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Biomedical subjects

S Larsen

Publications and source records attributed to S Larsen.

At least 433 records · Page 24Linked to original sources
PubMed1980

Estrogenic response in women with amenorrhea during treatment with human menopausal gonadotropin with and without the simultaneous administration of bromocriptine.

In an attempt to determine whether prolactin influences estrogen biosynthesis in the ovary, the estrogenic responses of women with amenorrhea under treatment with human menopausal gonadotropin (hMG), with and without the simultaneous administration of the prolactin inhibitor bromocriptine, were investigated in a total of 20 treatment cycles. In five of the six women studied, the addition of bromocriptine produced a urinary excretion of estrogenic compounds 79% higher than that produced by treatment with hMG alone. In one woman with a slightly increased serum prolactin level, the addition of bromocriptine necessitated halving the total hMG dosage. One woman with low endogenous levels of follicle-stimulating hormone (FSH) and a limited response to gonadotropin-releasing hormone showed no increased estrogen excretion after bromocriptine administration over that produced by hMG alone. These results suggest that (1) both elevated and normal serum prolactin levels can have a direct inhibitory effect on the ovary and (2) FSH may be necessary for the formation of prolactin receptors in the ovary.

Adult↗
PubMed1980

School contact between patients with multiple sclerosis.

We have investigated whether there was more school contact among patients with multiple sclerosis (MS) than expected by chance, suggesting that a transmissible infection occurring at school age might be an aetiologic factor. A case-control-within-a-cohort study was conducted using the 1930-1950 birth cohort. Of 198 000 persons 92 had developed MS in the period 1943-1975 and 3 matched controls for each case were selected. The number of links between all possible pairs of cases was estimated, as well as the number of cases involved in contact with at least one other case. Three measures of school contact were included in the analysis. No evidence of increased school contact among MS cases relative to controls was found.

Adolescent↗
PubMed1980

Pre-morbid factors in Hodgkin's disease III. School contact between patients.

The question whether there is more school contact among patients with Hodgkin's disease (HD) than expected by change, suggesting that the disease might be transmissible, has been the object of several recent studies. Our study was based on the birth cohort 1930-1950 from the register of records from the school health service of the Copenhagen City Council. The cohort contains about 198 000 persons, and 65 of these had developed HD before age 40 years and in the period 1943-1975. For 62 patients, 3 matched controls for each were selected in the register, and for the remaining 3 patients at least 1 control for each was found. We analysed 36 combinations of contact measures and subsamples, and found no excess of school contact in patients relative to controls. The finding adds to the evidence against the hypothesis that HD is transmitted at school age from one future patient to another, or from a small pool of carriers.

Adolescent↗
PubMed1980

Ironstrene (ferric sodium edetate) treatment of anaemic infants.

This study deals with haemoglobin (Hb) measurements of healthy 1-year-old children in one district in central Norway. The aim was to study the Hb levels, to treat any children having iron deficiency anaemia (Hb less than or equal to 10.8 g/100 ml), and to evaluate the effect of sodium iron edetate after 4 weeks of treatment, with a follow-up after 1 year. A total of 141 children were examined, of whom 40 had Hb less than or equal to 10.8 g/100 ml (28.4%). The study showed that the Hb levels in healthy 1-year-olds have a normal distribution. Thirty-four children with Hb less than or equal to 10.8 g/100 ml were treated for 4 weeks with sodium iron edetate (six drop-outs). The study showed a significant increase in Hb levels immediately after the treatment period as well as 4 weeks later. Hb decreases significantly immediately after ceasing treatment and continues to do so during the control period of 1 year. The Hb levels probably increase to a maximum 2 weeks after the treatment period.

Anemia, Hypochromic↗
PubMed1980

Inhibition of the histamine-stimulated gastric secretion in healthy subjects by the H2-receptor antagonist ranitidine.

The gastric secretion was examined for 30 min before and 120 min during intravenous infusion of 3 microgram/kg/h of histamine dihydrochloride. In eight subjects physiological saline solution was given as infusion in addition to histamine (controls), whereas nine subjects received ranitidine in doses increased every half hour--0.06, 0.12, 0.24, and 0.48 mg/kg/h. The infusion of ranitidine resulted in a significant reduction of volume of gastric juice both when compared with the unstimulated periods before histamine and with those of subjects receiving the saline solution. Similarly, the acid output was reduced still more significantly during infusion of ranitidine, the output being about zero in the last hour. The ranitidine dose used was about five time lower than that previously used of cimetidine. No side effects were observed.

Adult↗
PubMed1980

Studies of the choledocho-duodenal sphincter in patients with and without juxta-papillary duodenal diverticula.

The function of the choledocho-duodenal sphincter was studied in 16 patients, 8 with juxta-papillary duodenal diverticula. All patients had calculi in the gallbladder. The common bile duct was normal. At cholecystectomy two catheters were introduced into the common bile duct through the stump of the cystic duct and fixed in place. The examinations were performed when the patients had recovered from the operation. One catheter was connected to a pressure transducer, the other was used for saline infusions. Pressure in the common duct was recorded before infusion and at constant infusion rates of 3,6, and 12 ml/min. The muscular tone, the contractile activity, and the total rhythmic variations of the sphincter during infusions were all significantly less in patients with diverticula than in the controls without diverticula. The findings indicate that there is a dysfunction of the choledochoduodenal sphincter in patients with juxta-papillary duodenal diverticula. This may in part be responsible for the high incidence of biliary calculi in patients with duodenal diverticula.

Aged↗
PubMed1980

Acetylsalicylic acid-induced gastrointestinal bleeding determined by a 51Cr method on a day-to-day basis.

