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Biomedical subjects

S L Fine

Publications and source records attributed to S L Fine.

At least 127 records · Page 7Linked to original sources
PubMed1980

Central serous retinopathy in a 7-year-old girl.

A 7-year-old girl experienced sudden loss of central visual acuity in one eye. Ophthalmoscopy disclosed a serous detachment of the sensory retina, and fluorescein angiography showed many areas of focal dye leakage through the pigment epithelium. Visual acuity returned to 6/7.5 (20/25), and the subretinal fluid was reabsorbed completely over the next two months. To our knowledge, this is the youngest patient with central serous retinopathy ever described.

Age Factors↗
PubMed1980

Optic disc neovascularisation in diabetic retinopathy: I. A system for grading proliferation at the optic nerve head in patients with proliferative diabetic retinopathy.

An anatomical taxonomy for neovascular proliferation of the optic nerve head in patients with proliferative diabetic retinopathy is presented. The technique consists in comparing (A) number of involved quadrants, (B) calibre of vessels, (C) neovascular density, (D) neovascular area, (E) plane of proliferation, and (F) fluorescein angiographic findings. A similar taxonomy is used to describe fibrous tissue proliferation at the disc. With these criteria a series of standard photographs have been utilised in a numerical grading system. This system has proved useful in documenting the natural history and response to photocoagulation therapy for diabetic disc neovascularisation.

Diabetic Retinopathy↗
PubMed1980

Optic disc neovascularisation in diabetic retinopathy: II. Natural history and results of photocoagulation treatment.

A follow-up study on 67 diabetic patients with new proliferation on the nerve head (neovascularisation of the disc and fibrous proliferation of the disc) was carried out for 4 years. The patients were randomly assigned for treatment with argon laser and xenon photocoagulation in only one eye, with the other eye serving as a control. The disc condition was periodically evaluated for NVD, FPD, and for the relations between them according to a grading taxonomy which was previously established. It was found that there were significant differences in NVD and FPD evolution between treated and untreated eyes. The various parameters concerned with these differences were observed, analysed, and correlated.

Adolescent↗
PubMed1980

Follow-up study of detachment of the retinal pigment epithelium.

To determine the clinical course of untreated retinal pigment epithelial detachment we reviewed data from 50 eyes of 42 patients followed up for an average of 29 months without photocoagulation. In 14 eyes with avascular lesions, in patients under 50 years of age, all had a final vision of 20/30 or better. None developed neovascularisation or haemorrhage. In 17 eyes with avascular lesions in patients aged over 50, 8 (47%) flattened spontaneously. Five (24%) developed neovascularisation, 2 of which became haemorrhagic, with vision of less than 20/200. In 19 senile eyes with vascular lesions 14 (74%) had a final vision of 20/200 or less. The prognosis in eyes with pigment epithelial detachments is related to the age of the patient and the presence of choroidal neovascularisation. Photocoagulation is seldom needed for pigment epithelial detachments in young patients. Its value in senile eyes is unproved.

Adult↗
PubMed1978

Results of argon laser photocoagulation in presumed ocular histoplasmosis.

We performed argon laser photocoagulation on 31 eyes of 30 patients with presumed ocular histoplasmosis. Nineteen of 25 eyes (76%) with neovascular membranes 0.25 disk diameter or further from the fovea had 6/12 (20/40) or better vision after an average follow-up period of 20 months. Twenty-two of these eyes (88%) had the same or improved visual acuity during this period. When compared to a similar group of untreated eyes, the apparent advantage of photocoagulation in preserving visual acuity was not statistically significant.

Argon↗
PubMed1977

Flicker fusion thresholds in Best macular dystrophy.

Flicker fusion threshold intensities were measured as a function of flicker frequency for patients with Best macular dystrophy having normal or near-normal Snellen visual acuity. These data were found to differ from normal in ways that may be interpreted to be an abnormal elevation of the foveal cone threshold, a loss of cone temporal resolution, or both. The results led to the conclusion that Best macular dystrophy affects the neurosensory retina even when Snellen visual acuity is normal.

Flicker Fusion↗
PubMed1977

Congenital retinal arterial loops and vitreous hemorrhage.

In two adolescents, mild vitreous hemorrhage occurred from the area of retinal arterial loops near the optic nerve. In both cases the hemorrhage cleared without further complications. This vascular malformation may be associated with secondary complications more frequently than has previously been reported.

