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Biomedical subjects

S L Fischman

Publications and source records attributed to S L Fischman.

At least 19 recordsLinked to original sources

The motivational benefits of a dentifrice containing baking soda and hydrogen peroxide.

Twenty-two family practice dentists, in a large metropolitan area, were recruited to act as independent examiners in a study to evaluate the compliance of their patients to accept a good oral hygiene regimen with the use of a fluoride dentifrice, containing hydrogen peroxide and baking soda, dispensed from a dual dispensing package. To evaluate compliance, the dentists attended an orientation seminar and were trained to assess gingival health using the CPITN periodontal probe. Each dentist evaluated the gingival health status of five to seven of his own patients, initially and after one and three months of product use following hygiene instruction and product assignment. One-hundred and thirty-one patients successfully completed the study. After one month of using the hydrogen peroxide/baking soda toothpaste, the mean reduction in bleeding sites was 53%; at three months the reduction was 62%. The hydrogen peroxide/baking soda dentifrice was well accepted by dentist and patient, and a discernible improvement in oral health of the patients was achieved when the product was used in a conscientious oral hygiene program.

Adult

The laboratory and clinical safety evaluation of a dentifrice containing hydrogen peroxide and baking soda.

This study reports the laboratory, clinical, and microbiological finding of the safety testing and daily use of a dentifrice delivering 0.75% hydrogen peroxide and 5% baking soda. Laboratory studies using Ca45 labeled teeth and biologically stained teeth confirmed that the dentifrice did not decalcify enamel or bleach teeth. Over the course of a six-month period, 62 subjects using a hydrogen peroxide-baking soda dentifrice and 21 subjects using a control dentifrice were examined for oral soft tissue change and hard tissue alterations. No soft tissue changes attributable to the use of either dentifrice were noted. Experienced clinicians using Trubyte shade guide teeth observed no significant changes to the subjects' anterior teeth following 6 months use of the test dentifrice. Paired discrimination tests revealed that the examiners could distinguish color differences in the shade guide teeth at 0.7%. Microbiological monitoring of the subjects for six months use of their assigned dentifrice and for the following months on the control dentifrice, revealed neither an increased incidence of candida nor increased candida counts.

Adult

Dental specialty education.

Dental education has been the topic of considerable discussion in the dental literature during the period between February 1990 and January 1991. Emphasis has been given to the current financial and pedagogic problems facing the profession. It is a time of change, perhaps even great change, and this review focuses on those articles most significant for specialty education at the predoctoral and postdoctoral levels.

Education, Dental

Controversies in oral medicine.

This article reviews two conditions commonly seen in oral medical practice. Aphthous ulceration and lichen planus are two very perplexing problems with controversies about etiology, pathogenesis, diagnosis, management, and, in the case of lichen planus, malignant potential.

Administration, Topical

Clinical index systems used to assess the efficacy of mouthrinses on plaque and gingivitis.

The American Dental Association's Council on Dental Therapeutics has adopted Guidelines for acceptance of chemotherapeutic products for the control of supragingival dental plaque and gingivitis. The most widely used plaque indices are the plaque index (PI) and the Turesky index. Gingivitis has usually been assessed by the Löe and Silness method, although the modified gingival index of Lobene and a bleeding index reported by Caton and Polson have also been used. To date, 2 products have been accepted by the Council as being effective in helping control supragingival plaque and gingivitis. These products were evaluated using clinical indices described in this review. The indices were selected from the many in the literature as being valid, reliable, and easily learned. Suggestions are made for criteria to be used in comparability studies.

Dental Health Surveys

Role of the general practitioner in data collection and cross matching.

Dental records used in identification procedures are most often obtained from the offices of general practitioners. The family dentist is required to provide accurate and well documented data to assist in the identification process. The forensic team participating in a mass disaster identification may also utilize the services of general practitioners. They play an active role in the oral autopsy, the oral radiographic procedure, and the identification process itself.

Data Collection

Current status of indices of plaque.

Microbial plaque has been described by the Council on Dental Therapeutics of the American Dental Association in their recently drafted Guidelines for acceptance of products for the management of dental plaque and gingivitis. The choice of an index system to be used in plaque trials should be made in terms of the objective of the trial, the size of the population, the period of the study, and the type and extent of change anticipated. The indices currently in use estimate the quantity of plaque in terms of tooth area covered or the thickness of material in the area measured. The Silness and Loe and the modified Turesky methods have been suggested as acceptable indices for the estimation of cleansing ability.

