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Biomedical subjects

S Kay

Publications and source records attributed to S Kay.

At least 109 records · Page 6Linked to original sources
PubMed1985

Reactive spindle cell nodule of the endocervix simulating uterine sarcoma.

A case of a reparative spindle cell nodule involving the endocervix is reported. The nodule was present in a curetted specimen of the endocervix 2 weeks following an endometrial curettage that showed adenocarcinoma of the endometrium. The lesion was interpreted at first as a carcinosarcoma until the historical facts were appreciated.

Aged↗
PubMed1985

Angiomatoid malignant fibrous histiocytoma. Report of two cases with ultrastructural observations of one case.

Two cases of so-called angiomatoid malignant fibrous histiocytoma are reported herein. One of the cases was studied ultrastructurally, representing, to my knowledge, the fourth such set of observations reported in the literature. It is concluded that the histiocytelike cells making up the bulk of the tumor are modified endothelial cells with histiocytic function, so that the term histiocytoid hemangioma may be a valid one. The principal point of difference, however, is that these tumors as described herein are aggressive with a potential both for local recurrence and metastasis.

Child↗
PubMed1984

Spontaneous healing and relief of pain in a patient with intractable vasculitic ulceration of the lower limb following an intravenous infusion of prostacyclin: a case report.

A case is reported of a patient with diabetes and rheumatoid arthritis who presented with vasculitic ulceration of the lower leg and foot. The ulceration was associated with severe pain and showed no sign of healing despite conservative treatment and skin grafting. At the time when amputation seemed inevitable an intravenous infusion of prostacyclin was given. There was a rapid and lasting relief of pain and the ulcerated area began to heal spontaneously.

Epoprostenol↗
PubMed1984

Fibrous defect (nonossifying fibroma) of the mandible.

Two cases of fibrous defect (nonossifying fibroma) of the mandible are presented. Each case occurred in the mandibular ramus of an 11-year-old girl. The usual fibrous defect of bone is an intraosseous fibrous, nonneoplastic, reactive lesion which appears as a well-delineated defect in the metaphysis of long bones. This report reviews the literature, histopathology, and classification of the fibrous defect of bone.

Child↗
PubMed1984

Improved survival following complete excision of retroperitoneal sarcomas.

Charts and slides of 47 patients with primary retroperitoneal sarcomas (excluding pediatric rhabdomyosarcoma) were reviewed to determine clinical presentation, histologic features, extent of surgical resection, operative morbidity and mortality, use of radiation and/or chemotherapy, and survival data. Most patients presented with pain and a palpable mass. Leiomyosarcomas and liposarcomas were the most common tumors. Eighteen of the 47 patients (38%) had complete tumor excision; 68% required resection of adjacent organs. Operative morbidity was 33% with no mortality. After complete resection, the disease-free 5-year survival was 50% and the overall survival was 70% at 5 years; 10-year disease-free survival was 25% with an overall 58% survival at 10 years. Eleven patients (61%) developed recurrent disease with a median interval of 5 years following complete excision. Six patients received adjuvant radiation and/or chemotherapy with four remaining disease-free from 46 to 61 months. Eighteen patients underwent partial excision of tumor and 11 patients underwent biopsy only; these groups had similar survival curves with only 4% alive at 5 years. Their operative morbidity was 18% and mortality was 7%; median time to clinical evidence of tumor progression was 12 months. Sixty per cent of these patients received therapeutic radiation and/or chemotherapy, but their survival was the same as those undergoing surgery alone. These data emphasize the importance of an aggressive surgical approach in the treatment of retroperitoneal sarcomas. Complete tumor resection and total excision of recurrences will allow many patients long-term survival.

Adolescent↗
PubMed1984

The circumareolar incision: a useful incision for gynaecomastia.

A simple incision for the treatment of gynaecomastia is presented which combines the advantages of adjustment of areolar size and good cosmetic result with increased access when compared with conventional periareolar incisions. This technique has also been used to provide access in augmentation mammoplasty, and could be used for the removal of benign tumours in the periareolar region.