Adolescent↗
PubMed1977

Follow-up study in eyes with choroidal neovascularization caused by presumed ocular histoplasmosis.

Sixty-four eyes of 60 patients with ocular histoplasmosis, and choroidal neovascularization documented by fluorescein angiography, and not treated with photocoagulation, were followed for an average of 29 months. The primary determinant of visual outcome was the proximity of the neovascular membrane to the fovea. Sixty-four percent of eyes with membranes 0.25 disk diameter or greater from the fovea had a final visual acuity of 6/12 (20/40) or better, and 71% of such eyes maintained or improved initial visual acuity. All eyes with subfoveal neovascularization had a poor visual result. Other factors related to visual prognosis included initial visual acuity, size of the neovascular membrane, size of sensory retinal detachment, and presence of hemorrhage.

Adolescent↗
PubMed1977

Eales' disease.

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Adult↗
PubMed1977

Angioid streaks.

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Adult↗
PubMed1976

Subretinal neovascularization developing after prophylactic argon laser photocoagulation of atrophic macular scars.

Two patients who had lost central vision in one eye due to a histoplasmic disciform macular scar received prophylactic argon laser photocoagulation to one or more atrophic lesions (histo spots) in the second macula in an effort to reduce the risk of developing active neovascularization in the second eye. Despite this prophylactic treatment, both patients developed a choroidal neovascular membrane from the photocoagulation scar.

Adult↗
PubMed1976

Perifoveal vascular leakage and macular oedema after intracapsular cataract extraction.

Perifoveal capillary leakage of fluorescein was demonstrated in 60 per cent of 50 eyes when angiography was performed two weeks after cataract extraction. Repeat angiography six weeks postoperatively in 17 eyes demonstrated persistence of already established leakage in 11 of 12 eyes and no new leakage in five eyes previously negative. Cystoid macular oedema with visual acuity of less than 20/40 six weeks postoperatively occurred in five eyes (10 per cent). Eyes of patients with vascular disease and those patients of 60 years or older were found to have altered vascular permeability significantly more frequently. Inflammation was no more severe or prevalent in those patients who demonstrated leakage and no inflammation was clinically apparent in 10 of 11 eyes demonstrating dye leakage six weeks postoperatively. We conclude that the constitutional factors of age and vascular disease are of prime importance in causing altered vascular permeability in the early postoperative period after cataract extraction; factors causing sustained leakage with reduction of visual acuity were not demonstrated.

Adult↗
PubMed1976

Diabetic macular edema.

Photocoagulation by either the argon laser or xenon arc instruments has been reported to have a beneficial effect in selected patients with macular edema. Treatment is not effective in all cases; indeed, in some patients with perifoveal capillary closure, severe macular edema, long-standing organized hard exudates, or significant cystoid maculopathy, treatment has proved to be ineffective. Findings associated with a generally favorable or an unfavorable prognosis following photocoagulation are discussed in this chapter, along with proper management of the patient's systemic status, with particular emphasis on the problem of hypertension, important in patients with diabetic macular edema. Because the results of photocoagulation are limited in a significant number of patients, further research into the basic pathogenetic mechanisms involved in increased retinal capillary permeability to recommended, with the hope of providing more effective therapy.

Adult↗
PubMed1976

Argon laser photocoagulation in ocular histoplasmosis syndrome.

Argon laser photocoagulation was performed on 30 patients with ocular histoplasmosis syndrome involving the macula. Selection of patients for photocoagulation was dependent upon locating the sub-retinal neovascularization (SRNV) at least one vein-width removed from the capillary-free zone of the fovea on fluorescein angiography. Of the 30 treated patients, 27 maintained or improved visual acuity an average of 1 1/2 years following photocoagulation.

Adult↗
PubMed1975

Comparison of xenon arc and argon laser photocoagulation in ocular histoplasmosis.

Argon laser and xenon arc photocoagulation can be utilized to obliterate choroidal neovascularization in selected cases of macular histoplasmosis. Central vision can be preserved in many instances if criteria for patient selection, treatment techniques, and method of follow-up, as described in this chapter, are adhered to rigidly. Of 40 patients treated with argon laser photocoagulation, 75 percent maintained or improved central vision an average of one year following treatment. Nonetheless, there is a definite need for a prospective controlled study to document the efficacy of this mode of treatment on a long-term basis.

Adult↗