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Biomedical subjects

S L Taylor

Publications and source records attributed to S L Taylor.

138 records · Page 8Linked to original sources
PubMed1973

Liver dehydrogenase levels in rainbow trout, Salmo gairdneri, fed cyclopropenoid fatty acids and aflatoxin B1.

Cyclopropenoid fatty acids in the diet of rainbow trout caused significant reductions in liver protein and activity of glucose-6-phosphate dehydrogenase, NADP-linked isocitrate dehydrogenase, lactate dehydrogenase, and malate dehydrogenase. Changes in total activity were usually accompanied by similar changes in specific activity. The activity of glucose-6-phosphate dehydrogenase appeared to be more sensitive to the ingestion of cyclopropenoid fatty acids than the other dehydrogenases studied. Feeding 20 ppb aflatoxin B(1) to rainbow trout did not significantly change the activity of the dehydrogenases except for a small increase in the activity of glucose-6-phosphate dehydrogenase after 21 days of feeding. Relationships of these changes to the cocarcinogenicity of cyclopropenoid fatty acids and the carcinogenicity of aflatoxin are discussed.

Administration, Oral↗
PubMed1970

New water disinfectant: an insoluble quaternary ammonium resin-triiodide combination that releases bactericide on demand.

Strongly basic anion-exchange resins form stable, water-insoluble combinations with triiodide ions. The combinations have remarkable antibacterial properties: 3.0 x 10(5)Escherichia coli cells per ml were killed when passed through a 3.8-g column of commercially available resin treated with triiodide (volume 4 ml after treatment). In an attempt to deplete the resin-triiodide complex, 1.14 x 10(9)E. coli cells in 15 liters were passed through the column with no significant loss of effectiveness. The antibacterial capabilities of the resin-triiodide columns ranged from 10(6)Salmonella typhimurium per ml to 1.1 x 10(4)Streptococcus faecalis per ml. Staphylococcus aureus and Pseudomonas aeruginosa were also tested and killed at concentrations of 1.8 x 10(4) and 1.3 x 10(5) per ml, respectively. The cells were not filtered from the water. They emerged from the column in nonviable form. This was demonstrated by using (14)C-labeled bacteria. The irreversible nature of the antibacterial action was revealed when attempts to wash the damaged cells did not restore viability.

Bacteria↗
PubMedDate not supplied

Diagnosis of sulfite and aspirin sensitivity.

In addition to the well-recognized allergic responses of individuals to high mol wt substances, such as pollens, molds, and animal dander, susceptible asthmatics may also experience adverse reactions to low mol wt substances such as sulfites, ASA, and NSAIDs. The diagnosis of sulfite and aspirin sensitivity can only be made by appropriately conducted provocative challenge. Every precaution should be taken to assure the safety of the patients, since life-threatening reactions can occur. A better understanding of the mechanism or mechanisms involved in the adverse reactions to these substances will not only provide information to better diagnose the reaction, but also improve our understanding of the treatment of asthma.

Anti-Inflammatory Agents, Non-Steroidal↗
PubMedDate not supplied

Sulphite analysis of food ingredients: false positive responses with butter flavourings in the optimized Monier-Williams method.

The analysis of commercial butter flavouring materials for sulphite by the optimized Monier-Williams method revealed detectable levels of apparent sulphur dioxide (1810 ppm for butter oil, 5760 ppm for butter flavour, and 14.5 ppm for butter derivative) even though the manufacturers claimed that no sulphites were used in processing these ingredients. The presence of volatile fatty acids in these ingredients may explain the anomalous results. Volatile fatty acids were found to interfere with the optimized Monier-Williams method for sulphite determination, detectable levels of titratable acid being found in the hydrogen peroxide trap with amounts of volatile fatty acids as low as 0.3 g. The levels of volatile fatty acids in foods would not be predicted to cause significant interference in the analysis of sulphite residues by the optimized Monier-Williams method. However, this analytical procedure is not recommended for the analysis of sulphite residues in food ingredients containing substantial amounts of volatile fatty acids. Alternative methods for the detection of residual sulphite, such as the sulphite oxidase assay and the colorimetric para-rosaniline method, are not subject to interference by volatile fatty acids.

Butter↗
PubMedDate not supplied

The Gerasim model of caregiving: reflections on Tolstoy's novella, The Death of Ivan Ilyich.

Count Leo Tolstoy's classic novella The Death of Ivan Ilyich (1886/1981) is examined from the perspective of a health care professional for its portrayal of a helping relationship between the central character and his servant Gerasim. The purpose of the article is to extrapolate helping behaviors depicted in the story and construct a caregiving model. Tolstoy's work, literary critiques of the novel, biographies of Tolstoy, and principles from feminist ethics are used as sources. The model will be of assistance to those who care for the terminally ill.

Caregivers↗
PubMedDate not supplied

Quandary at the crossroads: paternalism versus advocacy surrounding end-of-treatment decisions.

The moral and ethical basis for promoting the patient as ultimate decision-maker regarding his or her treatment plan is advanced. The practice implications of differing educational and historical backgrounds of physicians and nurses is addressed. Paternalism and maternalism are examined. These traditional roles are contrasted with the emerging provider role as patient advocate. Recommendations are suggested for improved physician/ nurse/patient interaction in the resolution of ethical dilemmas in a highly complex health care arena.

Attitude of Health Personnel↗
PubMedDate not supplied

Peanut sensitivity.

Peanuts are one of the most allergenic foods. The allergic reactions may vary in severity from mild urticaria to severe anaphylactic episodes and death. The prevalence of peanut sensitivity is unknown, but it may affect as many as 10% of allergic individuals. The chemistry of peanut proteins has been extensively studied. Two major protein fractions have been prepared from saline extracts of peanut flour, arachin and conarachin. A major peanut allergen termed "Peanut-1" has been isolated. However, a number of protein constituents, including the arachin and conarachin fractions, have been shown to be allergenic. The ability to diagnose peanut sensitivity accurately has been hampered by the lack of standardized peanut extracts. However, efforts are under way to prepare such standardized reagents. Treatment consists of avoiding peanut protein products and using self-administered epinephrine. A number of peanut protein-containing products are allergenic, although peanut oil is not. The peanut-allergic consumer should be instructed to carefully read labels of foods. This can at times, however, be misleading, because certain foods may be inadvertently contaminated by peanut proteins.

Allergens↗
PubMedDate not supplied

Avoidance diets--how selective should we be?

Selective avoidance diets are the most common means of treatment for food allergies and other types of food sensitivities. With IgE-mediated food allergies, adverse reactions can occur in some patients to very small amounts of the offending food; therefore, strict avoidance of the offending food must be accomplished. With other, non-immunological types of food sensitivities, such as lactose intolerance and sulfite sensitivity, the patients are able to tolerate some, although variable, amounts of the offending substance. Thus, the degree of tolerance is an important concern in the construction of safe and effective avoidance diets. Another issue in the development of selective avoidance diets is the presence of the allergen in specific foods. For example, the peanut allergen is a protein which is not present in peanut oil. Consequently, peanut oil is safe to consume for peanut-allergic patients. Cross-reactivity is yet another concern in the development of selective avoidance diets. Cross reactions can occur between related species of legumes, crustacea, eggs, and milk for example. The construction of a safe and effective avoidance diet for food allergies and sensitivities requires consideration of several important issues and is a responsibility that should not be taken lightly.

Cross Reactions↗