Dental Health Surveys

The use of medical and dental radiographs in identification.

Following mass disasters and individual deaths, dentists with special training and experience in forensic odontology are frequently called upon to assist in the identification of badly mutilated or decomposed bodies. Teeth and dental restorations are resistant to destruction by fire and the elements and are, therefore, useful in identification. The forensic odontologist makes use of dental radiographs taken of the victim before death. These are compared to dental data from the remains to assist in making the identification. Many features of the teeth and numerous characteristics of dental treatment are quite unique. This permits accurate and legally acceptable identification of the remains. The cases described illustrate the procedures and techniques of identification using ante-mortem and post-mortem radiographs.

Adult

Inter-examiner reliability in caries trials.

A statistical model is given for representing the several components of variability present in measurements (e.g., DMFS scores) given by examiners to patients. Methods for making inferences about the intraclass correlation coefficient of reliability are presented and illustrated on a real set of data. The proper analysis of data from a reliability study is shown to depend on the planned design and analysis of the clinical or field trial to be conducted following the reliability trial.

Child

Design of studies to evaluate plaque control agents.

The importance of plaque in the etiology of periodontal diseases is reviewed. A survey is also presented of the various indices for scoring plaque in clinical trials. Variations in the clinical design, type of population studied, and difficulty in scoring gingival plaque are reviewed. A survey is presented of some recent published studies of plaque-inhibiting agents.

Anti-Bacterial Agents

In vitro antiplaque properties of a series of alkyl bis(biguanides).

A series of eight alkyl bis(biguanide) analogues of alexidine, N,N''''-1,6-hexanediyl bis[N'-(2-ethylhexyl)imidodicarbonimidic diamide] (1), was prepared. Five of these analogues constituted a series isolipophilic with 1 but with varying bridge length between biguanide moieties. The compounds were evaluated in vitro for antibacterial and antiplaque properties against Streptococcus mutans, Actinomyces viscosus, and Actinomyces naesludii. One analogue, N N,''''-1,6-hexanediyl bis[N'(n-octyl)imidodicarbonimidic diamide], appeared to be more effective than either 1 or chlorhexidine against this spectrum of dental plaque forming microorganisms.

Actinomyces

Randomized, double-blind study of levamisole in recurrent aphthous stomatitis.

A randomized double-blind study was designed to evaluate the safety and efficacy of levamisole in the treatment of recurrent aphthous stomatitis (RAS). Thirty patients, aged 9-65 years, were selected, based on a documented history of three or more episodes of RAS. Patients were instructed to take 150 mg of levamisole (or placebo) daily for 3 days at the onset of the first prodromal symptoms of an ulcer. The regimen was to be repeated for each new episode, but not more than once per week. At each episode patients were examined and evaluated as to number and duration of ulcers, interval between episodes, pain associated with ulcers, and side effects. Data on 24 patients were suitable for analysis. Of those patients receiving levamisole, six showed slight improvement and five were unchanged. Of those patients receiving the placebo, one showed a marked improvement, four slight improvement, six were unchanged, and two deteriorated. There was neither a clinical nor a statistically significant difference between the groups. It is concluded that levamisole, in this study protocol, had no effect on the incidence or severity of aphthous ulcers.

Adolescent

Oral cancer in Puerto Rico.

All cancer cases diagnosed in Puerto Rico are analyzed and registered in the Central Cancer Registry. The incidence of oral cancer in Puerto Rico is fourth-highest in the world. (In 1972 oral cancer accounted 72% of all cancers in males in Puerto Rico.) A review of the data revealed important contrasts with reported statistics from the continental United States (e.g., 75.6% of the cases in Puerto Rico were initially treated by radiation, compared with 15.3% of the cases in Western New York States.

Age Factors

Histopathologic, ultrastructural, and immunologic findings in an oral psoriatic lesion.

There has been some controversy over whether psoriasis can involve the oral mucosa. An oral lesion in a 32-year-old man with a psoriatic scalp lesion has been studied by light and electron microscopy and by immunologic methods. Results from each of these three techniques are consistent with previous findings in psoriatic lesions and suggest that oral psoriasis can occur.

Adult