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Biomedical subjects

S M Hunter

Publications and source records attributed to S M Hunter.

At least 37 records · Page 2Linked to original sources
PubMed1989

Risk factors in early life as predictors of adult heart disease: the Bogalusa Heart Study.

The adult heart diseases, coronary artery disease and essential hypertension, are now clearly recognized to begin in childhood. The evidence comes from autopsy studies of cardiovascular-renal changes in the first two decades of life. Cardiovascular risk factors can be identified in children just as in adults and these have a high correlation with the anatomic disease. This relationship underscores the importance of risk factor screening of children. Of interest is that clinical risk factors tend to persist within a rank (track) so that studies in childhood can be predictive of future levels. Behavior and lifestyle of eating, cigarette smoking, alcohol intake, and use of oral contraceptive pills influence risk factors in children. Familial aggregation of risk factors are also noted. Studies of apolipoproteins, B and A-I, have identified subsets of children that have a greater frequency of paternal myocardial infarction. The findings from the Bogalusa Heart Study and other epidemiological studies of children show the need to begin prevention of adult heart disease in early life. Approaches to prevention should include high risk families and children and a public health or population approach. Cardiovascular health education for elementary school children should be directed to children in the general population in an effort to encourage them to adopt healthy life styles.

Aging↗
PubMed1988

The interaction of alcohol and tobacco use in adolescents and young adults: Bogalusa Heart Study.

Alcohol and tobacco usage patterns were assessed in 1,811 children and young adults, 12-24 years of age. The prevalence of cigarette smoking and alcohol consumption increased with age in all race and sex groups. Smokeless tobacco use (chewing tobacco and snuff) was primarily seen in white males with the highest prevalence rates in 12-15 year olds. Among white males who reported smokeless tobacco usage, 44% of the 12-17 year olds and 80% of the 18-24 year olds reported concurrent alcohol use. There was a significant interaction between alcohol consumption and cigarette smoking in all four race-sex groups (p less than 0.001). Given the potential synergistic relationship between ethanol and tobacco products on oral and upper gastrointestinal tract cancer, as well as between smoking and cardiovascular disease, the long term effects from these behaviors could be troublesome. Since healthy lifestyles are established in youth, early intervention on alcohol and tobacco use is needed to prevent the future morbidity and mortality from cancer and cardiovascular disease.

Adolescent↗
PubMed1988

Heart Smart: a school health program meeting the 1990 Objectives for the Nation.

The importance of health promotion is recognized throughout the nation. The Surgeon General's report of 1980, Promoting Health/Preventing Disease, delineates objectives for intervention in 15 health priority areas. Approximately one-third of the objectives relate directly to the health of children, and many are addressed by a comprehensive cardiovascular (CV) health promotion program for elementary school children--Heart Smart. Priority areas addressed by this program are high blood pressure control, nutrition, fluoridation and dental health, smoking, misuse of alcohol and drugs, physical fitness and exercise, and control of stress and violence. Heart Smart is a cognitive behavioral intervention designed to address health enabling and reinforcing factors within the school environment. It is based on data from the Bogalusa Heart Study which clearly document the need for CV health intervention beginning early in life. Heart Smart includes a longitudinal classroom curriculum, an aerobic fitness program taught within physical education classes, a school lunch program offering CV healthy foods, and a teacher staff development program. The goal is to reduce CV risk factors in children. With health-enhancing behavior change of the students, family, and elementary school staff, objectives for CV risk reduction in our nation can be achieved.

Adolescent↗
PubMed1987

Quantification of proteins in the low nanogram range by staining with the colloidal gold stain AuroDye.

A simple assay for proteins in the low nanogram range is described. Proteins are bound to nitrocellulose paper in a band, stained with the commercially available colloidal gold stain AuroDye (a registered trademark of Jansen Life Sciences Products), and quantified by scanning densitometry: 1.25 to 20 ng of protein can be consistently measured. Variation in the staining intensity of different proteins is discussed. DNA, RNA, polyvinylpyrrolidone, Ficoll, and 6 M urea do not affect the assays, and samples from cellular material in a simple lysis buffer containing 0.1% of sodium dodecyl sulfate can be assayed.

Animals↗
PubMed1987

Characterization of a comprehensive type A measure for children in a biracial community: the Bogalusa Heart Study.

