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Biomedical subjects

S Miyahara

Publications and source records attributed to S Miyahara.

At least 73 records · Page 4Linked to original sources
PubMed1987

[A case of malignant peritoneal mesothelioma with a good response to treatment].

A rare case of malignant peritoneal mesothelioma in a 49-year-old Japanese woman is presented. The tumor was limited to the peritoneum, and was cytologically and histologically identified as being composed of two components, epithelial and non-epithelial forms. The transition in her CA-125 level suggested that this tumor had good prospects of developing into a malignant mesothelioma. The good prognosis of the patient is considered to be attributed to detecting this tumor in its early stage and to aggressive chemotherapy.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1987

[Clinical studies on flomoxef in respiratory infection].

Clinical efficacy, bacteriological effect and safety of a new antibiotic flomoxef (FMOX, 6315-S) in respiratory infections were studied. Efficacy of FMOX in 6 patients with infectious diseases including 2 cases with pneumonia, 3 cases with acute exacerbation by respiratory infection, 1 case with obstructive pneumonia were clinically evaluated. Two strains of Haemophilus influenzae, 1 strain of Streptococcus pneumoniae and 1 strain of Staphylococcus aureus which were detected as causative organisms in 2 cases disappeared or decreased after treatment with FMOX. Assessing both clinical and bacteriological findings, effects of FMOX were good in 5 cases and fair in 1 case. No adverse effects were observed in clinical or laboratory findings. Consequently, FMOX is considered to be a very useful antibiotic in the treatment for respiratory infectious diseases.

Adult↗
PubMed1985

[Current significance of stereotactic exploration in the diagnosis and therapy of space-occupying cerebral processes].

To reach good functional results in patients with spaceoccupying processes--especially with those localized in the dominant hemisphere operative treatment should be planned individually, which is impossible if all diagnostic assessments are followed by the same surgical procedure. The choice of appropriate method of therapy in case of brain tumor depends on various factors, such as the histological nature, extent and volume, relationship to the brain structures and vessels, and spatial form of the growth. The synthesis of all neuroradiological information from stereotactic exploration, together with the histological findings from stereotactic serial biopsies yields a three-dimensional representation of the brain with the tumor. This method seems to offer the optimal basis for the choice of appropriate treatment--especially for gliomas--between surgery, radiotherapy (external or/and interstitial), endocavitary radiation therapy or drainage.

Adolescent↗
PubMed1984

A case report of pancreatic metastasis of an intracranial angioblastic meningioma (hemangiopericytoma) and a review of metastatic tumor to the pancreas.

The authors report a case of solitary metastasis to the pancreas from an intracranial angioblastic meningioma (hemangiopericytoma) and discuss secondary (metastatic) tumors of the pancreas. A 65-year-old man developed a pancreatic tumor 15 years after the craniotomy was performed for a parasagittal meningioma. Histological investigation of the pancreatic tumor excised as a biopsy on exploratory laparotomy revealed a tumor identical to the intracranial meningioma. It was concluded that the intracranial angioblastic meningioma had recurred and metastasized to the pancreas.

Aged↗
PubMed1984

Mercury dispersion from Minamata Bay to the Yatsushiro Sea during 1975-1980.

Nearly three decades have passed since the first outbreak of Minamata disease (methyl mercury poisoning). Since then, the Japanese government has taken the position that mercury contamination is occurring only within Minamata Bay, and commercial and sport fishing has been prohibited only within the bay. However, about 30 tons of mercury has quietly been moving into the Yatsushiro Sea, although most of the mercury (150 tons) which was released (and which induced the disease) has been deposited with bed sediments within Minamata Bay. Observations from 1975 to 1980 confirm that the dispersion of the mercury from the bay into Yatsushiro Sea is imminent and that the average concentration of mercury in bed sediments has increased 315% between 1975 and 1980 in the Yatsushiro Sea.

Chemical Precipitation↗
PubMed1984

[Liver regeneration and the immune system. II. Suppressor activities of lymphocytes activated in vivo by liver regeneration and their genetic control].

The lymph node cells (LNC) activated in vivo by liver regeneration following partial hepatectomy of mice (pLNC: primed lymph node cells) respond to regenerating liver cells in vitro with typical secondary immune response characteristics (as shown in Paper I). These lymph node cells activated in vivo suppress the proliferation of responder lymphocytes cultured with mitomycin C (MMC)-treated regenerating syngeneic liver cells (sMLHLR). The suppressive activity was already present in LNC 4 days after partial hepatectomy and remained unchanged for at least 16 days. These pLNC were effective not only on sMLHLR but also on syngeneic mixed lymphocyte culture (sMLR) and allogeneic mixed lymphocyte culture (MLR), of which responder cells share I-A (I-B) subregions of MHC with pLNC. The pLNC restimulated in vitro with regenerating liver cells (ppLNC: in vitro reactivated pLNC) suppress the proliferation of syngeneic responder cells in sMLR, but not of cells from congeneic mice differing from the ppLNC at a cluster of genes linked to the Ig locus. Thus the suppressive activity of pLNC is controlled by the I-A (I-B) subregions of the MHC and that of ppLNC by genes in the Ig region.

