Search PubMed⌕ Search

Biomedical subjects

S Kitamura

Publications and source records attributed to S Kitamura.

At least 919 records · Page 51Linked to original sources
PubMed1984

New method for local drug delivery using resorbable base material in periodontal therapy.

A new method for local drug delivery to the subgingival plaque was developed using hydroxypropylcellulose (HPC) as a base material. Using this material prepared in the form of strips containing antimicrobial drugs, the clinical and microbiological effects by this method on the human periodontal disease were studied. Before the clinical trials, the rate of the drug release from the strips was studied. Both drugs used in this study (CH: chlorhexidine and TC: tetracycline) were released almost within 2 hours from the strips in vitro. In the gingival crevicular fluid, however, it was found that the TC was maintained for 24 hours after the local delivery. Five patients who had deep pockets contralaterally were selected. The CH-containing HPC strips (5%) were applied in one pocket of each patient and the placebo strips were applied in other pocket on day 0, 2 and 4. Plaque Index, Gingival Index, probing depth and the presence or absence of bleeding on probing were recorded on day 0, 2, 4 and 6. Marked reduction of bleeding on probing was found in the pockets applied the CH-containing HPC strips. There was a significant reduction in the proportion of Bacteroides asaccharolyticus in these pockets (p less than 0.01).

Anti-Infective Agents↗
PubMed1984

Total cavopulmonary shunt operation in complex cardiac anomalies. A new operation.

Four patients with presently uncorrectable cyanotic cardiac anomalies underwent a new operation, "total cavopulmonary shunt operation" or "total right heart bypass operation." These anomalies included single ventricle, single atrium, common atrioventricular valve with or without regurgitation, pulmonary stenosis, and most important, absent inferior vena cava with azygos or hemiazygos continuation. All patients had had previous systemic-pulmonary shunts. The new operation consisted of end-to-side anastomosis between the superior vena cava with azygos or hemiazygos continuation and the confluent pulmonary artery, division or ligation of the pulmonary artery trunk, and replacement of the common atrioventricular valve when regurgitation was present. Thus total venous return, except for hepatocardiac venous and coronary sinus flow, drains directly into the pulmonary artery, bypassing the right atrium and ventricle. Three patients survived the operation, and two of the three patients are now alive 4 years, 8 months and 2 years, 6 months after the operation. The two long-term survivors are in significantly improved condition, both clinically and hemodynamically. We believe that this new operation is promising in the treatment of the otherwise uncorrectable complex cardiac anomalies associated with azygos or hemiazygos continuation of the inferior vena cava. A longer follow-up is certainly mandatory before final conclusions can be reached.

Adult↗