To evaluate the development of Type A-like behavior in children, responses to the Hunter-Wolf Instrument were studied in 2128 children in Bogalusa, Louisiana, a biracial community. Test-retest reliability measures were generated by retesting a random subsample of 387 children 2 weeks after the initial testing. Norms were tabulated for each of the age, race, and sex groups. Increases in total and subscale scores with age were noted except for the Hostility subscale, which decreased dramatically in the older groups. White males had higher average scores during the entire period than other groups and scored significantly higher than other groups on subscales, created from principal-components analysis, measuring Eagerness and Hostility. Low test-retest correlations were observed in children younger than 13 years of age. Of the four race-sex groups studied, white males appear to accrue the highest risk for coronary heart disease from type A-like behavior.

Adolescent↗
PubMed1987

Comparison of the prevalence of type A behavior in boys and girls from two contrasting socioeconomic status groups.

The prevalence of Type A behavior in children from lower-class rural and upper-class urban backgrounds was compared using the Hunter-Wolf A-B Self-Rating Scale (H-W A-B). Analyses of variance were performed for two levels of socioeconomic status (SES), two levels of race (black and white), two levels of gender, and two levels of age (9-11 and 13-14). A significant difference for SES was found in the predicted direction with a greater prevalence of Type A being found among upper-urban children (p less than .001). There was also a significant effect for race (p less than .0001). Although there was a significant effect for gender with boys scoring higher (p less than .001), there was no difference between boys and girls within either SES group, and both boys and girls in the upper-urban group were more Type A than boys and girls in the lower-rural group (p less than .001). The possibility that the lack of sex differences within groups may reflect changing lifestyles for young women is discussed as a topic worthy of further epidemiological investigation.

Adolescent↗
PubMed1987

Adverse influences of alcohol, tobacco, and oral contraceptive use on cardiovascular risk factors during transition to adulthood.

Risk factors for cardiovascular disease were measured in 990 young adults, aged 17-24 years, in a 1982-1983 survey of the biracial (black-white) community of Bogalusa, Louisiana. Even after controlling for age and obesity, several lifestyle factors (cigarette smoking, alcohol consumption, and oral contraceptive use) were independently related (p less than 0.05) to levels of serum lipids, lipoprotein cholesterol fractions, and blood pressure. Oral contraceptive use was associated with increased levels of both serum triglycerides (20 mg/dl, blacks; 25 mg/dl, whites) and low density lipoprotein (LDL) cholesterol (19 mg/dl, whites), and decreased levels of high density lipoprotein (HDL) cholesterol (-6 mg/dl, whites). Linear regression analyses also showed that cigarette smoking was associated with elevated levels of serum triglycerides (ranging from 15 to 26 mg/dl) and decreased levels of HDL cholesterol (ranging from -9 to -11 mg/dl) in white males and females. Although persons who smoked cigarettes were also likely to consume alcohol, alcohol intake in nonsmokers was positively associated with levels of serum triglycerides, LDL cholesterol, and very low density lipoprotein cholesterol in white males, and with blood pressure levels in black males. A statistically significant association between alcohol intake and HDL cholesterol levels (r = 0.24) was observed only in white females who did not smoke. These adverse influences of lifestyle factors on cardiovascular disease risk may provide a rational basis for intervention during adolescence and early adulthood.

Adolescent↗
PubMed1986

Transitions of cardiovascular risk from adolescence to young adulthood--the Bogalusa Heart Study: I. Effects of alterations in lifestyle.

Adolescence and young adulthood represents a transition period for biologic and lifestyle characteristics. In a preliminary investigation of young adults (ages 18-20 years), the Bogalusa Heart Study documented patterns of alcohol, tobacco, and oral contraceptive use, as well as changes in education, occupational, marital and parenting status. Such behaviors accelerate the cardiovascular disease process and may differentially influence risk factor patterns of race and sex groups. Adverse levels of systolic blood pressure and alpha-lipoprotein cholesterol were more frequent in married vs single men; elevated triglyceride levels were more frequent in married vs single whites. However adverse levels of beta- and alpha-lipoprotein cholesterol were more frequent in nonparents than in parents. Cigarette smoking and oral contraceptive use were independently related to elevated beta-lipoprotein cholesterol and decreased alpha-lipoprotein cholesterol levels of young white women. Alcohol consumption was highest among white males, with 32% reporting daily consumption of the equivalent of two or more beers or one mixed drink. Alcohol consumption was negatively correlated with blood pressure in white males and positively correlated with alpha-lipoprotein cholesterol in black males. Since such lifestyle factors are related to physiologic risk factors that result in heart disease and adult cardiovascular morbidity and mortality in the older ages, early targeting during adolescence and young adulthood is important.

