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Biomedical subjects

S M Gupta

Publications and source records attributed to S M Gupta.

At least 73 records · Page 4Linked to original sources
PubMed1982

Radiocolloid studies of the regression of intrasplenic lesions.

Five cases are presented in which intrasplenic defects, noted on Tc-99m sulfur colloid imaging, had at least partially regressed on follow-up studies. One, representing splenic trauma, reinforced the concept of the ability of the spleen to "heal" itself. A second case involved splenic invasion by direct extension of a soft tissue sarcoma. Improvement was noted after the patient was treated with chemotherapy. Three cases were related to splenic manifestations of lymphoma. Of these three patients (one each with lymphocytic, histiocytic, and mixed diffuse histiocytic lymphoma plus nodular), two showed improvement after treatment with chemotherapy alone and the third after combined chemotherapy and external radiation treatment. Return of splenic reticuloendothelial function to previously involved regions within the spleen occurred for all five patients. Comments were made as to the apparent rate of return of function.

Aged↗
PubMed1982

Radionuclide scanning for the rapid diagnosis of acute cholecystitis.

Radionuclide scanning with Technetium 99-m HIDA was performed in eighty-nine patients with suspected acute cholecystitis. In twenty-three patients (25.8%), the study demonstrated evidence of cystic duct obstruction and non-visualisation of the gallbladder. Almost all of these patients subsequently were shown to have acute cholecystitis at surgery. The sensitivity and specificity of the procedure for the diagnosis of acute cholecystitis was 95.8% and 100% respectively. The use of radionuclide cholescintigraphy in the assessment of hepatobiliary disorders is reviewed, and it is suggested that it is the test of choice at present for diagnosis of acute cholecystitis.

Acute Disease↗
PubMed1982

2-Mercaptopropionylglycine protection against growth-inhibiting effects in utero irradiated mice.

Pregnant Swiss albino mice at different fetal growth periods were exposed to 150 R gamma rays in the presence or absence of 2-mercaptopropionylglycine (MPG), a SH radioprotector. The weights of litters born to these mothers were recorded at different postpartum intervals. There was an initial weight loss at 1 week after birth followed by a second weight loss after 4 weeks in the unprotected control males, whereas females showed continuous gains in weight from initial loss at 1 week. In the MPG-treated groups, the pattern of weight changes remained the same, but the loss was significantly less than in the controls and the second weight loss in the case of males was not obvious.

Amino Acids, Sulfur↗
PubMed1981

Radioprotective effect of MPG (2-mercaptopropionylglycine) on the postnatal growth of mice irradiated in utero.

Pregnant mice at gestation days 14 1/4, 16 1/4 and 18 1/4 were exposed to 250 R gamma rays in presence and absence of MPG, a -SH radioprotector. There was a biphasic weight loss in post partum animals born to irradiated mothers. In the MPG treated young ones, the second weight loss was remarkably averted. It was also found that 14 1/4 day of gestation was more radiosensitive than 16 1/4 or 18 1/4 days.

Amino Acids, Sulfur↗
PubMed1980

An evaluation of geriatric service in a public hospital.

A retrospective survey of the one and half years between 1975-77 was conducted to evaluate the medical problems of the elderly in a community served by a large urban public hospital. Medical records of 238 patients were scrutinised to assess the incidence of most common diseases, their outcome and the success of rehabilitation programme. There were more females (58.4%) than males (41.6%) and the mean age of patients was 78 years. The cerebrovascular problems were the commonest followed by cardiovascular and musculoskeletal disorders. Majority of the patients, however, had multiple problems. Twenty-eight percent of the patients died in the hospital and of the remaining, 83% were successfully rehabilitated. A large number of the patients discharged home needed provision of domiciliary services in the early stages and the readmission rate was 3%.

Aged↗
PubMed1980

Significance of diffuse pulmonary uptake in radiogallium scans: concise communication.

Diffuse pulmonary uptake of radiogallium was observed in 50 out of 510 scans (9.8%) performed in a general hospital over a period of 1 yr. Of the 50 cases, 80% had bilateral, diffuse distribution, and 20% unilateral. A variety of clinical conditions produced a similar picture on the pulmonary images. The most common cause of the diffuse uptake was infectious disease (48%) followed by infiltrative disorders (30%) and neoplastic conditions (22%). On a repeat study there was significant reduction in the intensity of pulmonary radiogallium uptake following drug therapy in three patients--sarcoidosis on corticosteroid therapy, pneumocystis carinii treated with trimethoprim and sulfamethoxozole, and interstitial pulmonary fibrosis on corticosteroids. No close correlation was observed between the underlying clinical disorder and the pattern or intensity of pulmonary uptake of radiogallium.

Alveolitis, Extrinsic Allergic↗
PubMed1980

Pathogenesis of jaundice in histiocytic medullary reticulosis. A correlative scintigraphic, histologic and biochemical study.

Liver scanning with 131Iodine Rose bengal was performed on two patients with histiocytic medullary reticulosis. The diagnosis was confirmed in both cases on subsequent autopsies. The studies demonstrated obstructive pattern in both cases on scanning and correlated well with the biochemical and histological findings. The pathogenesis of jaundice in this condition is reviewed and it is suggested that intrahepatic obstruction plays a significant role in its causation.

Aged↗