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Biomedical subjects

S Larsson

Publications and source records attributed to S Larsson.

At least 379 records · Page 21Linked to original sources
PubMedDate not supplied

Amino acids in the neuronal microenvironment of focal human epileptic lesions.

Extracellular fluid was topically sampled with a dialysis probe during electrocorticography from the exposed cerebral cortex in 23 patients undergoing epilepsy surgery. Sampling was done in parallel from epileptiform regions and from non-epileptic areas. The former were classified according to the histopathology, into neoplastic, non-tumoral or 'special cases'. The epileptiform regions had significantly higher extracellular concentrations of alanine, glycine and phosphoethanolamine in the majority of the cases. The excised epileptic lesions were analyzed to provide the corresponding intracellular concentrations of amino acids. Several of the non-tumoral group showed high concentrations of GABA, ethanolamine and alanine. The intra- to extracellular concentration ratio for amino acids was low for phosphoethanolamine, glycine, serine and glutamine in most of the samples of epileptiform cortex, while the intracellular accumulative ability for ethanolamine apparently was stronger in epileptiform than in normal cortex.

Adolescent↗
PubMedDate not supplied

Arthroscopic lavage compared with nonoperative treatment for traumatic primary anterior shoulder dislocation: a 2-year follow-up of a prospective randomized study.

A prospective randomized study was performed on 30 consecutive patients with traumatic primary anterior shoulder dislocation to compare treatment results of arthroscopic lavage with results of conventional nonoperative treatment. The patients were between 18 and 30 years of age and had no history of shoulder problems. At the 2-year follow-up, 3 (20%) of 15 patients in the lavage group had a redislocated shoulder compared with 9 (60%) of 15 patients in the nonoperative group (P = .03). Two of the patients in the lavage group compared with 6 of the patients in the control group had been operated on or were scheduled for stabilizing surgery. Functional outcome according to the Constant and Rowe shoulder scores did not reveal any significant difference (P = .07) between the groups. However, by the Rowe classification 2 of 15 patients in the lavage group had poor results versus 8 of 15 in the control group, indicating an advantage for the lavage treatment. The study showed that arthroscopic lavage reduced the risk for recurrent dislocation when compared with nonoperative treatment.

Adolescent↗
PubMedDate not supplied

Introduction: the need for a multidimensional and multidisciplinary approach.

This special issue combines contributions from several disciplines within the social sciences on how to understand long-term use or dependency on various kinds of psychotropics. It emphasizes the need for a multidisciplinary approach in order to understand the complexity of such long-term use. The papers in this issue will base their arguments on psychological, sociological, anthropological, clinical, and social pharmacy perspectives. Different disciplines focus specially on certain topics. For example, psychology can help us to understand what kind of mental processes that are involved in the development of long-term tranquillizer use. Sociology, anthropology and social pharmacy have a particular contribution to make in helping us, in different ways, to understand the social meanings of psychotropic drug use.

Anti-Anxiety Agents↗
PubMedDate not supplied

Identity, cognitive structure, and long-term tranquillizer use: a multidimensional approach.

The article discusses different theoretical perspectives that are relevant in analysing long-term tranquillizer use. The theories mentioned are, e.g., behavioral theory models, cognitive models, humanistic and existential models, transpersonal identity models, psychodynamic reasoning, sociological and anthropological perspectives. A multidimensional model focusing on the connection between identity structure and long-term tranquillizer use is presented. The article argues for the use of mixed methodological strategies, e.g., quantitative and qualitative methods. The implications of the 'actor-spectator paradox" for the analysis of data are also discussed in some detail.

Anti-Anxiety Agents↗
PubMedDate not supplied

Experiences of long-term tranquillizer use: a psychodynamic perspective.

The aim of the article is to analyse narrative descriptions and experiences of long-term tranquillizer use. The analysis is based on a Danish in-depth study of 50 informants with a self-diagnosed dependency on tranquillizers. The theoretical analysis is dependent on psychodynamic reasoning. Further, the psychodynamic perspective is integrated within a multi-dimensional model that considers biological, cognitive, identity, gender and social learning factors. The analysis reveals the possibility of achieving a detailed understanding of the dynamic processes involved in the development of long-term tranquillizer use. Important themes frequently mentioned in the clients' descriptions are traumatic childhood experiences, identity problems, life crises in adulthood and difficulties in stopping taking psychotropic drugs.

Adult↗
PubMedDate not supplied

Evaluation of programs for the treatment of benzodiazepine dependency.

Programs for the treatment of benzodiazepine dependency differ in a number of ways. Their outcome goals, for example, vary. In some of the programs the reduction or the elimination of benzodiazepine use is the main objective. In others a reduction in anxiety and depression among patients is regarded as much more important than decreasing benzodiazepine use. These differences in goals make comparative evaluations difficult. Further, the type of clients recruited to the programs are often dissimilar. However, it is still possible and valuable to make comparative evaluations of the numerous programs. The aims of published evaluations differ. Most evaluations are directed towards outcome data. Only in a few studies has the aim been to analyze the dynamic treatment process. To achieve more reliable and valid evaluations it is necessary to get data which describe the process and the results from both the clients' and the therapists' perspectives and combining different research strategies.

Anti-Anxiety Agents↗
PubMedDate not supplied

Toward an integrative approach in the analysis of dependency problems.

