Search PubMed⌕ Search

Biomedical subjects

S Kitamura

Publications and source records attributed to S Kitamura.

At least 865 records · Page 48Linked to original sources
PubMed1985

[Current problems in the surgical treatment of acquired heart disease].

Two hundred and ninety patients with ischemic heart disease and two hundred and sixty one patients with valvular heart disease have been operated upon in our department. Combined valvular and coronary artery surgery was carried out in 19 cases, coronary artery and peripheral vascular surgery was carried out in 7 cases, and tricuspid valve replacement with SJM was carried out in 20 cases. Early mortality rate of combined valvular and coronary artery surgery was 26%, and late mortality 21%, however, only 3 cases (15.8%) died of LOS. Mortality rate of combined coronary artery and peripheral vascular surgery was 43%, however 1 patient died of LOS. Mortality rate of TVR with SJM was 15% which was rather low in comparison with other valves. A patient who underwent simultaneous surgical treatment of valvular or peripheral vascular disease, and coronary artery disease, ran almost the same risk of LOS as patients without ischemic heart disease. However, myocardial protection was important for these patients because of severe LV dysfunction and myocardial hypertrophy. There is not yet an ideal artificial valve for TVR. At present, SJM is the best available valve in terms of design and hemodynamics.

Adult↗
PubMed1985

[Evaluation of the effectiveness and safety in the use of cold-diltiazem-potassium cardioplegia in coronary artery bypass surgery: a first clinical trial].

The effectiveness and safety of diltiazem (DIL), a slow channel calcium blocker, added in cold potassium cardioplegic (CP) solution was evaluated in coronary artery bypass graft (CABG) surgery for 2 purposes; (1) protection of ischemic myocardium during cardiac arrest and (2) prevention of perioperative coronary artery spasm (PCS). Diltiazem of 15 mg was added to a liter of CP which was administered 10 ml/kg B.W. initially and 5mg/kg thereafter. The serum concentration of DIL was 570 ng/ml at the time of aortic declamping, 210 ng/ml at cardioversion and 150 ng/ml one hour after surgery. The left ventricular stroke work index was increased significantly (p less than 0.05) in patients treated by DIL-CP, compared with the patients treated by regular CP without DIL. However, CPK-MB values were not significantly different in either group. The incidence of PCS has decreased from 9.1% to 0.8% (p less than 0.01) after the use of DIL-CP. Perioperative myocardial infarction rate has also decreased from 5.5% to 1.6%. No major or long-lasting side-effects were encountered. We consider that DIL-CP is a safe and excellent CP in CABG surgery and we are now utilizing this CP in all patients requiring CABG surgery.

Adult↗
PubMed1985

Cognitive performance and academic achievement of Japanese, Chinese, and American children.

Chinese, Japanese, and American children at grades 1 and 5 were given a battery of 10 cognitive tasks and tests of achievement in reading and mathematics. Samples consisted of 240 children in each grade in each culture. 2 major purposes of the study were to determine possible differences in cognitive abilities of Japanese, Chinese, and American children and to investigate the possible differential relation of scores on cognitive tasks to reading by children of the 3 cultures. Similarity was found among children of the 3 cultures in level, variability, and structure of cognitive abilities. Chinese children surpassed Japanese and American children in reading scores; both Chinese and Japanese children obtained higher scores in mathematics than the American children. Prediction of achievement scores from the cognitive tasks showed few differential effects among children of the 3 cultures. The results suggest that the high achievement of Chinese and Japanese children cannot be attributed to higher intellectual abilities, but must be related to their experiences at home and at school.

Achievement↗
PubMed1985

Multiple primary cancers in autopsy cases of Tokyo University Hospital (1883-1982) and in Japan Autopsy Annuals (1974-1982).

Multiple primary cancers in 30,386 consecutive autopsy cases from 1883 to 1982 in Tokyo University Hospital and 273,796 registered autopsy cases from 1974 to 1982 in Japan were examined. The frequency of multiple primary cancers among all cancers at Tokyo University Hospital was less than 0.5% until 1940. From 1960, it gradually increased, reaching 6.9% (1970-1982). The average age of patients with a single cancer was around 45 years until 1960. Thereafter, it became high, averaging 54.2 years in 1970-1982. The average age of patients with two and three or more primaries in 1970-1982 was 62.1 and 68.5, respectively. As the autopsy rate of cancers in Japan is 11.1% in 1974-1982, the statistics from the Autopsy Registry are highly representative of those in Japan. The frequency of multiple primaries was 5.5% in the Registry and increased year by year (3.6% in 1974 to 7.1% in 1982). The average age of patients with one, two and three or more primaries was 58.9, 66.7 and 69.8. In these two series, the older the patients, the larger was the number of primaries. In multiple cancers, the frequent combination consisted of the stomach, lung, colon, liver, prostate and thyroid. The stomach, lung, colon and liver were frequent primary sites when they occurred singly. The thyroid and prostate were frequent primary sites found at autopsy. Senescence of the Japanese population is suggested as one of the factors for an increase of multiple primaries in the last 20 years.

Adult↗
PubMed1985

Anti-acetylcholine receptor antibody titer with extended thymectomy in myasthenia gravis.

Twenty-four patients with myasthenia gravis of Osserman's generalized type underwent extended thymectomy through a sternal-splitting approach. Their clinical responses to thymectomy and postoperative changes in anti-acetylcholine receptor antibody titers were evaluated. The follow-up time ranged from 1 month to 7 years and 7 months (average, 36 months). Six patients (25%) had remissions and 17 patients (71%) were improved after operation. The preoperative anti-acetylcholine receptor antibody titers dropped significantly after operation (p less than 0.001). The postoperative reduction in these titers correlated with the time course after operation (p less than 0.05). Their postoperative reduction was significantly greater in the six patients having remissions than in the 15 having marked (p less than 0.02) and the six having moderate improvement (p less than 0.005). This study has revealed that anti-acetylcholine receptor antibody titer in plasma declines progressively after thymectomy, and the postoperative reduction of this titer correlates with the clinical effect of thymectomy.

Adolescent↗