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Biomedical subjects

S Miyake

Publications and source records attributed to S Miyake.

At least 343 records · Page 19Linked to original sources
PubMed1982

Clinical evaluation of left ventricular performance in patients with myocardial infarction: comparison of hemodynamic responses to exercise and angiographic findings.

In order to evaluate the left ventricular performance during exercise in patients with myocardial infarction, we performed a symptom-limited multistage exercise test using a bicycle ergometer in the supine position on 82 patients with myocardial infarction, and their hemodynamic responses to exercise were analyzed. Patients were subdivided into three groups according to the levels of pulmonary capillary wedge pressure (PCWP) and cardiac index (CI) obtained at the end-point of the exercise: Group I (20 patients) with PCWP less than 18 mmHg and CI greater than or equal to 5.0 L/min/m2; Group II (32 patients) with PCWP greater than or equal to 18 mmHg and CI greater than or equal to 5.0 L/min/m2; Group III (30 patients) with PCWP greater than or equal to 18 mmHg and CI less than 5.0 L/min/m2. Exercise tolerance expressed as the duration of exercise was 11.9 +/- 0.5 (SEM) min in Group I, 10.6 +/- 0.4 in Group II and 7.8 +/- 0.5 in Group III, which was closely correlated with the left ventricular function observed at the end-point of the exercise. During exercise stroke volume index (SVI) decreased slightly in Group III, while it increased significantly in Groups I and II. The extent of coronary artery lesion in Group III was more severe than in Groups I and II. In 50 patients without prior myocardial infarction, infarct size estimated by total released CPK was larger in Group III than in Group I. These findings indicate that coronary artery lesion and infarct size are important factors contributing to left ventricular performance during exercise in patients with myocardial infarction.

Adult↗
PubMed1982

Increased double marker lymphocytes in systemic lupus erythematosus and lymphoproliferative disorders.

In this study we were able to confirm the presence of double marker lymphocytes (D cells) in human peripheral blood from normal subjects in addition to patients with SLE and malignant lymphoma. Quantitation of D cells and Null lymphocytes (N cells) in peripheral blood was not feasible via conventional rosette methods. The present combination method, using two indicators, neuraminidase treated sheep red blood cells (nSRBC) and Immunobeads, allows for simultaneous demonstration of T, B, N and D lymphocytes in a simple reproducible manner. The mean percentage of the D cell counts with this method was 1.8% of total lymphocytes from normal donors, 7.0% in patients with SLE, and 29.2% in patients with malignant lymphoma. The simultaneous quantitation of T, B and N cells in these blood samples was compared to the results of conventional methods, i.e. E rosettes for T cells and EAC rosettes for B cells, which gave similar results. This combination method for simultaneous enumeration of human peripheral lymphocyte subpopulations may offer significant advances in the study and diagnosis of various clinical entities.

Adolescent↗
PubMed1982

Auto-oxidative damage in Behçet's disease--endothelial cell damage following the elevated oxygen radicals generated by stimulated neutrophils.

The functions of phagocytes are enhanced in patients with Behçet's disease, therefore, we investigated the neutrophil-derived oxygen intermediates (OI) and lysosomal enzymes from 17 patients receiving glucocorticosteroids (steroids) and colchicine. Cultured endothelial cells were incubated with neutrophils to assess tissue injury. In cases of the complete type, in the active stage of the disease, OI production was markedly increased. The other patients showed significantly higher OI and higher lysosomal enzyme levels than patients with other diseases (controls) receiving drug therapy. Cytotoxicity tests showed that the 51Cr release was also significantly higher. The destruction of desmosomes and cell deformation were demonstrated electron microscopically. The simultaneous addition of superoxide dismutase and catalase in the cell culture decreased the 51Cr release to control levels. These findings suggest that neutrophils from patients with Behçet's disease generate high levels of OI, resulting in endothelial tissue damage.

Adolescent↗
PubMed1981

Aniseikonia in patients with a unilateral artificial lens, measured with Aulhorn's phase difference haploscope.

Aniseikonia was measured in unilaterally pseudophakic patients using Aulhorn's phase difference haploscope. Mean values of aniseikonia were 1.5% horizontally and 2.0% vertically without correction, and 2.1% horizontally and 2.3% vertically with correction. With spectacle correction, the greater the dioptric difference between two eyes, the greater the amount of aniseikonia. In either case, patients tolerated these amounts of aniseikonia according to our criteria of aniseikonia tolerance.

Aged↗
PubMed1981

Clinical significance of exercise-induced ST changes in patients with prior myocardial infarction: comparison of electrocardiographic and angiographic findings.

In order to investigate the clinical significance of exercise-induced ST changes in patients with prior myocardial infarction, we performed an exercise tolerance test using bicycle ergometer, coronary arteriography and left ventriculography in 77 patients with prior myocardial infarction and compared exercise-induced ST changes with coronary arteriographic and left ventriculographic findings. At end-point time in the exercise test, we observed abnormal ST elevation in 36 patients (46.7%), ST depression in 11 (14.3%) and no significant ST changes in the remaining 30 (39.0%). After exercise, 29 out of 48 patients (60.4%) with prior anterior myocardial infarction had significant ST elevation, 9 (18.8%) had ST depression, and 10 patients (20.8%) had no significant ST changes. Of the 29 patients with exercise-induced ST elevation, 26 (89.6%) had no significant coronary lesion or simply had single vessel disease, and 6 of 9 patients with ST depression (66.7%) had multiple vessel disease. Furthermore, 18 of 29 patients with exercise-induced ST elevation (62.1%) had dyskinesis, 8 (27.6%) had akinesis and only 3 (10.3%) had hypokinesis. ON the other hand, only 2 of 9 patients with exercise-induced ST depression (22.2%) had dyskinesis, 5 had akinesis, and 2 had hypokinesis. Only 7 out of 29 patients (24.1%) with prior inferior myocardial infarction had ST elevation, 2 (6.9%) had ST depression, and no significant ST changes were observed in the remaining 20 (69.0%). No significant correlation was obtained between exercise-induced ST changes and coronary arteriographic and left ventriculographic findings. These findings strongly suggest that exercise-induced ST elevation is commonly observed in patients with anterior myocardial infarction and correlated with the severity of abnormal left ventricular wall movement, and ST depression is related with the extent of coronary artery lesion.

Adult↗
PubMed1981

Effect of calcium antagonists on the electrical alternans of the ST segment during acute coronary occlusion in dogs.

Effects of antagonists on the ST alternans during acute coronary occlusion were examined in dogs. The intravenous administration of verapamil at doses of 0.1 mg/Kg and 0.2 mg/Kg prominently attenuated the degree of alternans. Diltiazem at dose of 0.2 mg/Kg also attenuated the degree of alternans. Dipyridamole at dose of 0.5 mg/Kg did not significantly attenuate the degree of alternans. Verapamil significantly inhibited the ST-segment elevation. After verapamil, ST alternans did not occur even after a longer period of occlusion when changes in QRS complex and the ST-segment elevation were remarkable. It is possible that verapamil inhibits ST alternans by both the protecting effect against ischemic injury and a direct effect on the electrical activity of the myocardial cell membrane.

Acute Disease↗
PubMed1981

The therapeutic use of games with mentally retarded adults.

This article provides conceptualizations of play as a learning and survival behavior and presents findings of a study of the use of games with mentally retarded adults. In this study the aim was to describe both how therapists can use games as therapeutic media and how changes can be observed in the subjects. Along with increases in play, improvement in motor behavior, cognitive abilities, affect, attention, self-confidence, and social interaction was observed.

Adult↗