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Biomedical subjects

S Mehta

Publications and source records attributed to S Mehta.

At least 325 records · Page 18Linked to original sources

Pain quantum and wound healing: a comparison of interrupted inversion PDS and standard nylon sutures in abdominal skin closure.

Patients' postoperative pain experience during 5 days after hernia repairs or upper abdominal procedures was compared when skin closure was achieved by either full thickness interrupted sutures or subcuticular interrupted inversion sutures. Quantitative pain assessments were made using linear analogue charts and standardised analgesic requirements. Clinical advantage for the subcuticular technique was confirmed for the hernia group and possible advantage in the upper abdominal closure, suggested by lesser analgesic requirement. Statistical analysis has lent support to the hernia group findings but is less clear in the upper abdominal group. A comparison of wound healing, sepsis and cosmetic outcome showed no apparent advantage to either method. Economies and patient preference favoured the subcuticular method.

Abdominal Muscles↗

Disposition of sulphadiazine in young rhesus monkeys with protein calorie malnutrition.

Disposition of sulphadiazine was assessed in young rhesus monkeys under three stages of nutritional manipulations i.e. control, protein calorie malnutrition (PCM) state and following nutritional rehabilitation. There was no alteration in the absorption kinetics except a delayed peak in the malnourished group. A decrease in volume of distribution of drug in the peripheral compartment was noted. The most significant changes observed was in the elimination kinetic parameter. The (Ke) elimination rate constant and the clearance rate showed a significant decrease which could be either because of decreased rate of acetylation or a decrease volume of distribution.

Animals↗

Duodenal varices.

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Duodenum↗

Characterization of receptors for a T cell derived cytosolic BCGF-60kD.

A 60 kD cytosolic protein derived from human peripheral blood T cells has been shown to mediate proliferation in BCGF responsive long term B cell cultures. In this report, we show cBCGF-60kD can be radioiodinated with no significant loss of biologic activity and bound specifically to B cell surface membrane receptors. The time course of 125I-cBCGF-60kD demonstrated that binding reached saturation within 40 minutes, (T 1/2 of 15 minutes). Scatchard analyses of ligand-receptor binding identified a high affinity receptor (0.6(-3) x 10(3) receptors per cell) having a dissociation constant of 1-8 pM. Partial cross-competition experiments with a secreted, T cell derived BCGF-12kD identified a potential receptor heterogeneity on BCGF responsive B cell line.

B-Lymphocytes↗

Molecular cloning and expression of a human B-cell growth factor gene in Escherichia coli.

A human B-cell growth factor (BCGF) (12 kilodaltons) supports the clonal proliferation of B lymphocytes. A clone was isolated that contained the proper structural sequence to encode biologically active, 12-kilodalton BCGF in Escherichia coli and to hybridize to a specific messenger RNA, identified by in vitro translation in Xenopus laevis oocytes. A relatively hydrophobic region of 18 amino acids was found at the amino terminal of the 124-amino acid-long polypeptide. The carboxyl terminal is composed of at least 32 amino acids that are derived from nucleotide sequences bearing significant homology to the Alu repeat family.

Amino Acid Sequence↗

Tuberculous peritonitis in children.

Five cases of tuberculous peritonitis are presented with clinical and radiological features. The diagnosis was based on clinical and radiological findings. Peritoneoscopy and laparatomy was not performed in any of the cases. All the patients responded well to the anti-tubercular therapy.

Child↗