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Biomedical subjects

S Kay

Publications and source records attributed to S Kay.

At least 127 records · Page 7Linked to original sources
PubMed1981

Angiosarcoma and other vascular tumors of the breast.

Vascular tumors of the breast, with the exception of perilobular hemangiomas, are generally considered to be malignant. The pathologic and clinical features of 40 patients with angiosarcoma of the breast and 12 with other vascular tumors of the breast were reviewed. Three general histologic patterns of growth were identified among the angiosarcomas and were found to correlate closely with prognosis. Whereas 10 of the 13 patients in histologic Group I were alive and free of disease with an average follow-up of nearly 6 years, only two of 16 Group III patients were free of disease, and 14 have died. The six Group II patients had a survival similar to those in Group I. In this series the disease-free survival at 3 years was 41% and at 5 years 33%, much better than that reported in previous reviews of mammary angiosarcoma. The data also indicated that adjuvant chemotherapy, specifically actinomycin D, is effective in some and possibly all patients with angiosarcoma of the breast. The 12 other vascular lesions had distinctly different morphologic features, a benign clinical course, and should probably not be viewed as angiosarcomas. However, total excision of all vascular lesions of the breast is essential in order to determine both the diagnosis and the appropriate therapy.

Adult↗
PubMed1981

The pigmented portio: benign lentigo of the uterine cervix.

The first case of benign lentigo of the uterine cervix is reported, providing further evidence that the cervix is able to form the entire spectrum of melanocytic lesions known to occur in the skin. Review of the literature reveals 19 cases of primary malignant melanoma of the cervix and 30 cases of blue nevus. The reported case offers support that benign lentigines may play a role as premalignant lesions of malignant melanoma not only in the skin, but aldo in mucous membranes.

Adult↗
PubMed1978

Ultrastructural comparison between skeletal muscle and cardiac rhabdomyomas.

The electron microscope features of three primary cardiac rhabdomyomas and one skeletal muscle rhabdomyoma arising from the floor of the mouth are compared, along with a review of the previously reported ultrastructural features of skeletal rhabdomyomas. Cardiac rhabdomyoma filaments appear more orderly and have features suggestive of origin from both Purkinje and myocardial fibers. Zebra bodies were seen exclusively in the cardiac rhabdomyomas. In comparison, the extracardiac rhabdomyoma filaments were more disorderly and many cases had hypertrophic Z bands corresponding to the jackstraw or matchstick structures seen with the light microscope. This finding, along with the presence of satellite cells, was not seen in the cardiac rhabdomyomas.

Heart Neoplasms↗
PubMed1978

Inflammatory fibrous histiocytoma (? anthogranuloma). Report of two cases with ultrastructural observations in one.

Two cases of inflammatory fibrous histiocytoma are presented, one occupying the pleural space, and the other the retroperitoneum. One of the cases was studied with the electron microscope and confirmed the histiocytic and xanthomatous nature of the lesion. It is suggested that the term xanthogranuloma be replaced by fibrous histiocytoma, and that when a considerable inflammatory component is present in the stroma, a guarded prognosis be entertained. Ultrastructurally there are no distinctive features for the inflammatory variant of the fibrous histiocytoma.

Histiocytoma, Benign Fibrous↗
PubMed1978

Preoperative radiotherapy for stage III carcinoma of the breast.

We have concluded from these observations in this pilot study that preoperative radiation therapy does not play a particularly helpful role in the management of patients who have the clinical finding of borderline operable carcinoma of the breast and it does not improve the survival rate. Patients within this category of locally advanced disease must be considered to have systemic metastatic disease at the time of diagnosis, as has previously been stressed by many. For this reason, any therapy directed to the regional area for local control must be combined with some form of systemic therapy if there is to be any hope for an increase in survival time.

Adult↗
PubMed1977

Nine year follow-up of a case of benign liver cell adenoma related to oral contraceptives.

The case of a 26-year-old women on oral contraceptives who developed a benign liver cell adenoma that was successfully resected is reported. She continued on her oral medication and developed a recurrence 3 years later. On her second laparotomy, the liver tumor was merely biopsied and not removed. Oral contraceptive use was continued for an additional 3 years and then stopped. The tumor has regressed and is no longer palpable or diagnosable. The patient continues to be well 9 years following her first surgical procedure.

Adult↗
PubMed1977

Sclerosing hemangioma of the lung: an endothelial or epithelial neoplasm?

The ultrastructural features of a sclerosing hemangioma of the lung in a 34 year old woman are described. The basic cellular response is thought to be endothelial and not epithelial. These conclusions are based on the finding of Weibel-Palade bodies within the tumor cells in addition to other characteristics generally associated with endothelial cells.

Adult↗
PubMed1977

Morphologic aspects of nuclear bodies in a case of bronchiolar-alveolar carcinoma of the lung.

The ultrastructural features of a bronchiolar-alveolar carcinoma of the lung are described wherein the presence of nuclear bodies in many of the tumor cells were noted. Although these bodies are not viral elements, it is surmised that they may be virus associated and consequently possibly related to the etiology of this tumor. A review of the ultrastructural findings in the pulmonary adenomatosis of sheep is presented, and these are compared with those in human disease. Experimental evidence of an infectious agent responsible for human lung carcinomas is discussed, and possible avenues for future investigation are delineated.

Adenocarcinoma, Bronchiolo-Alveolar↗
PubMed1977

Pathogenesis and treatment of plunging ranulas.

Three patients with plunging ranula, two of which occurred spontaneously and one of which followed removal of the submandibular gland, were treated by excision of the sublingual gland. The sublingual gland is removed through the mouth or through a cervical submandibular incision. No dissection of the cervical ramifications associated with the ranula is undertaken, and these disappear once the source of the extravasating saliva has been removed. Results of considerable experimental work reported by others, support the concept that plunging ranulas are extravasations of saliva from the sublingual glands.

Adolescent↗
PubMed1976

Carcinoma of the gallbladder: staging, treatment, and prognosis.

Sixty-six cases of carcinoma of the gallbladder treated at The Memorial Hospital, Danville, Virginia, and the Medical College of Virginia, Richmond, were staged according to depth of invasion and spread and graded histologically; the findings were correlated with survival. Results from the two hospitals were essentially identical and the survival figures correlated well with 399 reported cases in the medical literature which could be staged according to the depth of invasion. A simple method combining staging and histologic grading of cancer of the gallbladder, which can easily be applied to all cancers of the gallbladder removed surgically and which should prove useful in the management of this disease, is described. Essentially all of the carcinomas of the gallbladder in the series were incidental findings at surgery for gall stones which may explain a relatively high proportion of superficial carcinomas which are cured by the removal of the gallbladder.

Gallbladder Neoplasms↗