barré syndrome (GBS) presenting with signs of ophthalmoplegia were reported. One showed unilateral internal ophthalmoplegia without external ophthalmoplegia, and the other displayed partial external ophthalmoplegia with sluggish pupillary response to light. It is important to keep in mind the possibility of GBS with acute onset of internal and/or external ophthalmoplegias.

Child↗
PubMed1980

The role of perinatal brain injury in the genesis of childhood epilepsy.

In order to elucidate the significance of perinatal brain damage in the etiology of epilepsy, 139 full-term neonates considered to have suffered a severe degree of perinatal hypoxia were examined neurologically and electroencephalographically for two-nine years. Thirty-eight (27.3%) of them developed epileptic seizures during the follow-up period. Sixteen infants developed infantile spasms at ages two-13 months, while 10 manifested generalized motor seizures mainly at one-four years. They all had neonatal background EEGs suggesting a severe degree of brain damage, although the infants with infantile spasms and myoclonic seizures showed more abnormal neonatal EEGs than those with other types of fits. The combination of multiple factors, mainly exogenous and constitutional, is necessary for the development of epileptic seizures, especially in patients with a lesser degree of brain damage.

Birth Injuries↗