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Biomedical subjects

S Koga

Publications and source records attributed to S Koga.

At least 433 records · Page 24Linked to original sources
PubMed1981

Prognostic significance of combined splenectomy or pancreaticosplenectomy in total and proximal gastrectomy for gastric cancer.

The prognostic significance of combined splenectomy or pancreaticosplenectomy in total and proximal gastrectomy for gastric cancer was evaluated from the viewpoints of lymph node metastasis in the splenopancreatic region and postoperative long-term survival. The postoperative long-term results were not improved in patients who had undergone combined resection, indicating that the course after total or proximal gastrectomy for advanced gastric cancer is more affected by serosal invasion than lymph node metastasis in the splenopancreatic region. Therefore, combined resection may be of prognostic significance in patients with gastric cancer manifesting lymph node metastasis in the splenopancreatic region but not serosal invasion.

Evaluation Studies as Topic↗
PubMed1981

Serum apoprotein A-I and A-II levels in liver diseases and cholestasis.

Serum apoprotein A-I and A-II levels were determined by electroimmunoassay in patients with liver diseases and cholestasis. Significant decreases in apoprotein A-I and A-II levels were observed in such patients. The decreases were especially pronounced in the early phase of acute hepatitis and cholestasis. The decreases in A-II levels were more prominent than the decreases in A-I in severe hepatic dysfunction or cholestasis. Accordingly, the A-I/A-II ratio showed no change in the convalescent phase of acute hepatitis or chronic hepatitis but increased significantly in the early phase of acute hepatitis, cirrhosis of the liver, hepatoma, and cholestasis. The results suggested the existence of a high density lipoprotein with an abnormal apoprotein composition or a more profound decrease of HDL3 than of HDL2 in severe hepatocellular dysfunction of cholestasis.

Adult↗
PubMed1981

Morphogenesis of peritoneal metastasis in human gastric cancer.

A comparative light microscopic and scanning electron microscopic study of the morphogenesis of peritoneal metastasis in 34 human gastric cancers was performed. Prior to adhesion of gastric cancer cells to the peritoneum, the mesothelial cells became hemispherical and exfoliated from the peritoneum, and gastric cancer cells adhered to the naked areas of the submesothelial connective tissue. A flat metastatic tumor was formed by cancer cell proliferation in the shallow region of the peritoneum. Subsequently, after the infiltration of cancer cells into the connective and adipose tissue, the formation of a large tumor mass was observed. There was a correlation between the surface and histological structure of the metastatic tumors. In poorly differentiated cancer, the cells were isolated while in differentiated cancer, they formed nodules with indistinguishable cell boundaries.

Adult↗
PubMed1980

Results of total gastrectomy for gastric cancer.

To compare the results of total gastrectomy performed during the last 30 years, we classified 256 patients into four chronologic groups. Despite advances facilitating early detection of gastric cancer, the percentage of patients with stage IV cancer was not significantly different among the four groups. However, operative mortality decreased and curability increased in the two most recent groups. The 5 year survival rate was significantly increased in patients operated on after 1960. Our results show that in Japan, operative mortality and 5 year survival compare favorably with reports from Western countries.

Adult↗
PubMed1980

Therapeutic significance of noncurative gastrectomy for gastric cancer with liver metastasis.

The therapeutic significance of noncurative gastrectomy for gastric cancer with liver metastasis was evaluated and the histologic characteristics of such cancer examined. The mean postoperative survival time of patients with liver metastasis limited to one lobe or a few scattered metastases to both lobes without peritoneal metastasis or direct cancer invasion to other organs was significantly prolonged by noncurative gastrectomy. Differentiated adenocarcinoma, including papillary adenocarcinoma, and intravenous cancer invasion were found to be the histologic characteristics of gastric cancer with liver metastasis.

Adenocarcinoma↗
PubMed1980

A scanning electron microscopic study on the peritoneal implantation of ascites hepatoma AH100B cells in rats.

The process and mechanism of peritoneal metastasis of tumor cells were studied experimentally by means of scanning or transmission electron microscopy, employing rat ascites hepatoma AH100B. Adhesion of tumor cells by microvilli and/or pseudopodia to the mesothelium was observed within 1 approximately 3 days after inoculation when there was no morphological changes of the mesothelial cells. Some changes of the mesothelial cells, such as irregularity, atrophy, and exfoliation, followed tumor cell adhesion 5 or 6 days after inoculation. It was noted that tumor cells adhered to the mesothelium first where no morphological changes were induced, and it is suggested that tumor cells infiltrate into the submesothelial tissue through mesothelial defects.

Animals↗
PubMed1979

[Clinical significance of serum bile acid radioimmunoassay in hepatobiliary diseases--with special reference to the CG/SLCG ratio (author's transl)].

Both serum cholylglycine (CG) and sulfolithocholylglycine (SLCG) levels were radioimmunoassayed by PEG method in 209 samples (204 hepatobiliary diseases, 5 normal controls). 1) The results revealed that serum bile acid levels were excellent indicators for hepatic dysfunction in comparison with the conventional liver function tests. 2) Means of 19.4 +/- 9.3 microgram/dl for CG and 21.7 +/- 6.7 microgram/dl for SLCG were obtained in controls. Most hepatobiliary diseases demonstrated abnormally high bile acid levels, with extremely high CG values in conditions with bile stasis. 3) To differentiate various hepatobiliary diseases more clearly, the ratio of the primary and secondary bile acids (CG/SLCG ratio) was introduced (1.0 +/- 0.6 for controls). In cases of bile stasis, CG/SLCG ratios ranged from 7.8 +/- 4.8 for intrahepatic cholestasis to 34.8 +/- 27.6 for congenital biliary atresia, while other hepatic disorders demonstrated relatively low values. We conclude that the CG/SLCG ratio is a useful index for cholestasis. Diagnosis of the congenital biliary atresia could be possible.

Biliary Tract Diseases↗
PubMed1979

Stomal polypoid hypertrophic gastritis: a polypoid gastric lesion at gastroenterostomy site.

Four cases of stomal polyps (the so-called gastritis cystica polyposa--GCP) at the gastroenterostomy site were studied with detailed description of their macroscopic and histologic features. Thirty-eight cases with reresection of the stomach including the site of previous gastroenterostomy were used for a comparative study. In 25 (66%) of the 38 cases localized mucosal hypertrophy of varying degrees was recognized near the site of anastomosis, the morphology corresponding well, though of the smaller scale, to that of the GCP both macroscopically and histologically. Macroscopic and histologic continuity was traced between the minimal protrusion of the stomal gastric mucosa and the stomal polyps. It is suggested that the GCP is an extreme occasion of stomal gastritis characterized by atrophy and pseudopyloric gland metaplasia of the fundic glands often with their submucosal invasion and hyperplasia of the surface and foveolar epithelia, these being probably caused by reflux of duodenal contents. It must be borne in mind that such lesions do exist at the site of gastrojejunostomy to be strictly differentiated from malignancies at the gastric stump.

Adult↗