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Biomedical subjects

S L Yankell

Publications and source records attributed to S L Yankell.

At least 19 recordsLinked to original sources
PubMed1992

Comparative laboratory evaluation of three toothbrushes regarding interproximal access efficacy.

A new toothbrush from the Colgate-Palmolive Company, called the Colgate Precision toothbrush, was compared to the Oral-B 40 toothbrush and Reach Full-Head soft toothbrush using a laboratory device designed to simulate clinical toothbrushing motions and pressures. The toothbrushing time was sixty seconds for each vertical or horizontal brushing motion and for each of the three brushing weights tested, 250, 500 or 750 grams. Interproximal access efficacy was determined by measuring the maximum width of the brushing stroke measured on pressure sensitive paper placed around the simulated anterior or posterior teeth. Twenty-four toothbrushes of each design were evaluated for each toothbrushing motion, tooth shape and toothbrushing weight for a total of 864 measurements. In all studies conducted, the Colgate Precision toothbrush had statistically superior total interproximal access efficacy scores compared to the Oral-B and Reach toothbrushes. In several assessments the Reach toothbrush was superior to the Oral-B 40 toothbrush.

Analysis of Variance↗
PubMed1992

Thirty-day evaluation of the Stimu-gum gingival stimulator and tooth polisher for clinical safety and efficacy.

Two clinical studies have been performed to assess the intraoral safety and efficacy of a mechanical device containing a rubber cup polisher and interdental stimulator (Stimu-gum). In the first study the potential for producing irritation of the oral mucosal tissues was evaluated in 19 subjects when the Stimu-gum product was used in an exaggerated manner, i.e., five times a day for seven days. No untoward effects attributed to use of the Stimu-gum product were observed or reported at anytime in the study. A thirty-day study on 64 subjects compared the Stimu-gum device with an Oral-B 35 manual toothbrush for safety, plaque removal and gingivitis evaluations, at baseline and after 15 and 30 days of product use. The Stimu-gum product and the Oral-B toothbrush were equally effective in removing overnight plaque. The Stimu-gum device was significantly more effective than the Oral-B toothbrush in reducing gingivitis scores at 30 days and bleeding on probing at 15 days. Bleeding on probing scores continued to be lower in the Stimu-gum group at 30 days; however, differences were not statistically significant compared to the Oral-B mean scores.

Adolescent↗
PubMed1992

Rembrandt toothpaste stain prevention with and without the use of Peridex.

Sixty-five subjects were assigned to use Crest or Rembrandt dentifrice with either a placebo or Peridex rinse for eight weeks. One group, using Peridex, started with Crest and switched to Rembrandt at week four of the study. There were no significant differences among the groups on gingivitis, plaque, or calculus by the conclusion of the study. On the stain intensity index there was a significant statistical difference on buccal surfaces between Crest and Rembrandt with placebo compared to Crest with Peridex. On lingual surfaces, Rembrandt with placebo rinse was significantly lower than all Peridex rinse groups by the end of the study. From baseline to the conclusion of the study, Crest with placebo had no change in stain intensity, while Rembrandt with placebo had a significant drop on both buccal and lingual surfaces. The Peridex groups had increases on buccal stain intensity. On stain area scores, by the conclusion of the study both Crest and Rembrandt with placebo were significantly different from Crest with Peridex on buccal and lingual surfaces. Over time there was no significant change in stain area for the Crest with placebo groups. Rembrandt and placebo was significantly lower on stain area from baseline to week eight on buccal surfaces. The Peridex groups had increases in stain area over the study period.

Adolescent↗
PubMed1992

Rembrandt toothpaste: stain removal following the use of Peridex.

