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Biomedical subjects

S Marghescu

Publications and source records attributed to S Marghescu.

At least 19 recordsLinked to original sources
PubMed1992

Localization of fibronectin in the initial lymphatics and blood vessels of normal human skin: an immunoelectron microscopic investigation.

The initial lymphatics of the human skin do not possess a basal lamina, but a subendothelial fibrous network, of which we do not know the biochemical and immunohistological composition. We investigated the wall of blood vessels and initial lymphatics in normal human skin for the presence of fibronectin by immunoelectron microscopy. We found discontinuous linear subendothelial diaminobenzidine (DAB) reaction products in both blood vessels and lymphatics. In addition fibronectin could be found at the anchoring fibrils of the initial lymphatics.

Adult↗
PubMed1989

[Skin metastases of internal cancers. A critical review of the literature].

The value of global statistical data on skin metastases of internal carcinomas is a relative one, since skin metastases are frequently seen in carcinomas of the breast, but rarely found in other internal cancer. Nevertheless, the study of skin metastases is important, because they may help to identify and locate an occult carcinoma; moreover they can serve as a parameter to appreciate the efficiency of polychemotherapy.

Breast Neoplasms↗
PubMed1989

[Congenital poikiloderma].

Poikiloderma is characterized by the syntopy of diffuse atrophy, leukomelanodermia and teleangiectasia. We differentiate between symptomatic, idiopathic and congenital forms. Congenital poikiloderma shows 3 decisive features: early appearance, familial occurrence, and various associated congenital malfomations. On account of distinctive features - such as the consanguinity of the parents, cataracts, leukoplakia, bullas, and verrucous keratoses - we can distinguish between 5 biotypes of congenital poikiloderma, which are named after their first observers: Rothmund's, Thomson's, Zinsser's, Brain's and Dowling's syndrome.

Diagnosis, Differential↗
PubMed1988

[Lupoid form of rosacea-like dermatitis].

In a 9-year-old girl, a lupoid variant of rosacea-like dermatitis was observed following the topical application of potent glucocorticosteroids. In addition to the micro- and macro-papulopustular forms, this is a third clinical variant of the disease, which has to date only been described in children.

Administration, Topical↗
PubMed1987

Disseminated bilateral hyperkeratotic variant of porokeratosis Mibelli.

Clinical, histopathological, and ultrastructural features of a new clinical variant of porokeratosis Mibelli (PM) are presented. We report a solitary case of a patient, male aged 62, who developed disseminated verrucous nodules on the buttocks and the lower extremities 3 years before diagnosis. Histopathologically, all specific signs of the keratinization disorder of PM were demonstrable; in addition, however, multiple cornoid lamellae were found at the margin as well as in the center of the lesions, which only in part showed relationships to the epidermal appendages. In the papillary dermis, numerous ectatic capillaries were conspicuous. Using electron microscopy the same specific abnormalities of the keratinization process as known from classical cases of PM could be demonstrated: autophagocytic cells that revealed perinuclear edematization and vacuolization, accumulation of autophagic vacuoles and heterolysosomes, and dyskeratotic corps ronds-like cells that become transformed to fibrillar or Civatte bodies. Problems of the classification, differential diagnosis, and pathomorphogenesis are discussed.

Age Factors↗
PubMed1986

[Eczematids].

Eczematids are itching dermatoses showing indistinct redness, pityriasiform scales, and superficial fissures of the horny layer. The seborrheic and sebostatic variants differ with regard to localization of the dermatosis and condition of the skin surface. Their relationship to the imbalance of production and consumption of skin surface lipids is discussed.

Dermatitis, Seborrheic↗
PubMed1985

[Local treatment of psoriasis with glucocorticosteroids].

With regard to indications for topical treatment of psoriasis with glucocorticosteroids, the resorptive toxicity and topical side effects of the drug are decisive. Equivalent therapeutical agents, such as dithranol, UV light and retinoids, limit their supplementary use in the management of this disease.

Administration, Topical↗
PubMed1979

[Yellow-nail syndrome from d-penicillamine].

The yellow nail syndrom consists of the triad of scleronychia (yellow nails), lymphedema and respiratory tract involvement. The nail changes include symmetrical involvement of finger and toe nails with regression of the nail sheath, paling of the half-moon, arrest of longitudinal growth, thickening, yellow coloration, increased transverse convexity, ridging and partial separation of the nail. This report describes a case of drug-induced yellow nail syndrom due to penicillamin.

Adult↗
PubMed1976

[Allergic delayed reactions of the skin: the role of the antigen histotopy].

Delayed skin reaction to tuberculin were elicited in 10 healthy persons by patch testing and intracutaneous application of the antigen (Tine-Test). Biopsies revealed basically identical tissue reactions. After intracutaneous injection of the antigen as well as after Tine-testing the changes were solely found in the dermis, while after patch testing dermal and epidermal alterations were prominent. The type of response elicited by the same allergen in man-the so called tuberculin type of the eczematous type-therefore are due to a differential localization of the antigen.

Eczema↗