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Biomedical subjects

S Marghescu

Publications and source records attributed to S Marghescu.

At least 37 records · Page 2Linked to original sources
PubMed1984

[Congenital reticular ichthyosiform erythroderma].

A 57-year-old female patient has had generalized cutaneous lesions since birth. Clinically there are patch- and band-like areas of erythrokeratotic and pigmented skin in reticular arrangement. The most important histological findings are band-like parakeratosis, psoriasiform acanthosis, vacuolization of the keratinocytes in the upper layers of the epidermis with a high frequency of binuclear cells, and deposits of amyloid in the dermis. Ultrastructurally, the formation of perinuclear shells built from a three-dimensional network of fine filaments is the most peculiar finding. Binuclear cells are frequently found from the first suprabasal layers. Oedematization of the perinuclear cytoplasm within the shells finally leads to vacuolization of the uppermost granular cells. The horny layer is parakeratotic and contains debris of nuclei and lipid vacuoles. In the clinically normal appearing skin within the reticular network, keratinization occurs in a completely normal fashion. In spite of a good response to retinoid treatment, perinuclear shells and binuclear cells remain demonstrable in involved regions. The clinical, histological and ultrastructural peculiarities of this case suggest the diagnosis of a special type of congenital disturbances of keratinization, which can be clearly distinguished from the well-known ichthyosiform dermatoses and other inborn errors of keratinization.

Biopsy↗
PubMed1983

[External corticoid therapy: continuous versus discontinuous use].

Taking into account the factors of local bioavailability, the phenomenon of tachyphylaxis and biorhythm as well as the skin and the internal production of cortisone, side effects can be reduced by the intermittent use of topical corticoid preparations and reduced dosage. Atopic dermatitis is taken as an example to explain some corticoid-saving measures during long-term treatment.

Administration, Topical↗
PubMed1982

[Psoriasis therapy with retinoid].

Retinoids are effective in all forms of psoriasis and can be used alone or in combination with other therapeutic measures (anthralin, corticoids, PUVA, SUP). The effect of retinoids on psoriasis, in the final analysis still open to question, is discussed with regard to three parameters of psoriatic epidermis (enhanced proliferation, disturbance in differentiation, leucotaxis).

Anthralin↗
PubMed1981

Immunological features of psoriasis. Effects of Ro-109359, concanavalin A, pokeweed mitogen, and methotrexate on cultivated lymphocytes.

Isolated peripheral mononuclear cells of psoriasis patients with different disease characteristics, e. g. head-localised, quiescent guttata, confluent active widespread and erythrodermic, were cultured in a modified Mishell-Dutton system. Using the plaque-forming cell (PFC) assay, single cell antibody formation was studied, and class distribution monitored, adding pokeweed mitogen (PWM), concanavalin A (ConA), methotrexate (MTX) or Ro-109359/31, as well as autologous sera to the culture. PFC-estimation vs. sheep red blood cells (SRBC) and burro red blood cells (BRBC) revealed a distinct suppression of primarily IgG-PFC in some of the PWM-treated patients' cultures; ConA maximally reduced PFC by only 50%, compared to 100% for normal immune cells. Ro-109359/31 reduced mainly IgG-PFC in the co-cultures with PWM or autologous sera. MTX resulted in a reduction of IgG-PFC and IgM-PFC equally. The results were compared with cultured immune cells from normal individuals. The two antigenically different indicators, the partial abolition of ConA induced suppression, broad-based immunoglobulin elevation in the sera, and the mainly IgG-formation hint at the role of polyclonal B-cell activation in the perpetuation of psoriasis, which can be specifically reduced by Ro-109359/31. Suppressor cell dysfunctions remain to be discussed.

Antibody Formation↗
PubMed1980

[Disorders of immune regulation in psoriasis].

Immune abnormalities in psoriasis vulgaris are described. Anti-stratum corneum antibodies deposited with C3 have been found in patients with psoriasis. A lot of other immune abnormalities identified in psoriasis: increased serum IgG and IgA levels, lowered DNCB-sensitization, alteration in polymorphnuclear leukocytes (PMN) function, decreased number of T cells, lack of response to concanavalin A (ConA) and an increase in the polyclonal B cell activation. the authors believe that the immunoregulatory defect is due to the disorder of the skin.

Autoantibodies↗
PubMed1980

[Autoallergic drug exanthemas].

A short discussion of known facts on iatrogenic autoallergic dermatoses of the pemphigus and lupus erythematosus type followed by the clinical, histological and immunological data of a subepidermal autoallergic bullous dermatosis in two children after anticonvulsive treatment with primidon.

Autoimmune Diseases↗
PubMed1980

[Pseudolymphoma].

Explore the source record for details and available documents.

Age Factors↗