Breast↗
PubMed1983

Hyaline globules and intracellular lumina in a hepatocellular carcinoma.

The authors report ultrastructural findings on the morphogenesis of hyaline globular inclusions (HG) of a moderately well-differentiated hepatocellular carcinoma, with the features of a fibrolamellar variant. Pale blue cytoplasmic inclusions (pale bodies) of the tumor cells were shown to be intracellular lumina lined with numerous microvilli. Our findings suggest that HG were formed apparently by the successive deposition of fine granular materials in the lumina. Small accumulations were present in the intracellular lumina, which were seen on light microscopy as central hyaline cores of pale inclusions. Larger globular deposits, corresponding to HG and presumably mature ones, were lined closely with membranes devoid of microvilli that were probably shed intraluminally. Our observation was discussed with relation to the previous findings on the inclusions.

Adult↗
PubMed1983

Choriocarcinoma of the mesosalpinx masquerading as congestive heart failure: ultrastructural observations of the tumor.

A 45-year-old woman suffered from hypertension and congestive heart failure for 5 months. She was found to have a choriocarcinoma of the left mesosalpinx. The final event was, in all probability, a massive pulmonary tumor embolus which occurred shortly after removal of the uterus and adnexae. The tumor was studied by immunohistochemical methods as well as ultrastructurally, and the findings are illustrated and described.

Adnexal Diseases↗
PubMed1983

The role of prophylactic antibiotics in appendectomy using delayed primary closure.

A prospective randomized trial of prophylactic antibiotics in 202 patients undergoing appendectomy is reported upon. The antibiotics used were metronidazole and cephradine. Half of the patients received antibiotics preoperatively. The other half received antibiotics at operation only upon finding perforation, gangrene or pus formation. All wounds were treated by delayed primary closure. No instance of wound infection, defined as abscess formation or cellulitis, occurred in either group. Antibiotics given prophylactically in every instance appear to have no advantage in preventing wound infection when delayed primary closure is used.

Adolescent↗
PubMed1982

Stercoral ulceration.

Stercoral ulceration is the loss of bowel integrity from the pressure effects of inspissated feces. The lesion usually occurs in constipated, bedridden patients and presents as an isolated lesion in the rectosigmoid area. Because of associated diseases in the population at risk, perforation and hemorrhage, the principal complications, result in a mortality exceeding 50 per cent. The diagnosis of perforated stercoral ulceration should be considered in any patient with a long-standing history of constipation who presents with acute abdominal pain and clinical findings consistent with perforation of a hollow viscus. Early celiotomy with vigorous debridement and irrigation of the peritoneal cavity and either exteriorization or resection with proximal colostomy is the treatment of choice. Since constipation and colonic dysfunction are more common in the older patient, as the mean age of the population increases, the surgeon may encounter this problem more often. Four patients with stercoral ulceration managed at the Medical College of Virginia Hospitals are added to the 53 patients previously reported in the literature.

Adult↗
PubMed1981

Febrile neutrophilic dermatosis associated with acute leukemia.

Febrile neutrophilic dermatosis (Sweet's Syndrome) is an uncommon syndrome characterized clinically by fever, neutrophilia, and erythematous, non-ulcerating papules or plaques on the face, neck, upper thorax, and extremities. A case associated with acute myelogenous leukemia is reported and nine other reported cases associated with acute non-lymphocytic leukemia are reviewed. The appearance and location of the lesions on the face, neck, upper trunk and extremities, a female predominance, an associated fever, marked dermal infiltrates of mature neutrophils, and rapid clearing of lesions with parenteral corticosteroids were manifestations similar to febrile neutrophilic dermatosis not associated with leukemia. Although the etiology of febrile neutrophilic dermatosis associated with acute leukemia is unknown, the resolution of lesions and symptoms with systemic corticosteroids and recurrence with relapse of leukemia suggests an immune process with the leukemic cell population serving as a possible antigenic source.

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