Adolescent↗
PubMed1986

Cigarette smoking initiation and longitudinal changes in serum lipids and lipoproteins in early adulthood: the Bogalusa Heart Study.

To examine the influence of cigarette smoking initiation on serum lipid and lipoprotein changes in early life, 747 nonsmoking 9- to 17-year-olds from the biracial community of Bogalusa, Louisiana were reexamined five to six years following an initial screening. Upon reexamination in 1981-1983, 147 reported smoking cigarettes (mean duration, 3.5 years; median number of weekly cigarettes, 20). Compared with nonsmokers, persons who began smoking had more unfavorable changes in serum triglycerides and lipoprotein cholesterol levels during follow-up, independently of age, sexual maturation, obesity, alcohol consumption, and oral contraceptive use in females. Smoking initiation was not associated with increases in serum total cholesterol levels, but compared with nonsmokers, white males and white females smoking three or more packs weekly showed additional mean increases of 13.2 and 11.6 mg/dl in low density lipoprotein cholesterol, additional 5.9 and 2.4 mg/dl increases in very low density lipoprotein cholesterol (VLDL-C), and additional decreases of 15.6 and 9.2 mg/dl in high density lipoprotein cholesterol levels, respectively. Black smokers showed larger increases in serum triglycerides and VLDL-C levels than did black nonsmokers. These findings indicate that the start of even modest cigarette smoking may have potentially long-term atherogenic effects. Prevention of smoking in early life should therefore be an important aspect of cardiovascular disease intervention.

Adolescent↗
PubMed1986

Factors associated with adolescent participation in a cardiovascular risk factor assessment program.

A Student Attitude Survey was administered to high school seniors to determine attitudinal and behavioral factors associated with participation in a longitudinal cardiovascular risk factor screening program. Health beliefs, attitudes, and practices were assessed as were altruism, social skills, self-concept, conformity, and academic class standing. Male participants showed higher self-concept scores than non participants. Black participants were younger than black nonparticipants and black participants also showed greater perceived control over their health and more optimistic appraisals of the worth of medical research and practice. White male participants tended to be more likely to remain home from school or to see a doctor when ill. These observations suggest that attitudinal and behavioral factors related to participation in a health-related program can be assessed in childhood.

Adolescent↗
PubMed1986

Longitudinal patterns of cigarette smoking and smokeless tobacco use in youth: the Bogalusa Heart Study.

Tobacco use was studied during 1977-76 (n = 2880) and 1981-82 (n = 2158) in a total biracial community of children, aged 8-17 years, in Bogalusa, Louisiana. White males were the early adopters of tobacco products in both surveys. Cigarette smoking decreased in all race and gender groups while smokeless tobacco use increased in White males. Studies which find a decline in male adolescent smoking should investigate a possible concurrent increase in smokeless tobacco.

Adolescent↗
PubMed1985

A method to assess the environment for genetic studies: the Common Environment Index and the Household Relationships Interview.

Genetic and environmental influences in causing a disease are difficult to measure because of lack of precision in identification of relevant nongenetic variables. The Household Relationships Interview and Schedule was developed to measure shared common environment in families (Common Environment Index) and to take into account developmental stages throughout the life cycle and separation/disruption. Seven trained persons interviewed three individuals who reported fictitious interrelated life histories varying in length and complexity. Discrepancies between the recorded data and the true data were analyzed. Overall 96.1% of the items were recorded correctly. Thus, the method has shown good face and construct validity and reliability for measuring quantity of time shared by relatives in a common household. Common environment as measured by this instrument should be a particularly useful tool in behavior-genetic studies.

Environment↗
PubMed1985

Cigarette smoking behavioral distinctions between experimental nonadopters and adopters in children and adolescents--a consideration of transitional smoking experience: the Bogalusa Heart Study.