Eighteen subjects participated in a stain removal study following two months of Peridex use. The subjects were randomly assigned to use either Rembrandt dentifrice or Crest dentifrice for two months. Indices for stain area and intensity were taken at baseline, two, four, and eight weeks. After eight weeks' use, the Rembrandt group had a 37.1% lower stain area score on facial and 30% lower stain score on lingual surfaces compared to the Crest dentifrice group. On total surface stain area, the Rembrandt group was significantly lower than the Crest dentifrice group at p less than .05. Over eight weeks, the Rembrandt group had a significant drop in stain area while the Crest group had no significant change. On the stain intensity index, there was a 45.7% reduction on facial surfaces and 38.2% on lingual surfaces compared to the Crest dentifrice group which was significant at p less than .01.

Adult↗
PubMed1991

An assessment of Plax pre-brushing dental rinse used according to directions with supervised toothbrushing.

This study assessed the use of a pre-brushing rinse followed with toothbrushing with toothpaste in compliance with label directions. The treatment pre-brushing rinse was compared to a placebo pre-brushing rinse in a cross-over design. The study was started with 20 subjects. One subject developed a throat infection after the first session and was administered an antibiotic prescription and the data was not included in the analyses. No side effects or reactions to the solutions were observed or reported during or following the study. At baseline, the two groups were found to have similar plaque area scores on buccal, lingual, and total tooth surfaces. After rinsing with the pre-brushing solution (Plax) and brushing with an American Dental Association-approved toothbrush and a commercially-available fluoride toothpaste, there was significantly less plaque area when compared to the same regimen with the placebo pre-brushing rinse. For both buccal and lingual plaque area scores the differences were statistically significant at the p less than .05 level favoring Plax. On all surfaces the subjects removed significant amounts of plaque area following rinsing and brushing with toothpaste compared to their baseline scores.

Adolescent↗
PubMed1991

Clinical evaluations on thermal versus mechanical debonding of ceramic brackets.

Removal of ceramic orthodontic brackets, utilizing orthodontic pliers, has resulted in significant patient discomfort, enamel trauma and bracket shattering. The purpose of this clinical study was to compare the safety and efficacy of standard orthodontic mechanical debonding with a new Dentaurum thermal debonding device. Fifteen healthy patients with maxillary or mandibular premolars scheduled for extraction completed this study. One week after bracket placement, removal was accomplished by mechanical pliers or a thermal debonding device. Both procedures were performed on each patient in random order. Efficacy was monitored using scanning electron microscopy (SEM) on impressions made before and at selected times after debonding. Extracted teeth were subjected to histological evaluation to check potential injury to the pulp. Comfort levels were determined by questionnaires. Data was analyzed by Chi square. No irritation or overt changes were reported or observed. Significant differences (p less than 0.05) favoring the thermal devices were determined from the questionnaire on comfort during the removal process. Evaluation of SEM surfaces found significantly less (p less than 0.05) changes produced with the thermal debonding device, compared to mechanical removal. No histological evidence of pulpal injury related to product treatments were determined. The Dentaurum thermal debonding device was judged less traumatic by patients and produced minimal enamel surface changes compared to a mechanical debonding plier.

Adolescent↗
PubMed1991

Clinical evaluation of the Plak Trac toothbrush.

Three separate studies have been conducted to evaluate the clinical safety and efficacy of the Plak Trac mechanical toothbrush. In an exaggerated use study, volunteers used the product a minimum of five times a day for eight days. Soft tissue evaluations were conducted before and at various times after use of the Plak Trac brush throughout the study. No tissue irritation related to product use was observed or reported at any time in the study. In a thirty-day at-home use study the Plak Track brush was compared to the Colgate ADA-approved manual toothbrush. Plak Trac was consistently more effective than the Colgate brush on plaque removal, at higher statistical levels. Both brushes were effective in decreasing the gingival index during the study. In a one-time use test, Plak Trac, Interplak, and the Oral B 35 manual brush were evaluated for plaque removal efficacy. All brushes significantly reduced both smooth surface and interproximal plaque scores. On total smooth surfaces Plak Trac was significantly more effective than the Interplak brush.

