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Biomedical subjects

S Kitamura

Publications and source records attributed to S Kitamura.

At least 955 records · Page 53Linked to original sources
PubMed1983

Reversibility of the left ventricular function after aortic valve replacement for aortic regurgitation.

Ten patients with aortic regurgitation underwent aortic valve replacement using a Björk-Shiley valve prosthesis. They ranged from 27 to 58 years of age. The studies were centered around the postoperative hemodynamics, especially concerning the function of the left ventricle during a follow-up period which averaged about 8 months. The left ventricular end-diastolic volume (LVEDV) returned to the normal range, and the muscle mass of the left ventricle decreased remarkably after surgery. The ejection fraction and mean velocity of the circumferential fiber shortening both increased up to the normal range. The left ventricular end-diastolic pressure exhibited normal values with a decrease of the LVEDV. The depressed left ventricular function was largely reversible after surgery.

Adult↗
PubMed1983

Trend of macroangiopathy in diabetics studied by postmortem examination.

In recent years, both a numerical and relative increase in the morbidity of cardiovascular and cerebral vascular diseases has been noted in Japanese diabetics. The trend of macroangiopathy in the period between 1953 and 1980 was studied in 210 autopsy cases (Group A: 1953-62, 27 cases, Group B: 1963-72, 43 cases and Group C: 1973-80, 140 cases). The incidence of myocardial infarction and cerebral infarction as a primary cause of death was 25. 9% in Group A, 23.3% in Group B and 37.9% in Group C. From the autopsy findings, the morbidity of cardiovascular disease was 14.8%, 30.2% and 34.3% respectively. In order to elucidate the clinical risk factors, the age at death, duration of diabetes at the time of death, and incidence of hypertension and serum cholesterol in the past history were studied. The percentages of those aged over 70 at death was 18.5%, 23.3% and 42.8% respectively, and those of the cases with durations of more than 10 years was 25.9%, 40.5% and 51.8% respectively. The prevalence of hypertension and hypercholesterolemia was almost identical in each group. From the above, the previous increase in the death-rate due to coronary heart disease and cerebrovascular disease in Japanese diabetics is thought to be attributable to the increasing number of elderly diabetics of long duration.

Adult↗
PubMed1983

[Experimental studies on distribution of cefotiam, a new beta-lactam antibiotic, in the lung and trachea of rabbits. II. Combined effects with serratiopeptidase].

Plasma levels and distribution in pulmonary and bronchial tissues of CTM following injection into the jugular vein were investigated in rabbits with experimental pleuritis or pneumonitis as well as in normal rabbits. The experiments also included the assessment of the effect of concomitant administration of serratiopeptidase (TSP). The pneumonitis + TSP group, pleuritis group and pleuritis + TSP group showed a tendency to delayed dissipation of CTM from the plasma, as compared with controls. The CTM concentrations in tissues from the apical region of upper lobe (L1), lateral region of middle lobe (L2) and diaphragmatic region of lower lobe (L3) 30 minutes after injection did not differ significantly between the control and the TSP group, pleuritis group or pleuritis + TSP group. In the pneumonitis group, the tissue CTM concentrations at all 3 sites (L1, L2, L3) were lower than those in the control group. They were increased by the concomitant administration of TSP, with statistical significance of increase in regions L2 and L3. Thirty minutes after the injection of CTM, the pneumonitis group and pneumonitis + TSP group displayed essentially comparable CTM levels in pleural fluid, whereas the CTM concentrations in the pleural fluid were prone to be increased in the pleuritis + TSP group as comparing with the pleuritis group. CTM levels in the tissues of trachea (B0), right and left main bronchi (B1) and lobar bronchi (B2) 30 minutes after the injection did not show any significant difference between control and TSP-treated normal groups. CTM concentrations tended to be increased, yet not significantly, in all these regions in the rabbits with pleuritis administered TSP, compared to those without TSP.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