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Biomedical subjects

S L Gordon

Publications and source records attributed to S L Gordon.

At least 37 records · Page 2Linked to original sources
PubMed1985

Assessment of bone grafts used for acetabular augmentation in total hip arthroplasty. A study using roentgenograms and bone scintigraphy.

Total hip arthroplasty was performed in 13 hips with acetabular bone grafts for secure component fixation. The incorporation and healing of acetabular bone grafts were investigated with the aid of roentgenograms, planar bone scans, and a newer scintigraphic technique, three-dimensional single photon emission computed tomography (SPECT). Conventional roentgenograms proved unreliable in evaluating bone graft reconstitution because of overlapping trabecular bone patterns of the graft and iliac wing. There was no evidence of graft failure or acetabular loosening. Bone grafts in the late follow-up group (four to seven years postoperation) exhibited normal radionuclide activity, whereas grafts less than one year postsurgery demonstrated patterns of increased activity. SPECT was helpful in producing an anatomic reconstruction of the acetabulum. The observation that bone grafts exhibited normal biological viability is crucial for ensuring secure acetabular component fixation on a long-term basis.

Acetabulum↗
PubMed1984

Solvent proton magnetic resonance dispersion in protocatechuate 3,4-dioxygenase and complexes with 3-halo-4-hydroxybenzoate inhibitors.

Solvent proton nuclear magnetic dispersion studies at 25, 100, and 300 MHz have been performed on protocatechuate 3,4-dioxygenase (PCD) and its complexes with 3-chloro-4-hydroxybenzoate and 3-fluoro-4-hydroxybenzoate. Longitudinal and transverse relaxation rates were measured for these compounds and for the apoenzyme. The paramagnetic enhancement of solvent T1 is interpreted in terms of dominant dipole-dipole relaxation of fast-exchanging solvent protons with a negligible contribution from outer sphere relaxation and an electronic spin relaxation time of 0.5 ns for the high-spin ferric ion. A discrepancy between the observed T2 at 300 MHz and that calculated by assuming the usual dipolar relaxation provides evidence for an additional Curie-spin dipolar or hyperfine interaction between the proton and iron. Quantitation of the additional relaxivity provides an estimated chemical exchange lifetime of 0.1-0.14 microseconds, which suggests proton exchange by a hydroxide ligand. Proton-to-iron distances are 2.7-3.1 A in PCD and lengthen to 3.6-4.1 A in the halohydroxybenzoate complexes.

Apoenzymes↗
PubMed1981

Hereditary multiple exostoses: report of a kindred.

In a large family with 37 members with multiple exostoses, only one person has developed sarcomatous degeneration of a lesion. Our review of published reports revealed great variation in the incidence of malignancy in multiple exostoses (10 to 25%). Most studies had sampling errors leading to the apparent overstatement of risk. In large pedigrees with essentially complete ascertainment of affected subjects, the risk of malignancy is nearer 3% or less. This lower risk for malignancy may be more appropriate in counselling affected subjects.

Adolescent↗
PubMed1980

Gas gangrene in a wound treated without skin closure: a case report.

Clostridial myonecrosis developed in a compound tibial fracture wound left open after extensive surgical debridement. The patient survived after having a below-knee amputation and postoperative erythromycin. Prophylactically administered cephalothin failed to prevent the clostridial infection.

Adult↗
PubMed1979

NADPH cytochrome P-450 reductase activation of quinone anticancer agents to free radicals.

With NADPH as the electron donor, rat liver NADPH cytochrome P-450 reductase (NADPH:ferricytochrome oxidoreductase, EC 1.6.2.4) catalyzes the single-electron reduction of several quinone antibiotics to a semiquinone or free radical state. The benzanthraquinones adriamycin, daunorubicin, carminomycin, 7-O-methylnogalarol, and aclacinomycin A and the N-heterocyclic quinones streptonigrin and mitomycin C are activated to free radical intermediates which can transfer their single electron to molecular oxygen to form superoxide. The overall Km range for this electron transfer is 0.4 to 42.1 X 10(-4) M. We postulate that the formation of the "site-specific free radical/ intermediate is central to the cytotoxic action of these antibiotics.

Animals↗
PubMed1978

Power take-off injuries.

Power take-off injuries are uncommon, but serious and potentially fatal. Seven cases are reported demonstrating the violent trauma that can be incurred. The danger associated with use of machines with this and other power equipment is emphasized. Safety shields should be improved, and operators educated about the importance of retaining the shields and using machinery properly at all times.

Accidents, Occupational↗
PubMed1978

Craniosynostosis associated with limb reduction malformations and cleft lip/palate: a distinct syndrome.