A cigarette-smoking questionnaire to examine behavior, attitudes, and beliefs related to cigarette use was administered to children, ages 8-17, in a biracial community. Children who experimented with cigarettes but did not adopt the habit (experimental nonadopters) and children who continued to smoke (adopters) were identified and characterized. Follow-up behavior was examined 2 years later. Adopters were more likely to have smokers as friends and family members, more likely to have purchased their first cigarettes, more likely to believe smoking to be pleasurable for themselves and others, and less likely to consider smoking harmful. Adopters who maintained smoking behavior 2 years later had, during the initial survey, reported having more friends who also smoked and were more likely to believe smoking to be enjoyable. Experimental nonadopters were more likely to try the first cigarette alone, reported having fewer friends and family members who smoked, and believed greater health risks to be associated with cigarette use. Experimental nonadopters who maintained nonsmoking behavior 2 years later, especially in the older cohort, exhibited higher agreement with the negative consequences of cigarette smoking (health beliefs) and theories concerning smoking behavior of others.

Adolescent↗
PubMed1985

Measurement assessment of the type A coronary prone behavior pattern and hyperactivity/problem behaviors in children: are they related? The Bogalusa Heart Study.

The purpose of this study was to contribute to concept clarification regarding identification of the Type A behavior pattern in children. To accomplish this, two measurement techniques for assessing Type A behavior in children (MYTH and Hunter-Wolf) were compared to a third (a teacher-rated measure of hyperactivity: the Conners), since this latter measure, although often used to diagnose hyperactive children, seemed also to measure some Type A-like behaviors. The Hunter-Wolf also included a self-assessment of Type A behavior. The conceptual and measurement issue was: Are teachers rating Type A or hyperactive/problem behaviors in children? Fifty-five teachers participated. They rated 253 students, aged 8 to 17 years, in a biracial community. The clear overlap between teacher-assessed Type A and the Conners hyperactivity measure was demonstrated when the best predictor of teacher-assessed Type A measure was the Conners. This was especially true for black males and white females. Little relationship existed between teacher-assessed Type A and self-assessment. The conclusions suggest that implications drawn from teacher-assessed Type A behavior in children may be inadequate because of potential ethnic and gender artifactual measurement error.

Adaptation, Psychological↗
PubMed1982

Cardiovascular risk factors in children. Should they concern the pediatrician?

There is evidence that atherosclerosis, coronary artery disease, and essential hypertension begin early in life. The Bogalusa (La) Heart Study has examined cardiovascular risk factors and their determinants during the pediatric age span in a total community study. Reliable measurements were obtained and then analyzed to identify "tracking" of risk factors over time and clusters or aggregations of various risk factors at high levels. Serum lipoprotein levels, obesity, BP, and plasma insulin levels were all correlated after a glucose load, implying causal interrelationships. Although such relationship are only partly elucidated, the associations potentially enhance premature atherosclerosis. Certain kinds of behavior, for example cigarette smoking and type A behavior, may also contribute to early coronary artery disease. Our observations suggest that practicing physicians should assess risk factors in children and encourage changes in life-style to combat the high incidence of coronary artery disease and essential hypertension in the United States.

Adolescent↗
PubMed1982

Type A coronary-prone behavior pattern and cardiovascular risk factor variables in children and adolescents: the Bogalusa Heart Study.

The relationship between Total score from the Hunter-Wolf A-B Self-Rating Scale for children (and derived Factors) and several cardiovascular risk factor variables was observed in children ages 10-17 in a biracial community. After analysis, effects of age, weight and height were removed from the Total A-B score, each Factor score, and risk factor variable. Differences in risk factor variables were observed in relation to A-B, race and sex. For each sex-race group, the four Factor scores and Total score were ranked into quintiles. Children in the upper quintile referred to as Type A children and those in the lower quintile, Type B. For Factor 1, which describes eagerness and energy in children (Eagergy), significant mean differences were found for serum total, beta- and pre-beta-lipoprotein cholesterol and triglycerides. In each instance, children classified as Type A exhibited approximately 10 mg/dl higher readings, except for pre-beta-lipoprotein cholesterol in which a 2 mg/dl difference was noted. Two significant second order interactions were found for systolic and diastolic blood pressure. Black boys who scored in the A direction had higher systolic blood pressures, while Type A girls had higher diastolic blood pressures than their Type B counterparts (p less than 0.05). For Factor IV, which is related to feeling hurried, there was an approximate 10 mg/dl difference in serum total and beta-lipoprotein cholesterol in the direction opposite to that predicted. Although the relationships between A-B coronary behavior pattern and risk factor variables in children are of low magnitude, the relationships are being observed in the direction that might be predicted. Measurement of Type A in children requires further refinement in concept identification and valid measurement.

Adolescent↗