The daily gastrointestinal blood loss caused by plain and microencapsulated acetylsalicylic acid (ASA) tablets was compared. Fourteen healthy, male volunteers participated in a double-blind, cross-over study, lasting 38 days. Before drug administration a median gastrointestinal bleeding of 0.9 ml/24 h was observed. During oral intake of 1.5 g ASA twice a day for 5 days, an increased faecal blood loss was seen in all volunteers. The increase was significant for both plain and microencapsulated ASA (p less than 0.01). Plain ASA tablets, however, caused a greater faecal blood loss than the microencapsulated tablets (p = 0.05), maximum median levels being 6.2 ml/24 h and 3.9 ml/24 h, respectively. An optimal design of radiochromium studies for determination of drug-induced gastrointestinal blood loss is discussed.

Adult↗
PubMed1980

Exocrine pancreatic secretion and immunoreactive secretin release after repeated intraduodenal infusions of bile in man.

The exocrine pancreatic secretion of water, bicarbonate, amylase, trypsin, chymotrypsin, and lipase and the plasma concentration of immunoreactive secretin (IRS) were studied before and after repeated intraduodenal infusions of cattle bile in man. After endoscopic cannulation of the main pancreatic duct, juice was collected in 5-min samples for 20 min. A solution of 6 g dried cattle bile in 60 ml water was then infused into the duodenum through a separate catheter attached to the outside of the duodenoscope. Juice was collected for another 20 min. After this period a solution of 6 g dried cattle bile in 40 ml water was infused into the duodenum, and juice again collected for 20 min. Blood was frequently drawn from an arm vein for estimation of plasma concentration of secretin by radioimmunoassay. Both bile infusions caused significant rises in flow rate, bicarbonate concentration and output, and IRS (p less than 0.05). Enzyme concentrations decreased significantly after intraduodenal bile infusions (p less than 0.05). Outputs of enzymes rose significantly after the first bile infusion; however, a rise after the second bile infusion was found only for amylase. Further, a significant decrease in amylase and lipase concentration was found after the second bile infusion. The findings indicate that the increase in proteolytic enzyme and lipase secretion was due to a washout phenomenon. The increase in the plasma concentration of secretin after repeated bile infusions, with a corresponding effect on flow rate and bicarbonate secretion, indicates that secretin may be the main factor responsible for the exocrine pancreatic secretion caused by intraduodenal bile infusions.

Adult↗
PubMed1980

Renovascular hypertension treated by autotransplantation.

Renal autotransplantation was performed in 16 patients with severe renovascular hypertension. The hypertension was cured in 13 patients, 2 patients were improved and one patient had no benefit. The postoperative function and morphology of the transplanted kidneys remained unchanged. In our view, renal autotransplantation is a valuable method in the surgical treatment of renovascular hypertension.

Adult↗
PubMed1980

The significance of pH variations in human albumin perfusion media during continuous hypothermic renal perfusion.

The variation of pH in perfusate during renal machine perfusion has been regarded exclusively as an effect of kidney metabolism. During preservation of 21 canine kidneys for 48 hours in a Gambro PF-2D machine the pH was measured in the human albumin perfusion medium used, and in control samples stored a 4 degrees C. An increase in pH from 7.21 (+/- 0.03) to 7.66 (+/- 0.10) was found in the machine perfusate. In the stored perfusion medium an increase from 7.21 (+/- 0.03) to 7.43 (+/- 0.20) was measured. We conclude that the pH change in perfusate is not a reliable parameter for the functional state of the kidney unless the spontaneous pH variation in the perfusion medium is simultaneously recorded and a correction made.

Albumins↗
PubMed1980

Trimipramine in the treatment of duodenal ulcer. A multicenter, open study.

Sixty patients with endoscopically confirmed duodenal ulcers were treated with 50 mg of trimipramine daily. After the end of the treatment 45 patients showed healed ulcers. Ulcer healing was not related to serum concentration of trimipramine, but seemed to be influenced by smoking habits and duration of the total and actual disease history.

Antacids↗
PubMed1980

Trimipramine and duodenal ulcer.

The gastric acid secretion, fasting serum gastrin and serum concentration of trimipramine were studied in 20 patients with duodenal ulcer during a 6 weeks treatment with trimipramine. Ulcer healing was examined endoscopically. In the group of 11 patients with healed ulcers the gastric acid secretion decreased significantly at 3 and 6 weeks in contrast to the 9 patients in whom ulcers did not heal, indicating a different antisecretory response in the two groups. The serum concentration of trimipramine was similar in both groups during treatment. Possible mechanisms of action of trimipramine in peptic ulcer disease and problems concerning clinical response and dose are discussed.

Adult↗
PubMed1980

Survival of discordant renal xenografts up to 3 days assessment of function, light and immunofluorescent microscopy.

This study concerns the pathology of renal xenografts with prolonged survival, achieved by administering Cobra venom factor. Rabbit kidneys transplanted to cats survived up to 72 hours after transplantation when Cobra venom was administered--whereas survival was only about 10 minutes in untreated animals. This marked prolongation of survival--apparently longer than has been reported previously--gave very favourable conditions for the study of morphological changes in the renal xenografts, and we are able to describe the pathology of xenografts after minutes, hours and days of function. There were two principal findings in the group of long-surviving kidneys: :1) immunereactants were only sparsely deposited. 2) the renal tubules were subject to extensive destruction, whereas the vessels were intact. Continuous urine and blood flow through the transplanted kidneys was seen despite morphological changes and deterioration of renal function.

Animals↗