Animals↗
PubMed1984

[Liver regeneration and the immune system. 1. In vitro and in vivo activation of lymphocytes by liver regeneration].

When syngeneic lymphocytes and mitomycin C (MMC) treated regenerating liver cells prepared from a partial hepatectomized mice are cultured together, the in vitro DNA synthetic response is activated (sMLHLR: syngeneic mixed hepatectomized liver cell-lymphocyte culture). Ia+ Kupffer cells play an important role as stimulators in the responses, since the stimulating activity of regenerating liver cells is lost by the pretreatment of them with anti-Ia monoclonal antibody plus complement or the removing Kupffer cells from them. The lymphocytes are activated also in vivo during liver regeneration after a partial hepatectomy. Because, when lymphocytes prepared from hepatectomized mice are cultured with regenerating liver cells, lymphocytes are stimulated to accelerate their DNA synthesis in a typical manner of the secondary immune responses (secondary sMLHLR). In primary sMLHLR, the responder cells are mainly Lyt-1+ whereas in secondary sMLHLR they are mainly Lyt-2+. The mechanism of changing the Lyt phenotype of major responder cells from Lyt-1 to Lyt-2 during sMLHLR is discussed.

Animals↗
PubMed1983

Regeneration and the immune system. I. In vitro and in vivo activation of lymphocytes by liver regeneration and the role of Kupffer cells in stimulation.

When syngeneic lymphocytes and mitomycin C-treated regenerating liver cells, prepared from partially hepatectomized mice, are cultured together, the in vitro DNA synthesis is activated (sMLHLR: syngeneic mixed hepatectomized-liver cell-lymphocyte culture). The Ia+ Kupffer cells play an important role as stimulators in the response, since the stimulating activity of regenerating liver cells is lost either by the pretreatment with anti-Ia monoclonal antibody plus complement or by the removing Kupffer cells from them. The lymphocytes are also activated in vivo during liver regeneration following partial hepatectomy. When lymphocytes, prepared from hepatectomized mice, are cultured with regenerating liver cells, the lymphocytes are stimulated to accelerate their DNA synthesis in a manner typical of the secondary immune responses (secondary sMLHLR). In primary sMLHLR, the responder cells are mainly Lyt-1+, whereas, in secondary sMLHLR, they are mainly Lyt-2+. The mechanism of changing the Lyt phenotype of major responder cells from Lyt-1 to Lyt-2 during sMLHLR is discussed.

Animals↗
PubMed1983

Regeneration and the immune system. II. Suppressor activities of lymphocytes activated in vivo by liver regeneration and their genetic control.

The lymph node cells (LNC) activated in vivo by liver regeneration following partial hepatectomy of mice (primed lymph node cells) respond to regenerating liver cells in vitro with typical secondary immune response characteristics (Miyahara, S. et al., Eur. J. Immunol. 1983. 13: 878). These LNC activated in vivo suppress the proliferation of responder lymphocytes cultured with mitomycin C-treated regenerating syngeneic liver cells (sMLHLR). The suppressive activity was already present in LNC 4 days after partial hepatectomy and remained unchanged for at least 16 days. These primed LNC were effective not only on sMLHLR but also on syngeneic mixed lymphocyte culture (sMLR) and allogeneic mixed lymphocyte culture, of which responder cells share the I-A (I-B) subregions of the major histocompatibility complex (MHC) with primed LNC. At least one cell in the suppressor circuit is a T cell. The primed LNC restimulates in vitro with regenerating liver cells (in vitro reactivated primed LNC) suppressed the proliferation of syngeneic responder cells in sMLR, but not of cells from congeneic mice differing from the in vitro reactivated primed LNC at a cluster of genes linked to the Ig locus. Thus the suppressive activity of primed LNC is controlled by the I-A (I-B) subregions of the MHC and that of in vitro reactivated primed LNC by genes in the Ig region. The role of these suppressive cells in liver regeneration is discussed.

Animals↗
PubMed1982

Inhibitory action of the ventral noradrenergic bundle on the lateral hypothalamic neurons through alpha-noradrenergic mechanisms in the rat.

Electrical stimulation of the ventral noradrenergic bundle (V-NA bundle) produced 3 types of responses in lateral hypothalamic neurons: IPSPs, a polysynaptic EPSP-IPSP sequence and antidromic spikes. The IPSPs were considered to be monosynaptic due to the fixed latencies seen at stimulus intensities. Iontophoretic application of an alpha-NA antagonist blocked only the presumed monosynaptic inhibition. Most of the glucose-sensitive neurons were inhibited by stimulation of the V-NA bundle. These results may account for the hyperphagia and obesity produced by selective lesions of the V-NA bundle.

Animals↗