This article takes some preliminary steps towards an integrated analysis of dependency problems e.g., long-term tranquillizer use, alcohol dependence, problematic use of narcotics. It argues for the need to outline important theoretical, epistemological, and methodological prerequisites in the analysis of the complex dynamic developmental processes involved in dependency problems. The dynamic process leading to dependence can be studied by the aid of an artificial science neural network approach in combination with a mixed method strategy including a clarification of a combination of different epistemological positions. It is intended that the empirical output of this complex strategy will provide a starting point for a new theoretical analysis which, in turn, will lead to new and more relevant input variables in the neural network approach that will help us to extend our knowledge of the dynamic processes leading to dependency.

Comorbidity↗
PubMedDate not supplied

Epilogue: drawing together the threads and perspectives on the long-term use of psychotropics.

The aims of the epilogue are to draw together the threads in this issue by reviewing some themes presented in the previous chapters and to consider the relationship between the perspectives mentioned. The implications of a multidimensional perspective for future research, treatment and prevention are discussed. It is emphasized that the social sciences have an important part to play in helping us understand long-term use of psychotropics. The social sciences provide insights of importance for research, treatment and prevention of dependency on psychotropics, and also, may help us deal better with these kind of problems in the future.

Anti-Anxiety Agents↗
PubMedDate not supplied

Prevalence of incidental paranasal sinuses opacification in pediatric patients: a CT study.

A prospective evaluation of the paranasal sinuses was performed on a consecutive series of 137 pediatric patients referred for cranial CT. Approximately one-half of the patients less than 13 years of age had some degree of maxillary or ethmoid sinus opacification. The prevalence and severity of opacification was approximately the same for the maxillary and ethmoid sinuses. Sphenoid sinus abnormality was less common (16% of patients) and was usually minimal or mild. No incidental frontal sinus abnormalities were observed. This study confirms previous reports, based on plain film radiography, of the prevalence of incidental maxillary sinus opacification in children. However, contrary to some prior studies, we did not find a relatively higher rate of opacification in children less than 1 year of age. This may be due to overdiagnosis of maxillary sinus opacification on plain films, in small children. The diagnosis of sinusitis in childhood must take into account not only the radiographic findings but clinical signs and symptoms. Correlation is needed to avoid overdiagnosis in patients referred for sinus radiography for nonspecific indications or who have incidental opacification noted on radiographic or CT studies of the skull and brain.

Adolescent↗
PubMedDate not supplied

Shrinking pleuritis with atelectasis. Specificity of abnormalities present at conventional radiography of the lung.

Radiographic appearances claimed to be typical of shrinking pleuritis with atelectasis (SPA) were tested by mingling chest films from 6 SPA patients with those from 56 cancer cases. Two radiologists were asked to interpret the films independently, make a diagnosis, and state what abnormalities could be distinguished. No single abnormality or combination of abnormalities was found to be pathognomonic and the wish to diagnose the SPA cases led to misdiagnosis of cancer in one of 56 cases by each radiologist. To prevent underdiagnosis of cancer, further examinations are required. Careful follow-up of SPA cases, if they are not operated upon, is recommended.

Diagnosis, Differential↗
PubMedDate not supplied

Radioiodine uptake in the head and neck.

OBJECTIVE: To report two cases of sinusitis-associated radioiodine uptake in patients with thyroid cancer and to review the reported causes of false-positive radioiodine uptake in the head and neck area. METHODS: We present the radiologic findings in two patients who had undergone treatment for papillary thyroid cancer and discuss other settings in which radioiodine uptake suggested the presence of metastatic disease. RESULTS: Radioiodine whole-body scans of two patients who had had thyroid cancer demonstrated uptake in the sphenoid and maxillary sinuses, respectively, mimicking bone or brain metastatic involvement. The thyroglobulin levels were low. Computed tomographic (CT) scanning disclosed mucosal swelling in the sinuses, consistent with sinusitis. The radioiodine uptake cleared on a follow-up scan in one case and was more localized than the CT findings in the other. Eighteen causes of false-positive radioiodine uptake in the head and neck area have been reported. On the basis of the mechanism of uptake, they can be classified into four categories: (1) physiologic uptake (ectopic thyroid tissue), (2) nonthyroidal pathologic conditions (dacryocystitis, sinusitis, sinus mucocele, sialadenitis, folliculitis, Warthin's tumor, parotid cyst, porencephaly, posttraumatic cerebromalacia, and inflammation due to dental disease or a nose ring), (3) internal retention (ectasia of the carotid artery and an artificial eye), and (4) external contamination by body secretions (sweat and nasal, tracheobronchial, lacrimal, and salivary secretions). The estimated prevalence of external contamination in the head and neck area on whole-body radioiodine scans is 0.3%. CONCLUSION: Physicians should rule out the presence of radioiodine uptake by inflamed mucosa of the paranasal sinuses, as well as various other causes of false-positive radioiodine uptake, before metastatic thyroid cancer in the head and neck area is diagnosed.

Carcinoma, Papillary↗
PubMedDate not supplied

Replacement of the oesophagus with a segment of colon experience of 30 cases and technical considerations.

Thirty consecutive patients who underwent oesophageal replacement with a segment of colon (16 for malignant and 14 for benign disease) were reviewed. The operation was done in one stage in 28 cases and in two stages in two. The interposed colon was always placed isoperistaltically, in the bed of the oesophagus in 24 and retrosternally in 6 cases. In seven patients a valve was constructed to prevent gastrocolic reflux. There was one early postoperative death (3%). Early non-fatal complications occurred in 5 (17%), and late complications in 6 patients (20%). The functional results were excellent to good in 21 (73%), acceptable in 7 (24%), and poor in 1 (3%). The data suggest that colonic interposition offers a good alternative to stomach in selected cases with oesophageal malignancy and represents an excellent choice for reconstruction in benign oesophageal disease.

Colon↗