Craniosynostosis associated with short stature, radial and fibular aplasia, and cleft lip and/or palate represents a distinct syndrome. One original case and one previously undiagnosed case from the literature were found to have many distinct features in common, permitting them to be separated from craniosynostosis with radial or fibular aplasia, Robert's syndrome, pseudothalidomide or SC syndrome, and the hypomelia-hypotrichosis-facial hemangioma syndrome. Each had multiple craniofacial abnormalities: dysplastic ears, hypertelorism, strabismus, and malocclusion. Ulnae and humeri were hypoplastic; tibiae were bowed and hypoplastic. Testes were small. Associated mild to moderate mental retardation may be related to early institutionalization.

Abnormalities, Multiple↗
PubMed1977

Acessory nerve function after surgical procedures in the posterior triangle.

Seventeen patients who had undergone surgical procedures in the posterior triangle of the neck were examined between one day and four years after operation. Eleven patients were studied with electromyography. Clinical and electromyographic evidence of 11th cranial nerve paresis was present in 12 patients. Partial nerve injuries and entrapments, as suggested by delayed symptoms and incomplete denervation on electromyographic studies, were frequent. Physiotherapy was effective in restoring a satisfactory, although in many cases an incomplete, return of function. The spinal accessory nerve appears to be vulnerable to injury despite careful preservation during surgical dissection.

Accessory Nerve↗
PubMed1977

Radiological quiz. Familial hyperphosphatasemia.

Hyperphosphatasemia is a genetic disorder of intramembranous bone formation which is radiographically similar to Paget's disease. The authors report a case of hyperphosphatasemia complicated by salt-losing congenital adrenal hyperplasia in a Puerto Rican child. Recognition of this condition is important because of the promising results with calcitonin therapy.

Adrenocortical Hyperfunction↗
PubMed1977

Residua of Guillain-Barré Polyneuritis in Children.

A study of the records from the period 1950 to 1970 at the Elizabethtown Hospital for Children and Youth produced twelve patients with the Guillain-Barré syndrome. These patients were contracted in 1975-76 and each was personally examined. Ten were found to have residual weakness but in several instances the weakness was so mild the patient was unaware of it. Good correlations were found between muscle examinations during the acute recovery period and at final follow-up. Six patients had undergone various surgical procedures, and all of them thought they had benefited.

Adolescent↗
PubMed1977

Multiple joint infections with Enterobacter cloacae.

An infant with multiple joint infections from Enterobacter cloacae seems not to have been reported previously. The infant survived, incurred a pathologic dislocation of the left hip, but at 18 months of age was well with all other joints functioning normally.

Ankle Joint↗
PubMed1976

Intramolecular 1H nuclear Overhauser effect study of the solution conformation of valinomycin in dimethyl sulfoxide.

Determination of the mechanism of intramolecular nuclear Overhauser effects (NOE) in peptides and depsipeptides is essential to the use of this technique in conformational analysis of these and related biomolecules. Towards this end, 1H NMR double-resonance studies were conducted on valinomycin in (CD3)2SO at 90 MGZ (FT mode) and 250 MGZ (correlation mode). The NOE's are positive at the lower frequency and negative at the higher frequency. Consideration of the theoretical dependence of the NOE on the proton-proton internuclear correlation time and on the resonance frequency indicates that these results are explained by a predominantly dipolar relaxation mechanism. It is demonstrated that exchange modulation of scalar coupling does not contribute significantly to the NOE. A formalism for the NOE's of loosely coupled spin systems is presented which takes into account the effects of high magnetic-field strengths and long correlation times. An approximate analysis of the NOE data assuming a single correlation time for the entire molecule and ignoring cross-relaxation effects was used to evaluate various models that have been proposed for the conformation of valinomycin. The III-1 model of Patel and Tonelli (Patel, D.J., and Tonelli, A.E. (1973), Biochemistry 12, 486) fits the NOE and peptide NHCalphaH coupling constant data and is probably a preferred orientation in dimethyl sulfoxide. These experiments illustrate how intramolecular NOE data provide a valuable auxiliary method to other techniques for delineating the preferred solution conformation of peptides, depsipeptides, and other biomolecules.

Binding Sites↗
PubMed1976

Lateral collateral ligament ankle injuries in young athletic individuals.

1. Eleven cases of surgical repair of acute tears of the capsule, anterior talo-fibular, and calcaneo-fibular ligaments of the ankle in young athletic individuals are reported. 2. Diagnosis was made by clinical examination and stress X-rays and confirmed by arthrography in selected cases. All of the ligament ruptures were visualized at surgery. 3. Post-surgery, all of the patients had a stable ankle and were able to return to vigorous athletic endeavors without disability. 4. This study lends support to the impression that surgical repair of severe lateral collateral ankle ligament injuries in young athletic individuals leads to a functionally and mechanically stable ankle able to withstand severe stress without disability.

Adolescent↗
PubMed1976

Injuries from rotary power lawnmowers.

Injuries from power lawnmowers most frequently involve the toes or the foot. The most common injury is caused by an extremity being caught in the moving parts of the machine. The greatest injury is to the skin and soft tissue by degloving or avulsion. Most of these injuries, especially those which occur to children who are passengers on self-propelled mowers, are preventable by observance of simple precautions.

Accidents, Home↗