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Biomedical subjects

S Kurihara

Publications and source records attributed to S Kurihara.

At least 199 records · Page 11Linked to original sources
PubMed1981

Dysplasia during pregnancy: a cytologic follow-up study.

To clarify the characteristics of dysplasia in the pregnant state, 525 of 703 dysplasias in pregnant women recorded in the laboratory computer at the University of Chicago Lying-in Hospital during a ten-year period were selected for study through medical records. These materials were basically diagnosed by cytologic techniques. The regression rates of moderate and marked dysplasia within a six-month period after delivery seemed to be much higher than those of dysplasia in the general population. The progression rates of dysplasia to carcinoma in situ during pregnancy and after delivery were almost the same as those of dysplasia in the nonpregnant state, whereas the progression rate of dysplasia to invasive carcinoma after delivery (0.4%) was almost half that in the nonpregnant state (1%). With reference to the latent period during which dysplasia progressed to malignancy, dysplastic lesions during pregnancy, as compared to those in nongravid women, had a higher potential for progression. The number of dysplastic cells decreased with the course of pregnancy. The rates of metaplastic and keratinizing types of dysplasia were remarkably higher than those in the general population, and the rates of those types of dysplasias increased with the course of pregnancy.

Adolescent↗
PubMed1980

An electron microscopic study of attachments between periodontal fibers and bone during alveolar remodeling.

Three types of periodontal membrane-to-bone attachments are described for remodeling surfaces of the bony alveolar wall. An adhesive type, which is the most widespread means for tooth anchorage on resorptive bone surfaces during active tooth movements, involves the following histogenic steps: A layer of ground substance is first deposited by fibroblast-like cells on the naked surface of recently resorbed bone. As this continues, new precollagen and the dissociated ends of collagenous fibrils become embedded in the accumulating ground substance, and these fibrils in turn become joined to intact collagenous fibrils, blending with the remainder of the periodontal stroma. Such adhesive attachments continuously form and re-form as the resorption front proceeds. A continuous type of attachment also occurs on resorptive bone surfaces in which some (not all) bone matrix fibrils survive the resorptive process. These former bone fibrils become incorporated into the periodontal membrane and are continuous between the bone matrix and the stroma of the contiguous periodontal membrane. An intermediate type of attachment also occurs and is primarily an adhesive attachment that also contains a scattering of fibrils which are continuous from the bone matrix across the resorptive bone surface into the fibrous matrix of the periodontal membrane.

Alveolar Process↗
PubMed1980

A histochemical and electron microscopic study of an adhesive type of collagen attachment on resorptive surfaces of alveolar bone.

This study describes (1) the composition of the "adhesive" type of periodontal membrane attachment onto resorptive surfaces of actively remodeling alveolar bone; (2) the structure of reversal lines in alveolar bone; and (3) the role of certain fibroblast-like "osteoclast companion cells" in the attachment process of periodontal fibers onto resorptive bone surfaces. Adesive attachments involve a layering of specific zones at the interface between the periodontal membrane and the resorptive bone surface, and one or more types of osteoclast companion cells appear to function in the secretion of components of proteoglycans (probably glycosaminoglycans) and precollagenous fibrils. The proteoglycans appear to serve as a principal component of the adhesive substance secreted on a bone surface and also as a binding agent for the linking and progressive relinking of new and old collagenous fibers to each other and to the resorbed bone surface. If a reversal in the direction of remodeling occurs, and new bone deposition occurs on a surface that was formerly resorptive, the zones of the adhesive interface become calcified and then constitute a "reversal line."

Alveolar Process↗
PubMed1980

Serum ferritin levels in patients with cervical cancer.

Serum ferritin levels were determined by a radioimmunoassay (a 2-site solid-phase method). The mean ferritin level for 52 control women was 35 ng/ml, and the 2nd to 98th percentile reference intervals were 3.9 to 108 ng/ml. The upper limit of ferritin level for controls was determined to be 108 ng/ml, and the sera from cervical cancer patients were screened. In 98 patients with untreated cervical cancer, 50 (51%) had elevated levels of serum ferritin. Among 36 patients who were surgically treated and whose resected specimens were pathologically examined, 12 of 16 patients (75%) with ferritin levels above normal and 3 of 20 patients (15%) with levels below 108 ng/ml had parametrial invasion and/or lymph node metastasis. Serum ferritin levels were measured at 2- to 4-week intervals and 6 months after treatment on 21 patients with levels elevated before therapy. Ferritin levels decreased to the normal range 4 weeks after treatment in many patients, but the development of elevated levels thereafter was closely associated with a poor prognosis. Measurement of serum ferritin may be useful in predicting the extent of cancer beyond the cervix and the prognosis for cervical cancer patients.

Adult↗
PubMed1980

Binding of bullous pemphigoid antibodies to basal cells.

Eight out of 12 serum samples from patients with bullous pemphigoid having basement membrane zone antibodies gave positive binding not only to the basement membrane zone but also to the basal cell membrane and/or cytoplasm as observed by complement immunofluorescence. Reaction of fluorescein labeled pemphigus vulgaris gamma-globulins, binding mainly to the lower intercellular spaces of the epidermis, was greatly reduced by the prior incubation of high-titered bullous pemphigoid sera having the reactivity to the basal cells, while that of fluorescein labeled pemphigus foliaceus gamma-globulins binding mainly to the upper and middle intercellular spaces, was not influenced by the prior application of these bullous pemphigoid sera. These results indicate that bullous pemphigoid antibodies are heterogenous and can be classified into 2 types and that some cross reaction is present between pemphigus antibodies and bullous pemphigoid antibodies having the reactivity to the basal cells.

Antigen-Antibody Reactions↗