Adolescent↗
PubMed1990

Clinical study of a C31G containing mouthrinse: effect on salivary microorganisms.

In vitro studies have demonstrated the antiplaque properties of C31G, a potent broad spectrum antimicrobial agent consisting of an equimolar mixture of alkyl dimethyl glycine and alkyl dimethyl amine oxide, buffered with citric acid. In this initial clinical study, C31G at concentrations of 0.05%, 0.1%, 0.2% and 0.5%. Listerine, and placebo were tested in a complete crossover design. Twelve subjects were evaluated, with a minimum of 2 days between treatments. Parameters monitored were salivary bacterial counts and saliva glycolysis. The 0.5% and 0.2% C31G mouthrinses significantly reduced total bacterial counts in saliva samples obtained up to and including three hours after rinsing, compared with counts obtained prerinsing or after placebo rinsing. Both 0.5%, and 0.2% C31G significantly inhibited glycolysis of salivary bacteria for up to 6 hours postrinsing, compared with pH values obtained prerinsing. 0.1% and 0.05% C31G exhibited little or no effect in either assay. Listerine showed a significant reduction in bacterial counts for up to 1 hour postrinsing, compared with prerinse counts, but the effect was less sustained. Listerine showed no significant inhibition of glycolysis at any time point. No tooth staining or altered taste sensation was noted with either product.

Adult↗
PubMed1989

Clinical study to evaluate the effects of three marketed sugarless chewing gum products on plaque pH, pCa, and swallowing rates.

The purpose of this study was to determine the ability of three commercially available chewing gums (Extra, Trident, and CareFree) to stimulate saliva flow and reverse the plaque acid and ionized calcium levels induced by a glucose challenge. Electrodes to measure pH and pCa were situated in a Hawley appliance. When the Hawley appliance was in place, the electrodes were inserted into three day old plaque at maxillary interproximal sites. A pressure sensor, located in the posterior center of the Hawley appliance, was used to record swallowing rates. After baseline values were determined, the test procedure consisted of first administering a 5% glucose challenge solution followed by a 10 minute challenge effect period, a 5 minute gum chewing or product period, and finally a 10 minute product effect period after the test gum was discarded. An ANOVA was used to compare the ability of each chewing gum to stimulate saliva and cause a return of the plaque acid and/or ionized calcium to baseline levels following product discard. The three chewing gum products varied in both time and level of pH attained while neutralizing plaque acidity (p less than .05) induced by the glucose rinse. No significant differences were found between the chewing gums for the pCa data and swallowing rates. All chewing gum products stimulated swallowing and effectively reversed plaque pH and pCa changes caused by the glucose rinse.

Calcium↗
PubMed1988

C31G, a new agent for oral use with potent antimicrobial and antiadherence properties.

C31G, an equimolar mixture of alkyl dimethyl glycine and alkyl dimethyl amine oxide, was evaluated for antimicrobial and antiadherence properties. The efficacy of C31G, its two components, and several commercial mouth rinses was determined in assays measuring inhibition of glycolysis, inhibition of bacterial adherence, and MICs. Inhibition of glycolysis was determined by using a saliva sediment model, with glycolytic activity expressed as the change in pH relative to that of a control. Adherence studies were undertaken with Streptococcus sobrinus 6715 to measure inhibition of adherence to nichrome wires. MICs were determined against selected microorganisms by standard methods. C31G demonstrated broad-spectrum antimicrobial properties, with activity against both gram-positive and gram-negative organisms and Candida albicans, a yeast. C31G inhibited both glycolysis by salivary bacteria and adherence of Streptococcus strains to wire mesh. C31G was more effective in the assays conducted than any commercial formulation tested and was as effective as chlorhexidine. A synergistic effect was demonstrated between the individual components of C31G, and no loss of activity was noted when it was formulated into a mouth rinse vehicle.

Anti-Bacterial Agents↗