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Biomedical subjects

S Larsson

Publications and source records attributed to S Larsson.

At least 307 records · Page 17Linked to original sources
PubMed1980

Husfeldt hernia repair: indications and results. A follow-up study.

Ninety-seven consecutive patients with hiatal hernia were operated upon with a modified Husfeldt hernia repair during a ten-year period. Thirty-two of the patients had severe reflux complications, such as ulcerative oesophagitis, oesophageal stricture and shortened oesophagus. Ninety patients were carefully followed up postoperatively. The mean duration of follow-up was 5 years. Analysis of the postoperative results in relation to the type of hernia showed no difference between sliding and combined hernia. Recurrence of hernia, unsatisfactory clinical results and gastro-oesophageal reflux were recorded more often in patients with severe reflux complications. The main cause of unsatisfactory results in these patients was found to be a shortened oesophagus. The method proved to be a reliable procedure for surgical treatment of not only uncomplicated hernias, but also cases complicated by oesophageal stricture if the stricture was not associated with shortened oesophagus. It is considered that a shortened oesophagus is a contra-indication for employment of the Husfeldt method.

Adolescent↗
PubMed1979

Outcome of Listeria monocytogenes infection in compromised and non-compromised adults; a comparative study of seventy-two cases.

The mortality in listeric meningitis and septicaemia, the two main clinical manifestations of the infection, is generally considered to be high. However, co-existing disorders rather than the listeric infection itself seem to determine the outcome. In the present study of 72 listeric infections among non-pregnant adults, 28 patients without co-existing disease had a fatality rate of 10.7% as compared to 57.9% among 19 immunocompromised individuals. Finally, in a third group of listeric patients, including alcoholics and people with heart disease or diabetes mellitus, the fatality rate was 24.0%.

Adult↗
PubMed1979

Our experience with the Carpentier-Edwards bioprosthesis.

Sixty Carpentier-Edwards porcine valve bioprostheses stabilized with glutaraldehyde were implanted in 55 patients with acquired and congenital heart disease. The follow-up period ranged between 1 and 12 months. There were 3 hospital deaths (5%) and 2 late deaths (4%) in 24 mitral, 24 aortic, 5 mitral-aortic, 1 tricuspid and 1 pulmonary valve replacements. All patients were anticoagulated from the second postoperative day onwards for a period of 3 months after which those with sinus rhythm had their anticoagulants withdrawn. Paravalvular leakage led to re-operation in 3 cases (4%). No valve failure due to cusp rupture was encountered and no thromboembolic complications have occurred. Thirty-three patients were studied postoperatively by non-invasive methods and the results are presented.

Adolescent↗
PubMed1979

Epidemiology of listeriosis in Sweden 1958--1974.

In 1958--1974 altogether 110 cases of listeriosis were diagnosed in Sweden by culture. 64 cases were seen in children and adults. Of these, 52 had manifestations of meningoencephalitis and 10 of septicemia. Another 46 cases were seen in pregnant women and/or their neonates. Pregnancy ended in abortions in 8 cases and in stillborns in 3. Out of 37 neonates born alive, 22 had "early disease", mostly granulomatosis infantiseptica, and 8 had "late disease" with meningoencephalitis. The reported frequency of listeriosis in humans showed no correlation with that in animals. With the exception of pregnant women the incidence and mortality showed no difference with sex. Serotypes 1 and 4b prevailed and were equally common. The serotype did not vary with the clinical diagnosis or the outcome. There was no seasonal variation. Cases of all serotypes were uniformly distributed over the country in proportion to the density of its population. Occupational contact with animals was less common. Only in a few cases was there reason to suspect infection from animals. Co-existing disorders predisposed for the disease and often determined its outcome. Neonates with early onset of disease were infected by their mothers, while neonates with late onset of disease were infected from other and often nosocomial sources.

Abortion, Septic↗
PubMed1979

Correlations between clinical and postmortem findings in listeriosis.

Clinical data were correlated with postmortem findings in 14 cases of fatal listeriosis in adults and 23 cases of listeriosis during pregnancy and the neonatal period. Most children born with congenital listeriosis showed the typical morphological picture of granulomatosis infantiseptica. Occasionally no pathological changes were demonstrable. In adult patients the morphological lesions were those of non-specific purulent meningoencephalitis or septicemia. Sometimes encephalitis with abscesses in the brain was found.

Abortion, Septic↗
PubMed1978

Detection of atherosclerotic plaques in carotid arteries by the use of 123I-fibrinogen.

A non-invasive method for detecting atherosclerotic plaques by the administration of radioactively labelled fibrinogen has been used in a pilot study in one non-atherosclerotic patient and in four patients with unilateral or mainly unilateral atherosclerotic changes. Immediately after 1 mCi 123I-labelled fibrinogen had been given intravenously, the cervical region was examined with a gamma camera and again after 4 h and 20 h. In the control case there was little difference in activity between the left and right carotid regions. The other cases showed a significant increase of activity over the region of the plaque after 4 h. This increased uptake had disappeared after 20 h. Studies to clarify the nature of this uptake and the usefulness of the method are in progress.

Adolescent↗
PubMed1978

Tumors of the thymus and thymic region: I. Clinicopathological studies on thymomas.

A series of 43 patients with thymoma was reviewed. The patients were classified with respect to some factors of prognostic significance. The tumors were reclassified histologically, and a staging system with three defined stage-groups was applied to the series on the basis of operative findings and histological examination of surgical specimens. Surgical-pathological staging is of high prognostic and therapeutic importance in thymomas. Complete removal of the tumor was possible in the 25 patients with stage I or II disease and in 14 of the 18 patients with stage III tumors. Pleural metastases were observed in half of the patients with stage III disease. Even patients with extensive local spread or pleural metastases were subject to tumor resection. The treatment of choice is radical resection along in stage I; radical extirpation and, if indicated, postoperative radiotherapy in stage II; and radical resection whenever possible, even in cases of pleural spread, in stage III, with postoperative radiotherapy and chemotherapy. Myasthenia gravis is an indication rather than a contraindication to radical treatment of thymoma, although some patients may deterioratte. The importance of total thymectomy is stressed.

Adolescent↗
PubMed1978

Tumors of the thymus and thymic region: II. Clinicopathological studies on Hodgkin's disease of the thymus.

Among 82 patients with a tumor in the thymic region, 17 had a lesion that fulfilled the criteria for Hodgkin's disease of the thymus; the histopathological differentiation of this entity from thymomas is discussed. All patients received surgical treatment and postoperative radiotherapy. After a mean observation time of 10 years there was no local recurrence and no death due to the disease, though 3 deaths were cuased by the treatment. New clinical manifestations occurred in 3 of the 14 long-term survivors: they were treated successfully by operation or irradiation. A very aggressive surgical approach involving extirpation of all tumor tissue, extensive excision of the surrounding tissues and adjacent lymph nodes, and supplementary radiotherapy seems to be the treatment of choice.

Adult↗