Ophiasis inversus: a rare pattern of alopecia areata.
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Alopecia Areata↗
Biomedical subjects
S Kaur
Publications and source records attributed to S Kaur.
Scrofuloderma with multiple organ involvement in a 5-year-old child.
Cutaneous tuberculosis is a rare form of extrapulmonary tuberculosis seen in children in developing countries. We report a 5-year-old child with cutaneous tuberculosis with involvement of lymph nodes, lungs, and the musculoskeletal and central nervous systems, which was not clinically obvious. Antituberculous treatment led to marked clinical improvement. The importance of a thorough search for internal organ involvement in patients presenting with cutaneous tuberculosis is emphasized.
Antitubercular Agents↗
Kikuchi disease with facial rash and erythema multiforme.
Kikuchi disease, or histiocytic necrotizing lymphadenitis, is a benign illness characterized by fever and cervical lymphadenopathy predominantly in young women. It has a self-limiting course. Skin changes occur in about one-third of patients and are of a nonspecific nature. A case of Kikuchi disease with cutaneous involvement in the guise of erythema multiforme and a facial rash is reported. The differential diagnosis with systemic lupus erythematosus and Rowell syndrome is discussed.
Biopsy↗
Chitosan microspheres prepared by an aqueous process: release of indomethacin.
Chitosan microspheres loaded with indomethacin were prepared using only aqueous solvents. The influence of formulation variables on indomethacin content in the microspheres and time for release of 66.6% of indomethacin from the microspheres was investigated. Amongst various variables, the indoemthacin:chitosan ratio and amount of crosslinking agent were important. Response surfaces were generated to optimise the aqueous process with respect to these critical variables, in order to obtain maximum indomethacin loading and optimum t66.6.
Capsules↗
Endothelin as a therapeutic target in the treatment of cardiovascular disease.
Endothelins, a family of peptides derived from the vascular endothelium and smooth muscle cells possess vasoconstrictor and mitogenic properties. By acting predominantly in a paracrine fashion, these peptides activate specific receptors and have protean effects in normal and diseased organ systems. The wide distribution of these receptors in various tissues mediate the multiplicity of physiologic actions attributed to endothelins. Much of our understanding about endothelins has come from the development of an array of receptor-specific and mixed receptor antagonists. Based on the promising results from animal studies, active research and drug development programs are under way to investigate the clinical potential of endothelin antagonism for treatment of cardiovascular disease.
Animals↗
Sulzberger-Garbe dermatosis in an Indian patient.
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Humans↗
Effects of low doses of alpha chlorohydrin on the dehydrogenases and oxidases of rat epididymal epithelium and sperms: a correlative histochemical and biochemical study.
Histochemical studies have been made of the isocitrate dehydrogenase, succinic dehydrogenase, malate dehydrogenase, glutamate dehydrogenase, DPN diaphorase, TPN diaphorase, delta 5-3 beta-hydroxysteroid dehydrogenase and monoamine oxidase in the caput, corpus and cauda epididymides of normal and alpha chlorohydrin (6.5 mg/kg/9 days) treated rats. Administration of alpha chlorohydrin in a low dose caused a conspicuous decrease in all these enzymes except delta 5-3 beta-HSD, in various cell types of epididymal epithelium and sperms. Biochemical estimations of isocitrate dehydrogenase, succinic dehydrogenase, malate dehydrogenase and delta 5-3 beta-HSD have further supported and confirmed these histochemical observations. These changes in enzyme activities after treatment with low dose of alpha chlorohydrin strongly suggest that TCA cycle and amino acid metabolism of epididymis become defective, much earlier before any histological damage to the epididymis becomes visible.
3-Hydroxysteroid Dehydrogenases↗
Effect of low doses of alpha chlorohydrin on the dehydrogenases and oxidases of rat testis. A histochemical study.
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Animals↗
Modulatory influence of the oral contraceptive pill, Ovral, on 3-methylcholanthrene-induced carcinogenesis in the uterus of mouse.
The present study examines the modulatory influence of the combined oral contraceptive pill, Ovral (0.05 mg ethynylestradiol plus 0.25 mg levonorgestrel per pill) on methylcholanthrene (MCA)-induced carcinogenesis in the uterus of Swiss albino mouse. Placement of cotton thread impregnated with beeswax containing approximately 600 micrograms of MCA, yielded endometrial squamous cell carcinomas in 53.33% animals in 90 days. Concomitant treatments with doses D1 (1/200th of a pill) and D2 (1/200th of a pill) of Ovral yielded endometrial squamous cell carcinomas in 6.23 and 0% of animals in 90 days (p < 0.05; p < 0.005) respectively. Ovral did not seem to increase the incidence of uterine hyperplasia.
Animals↗
Implementing professional profiling.
This year, UKCC requirements for maintaining an effective registration will necessitate practitioners keeping professional development details in a personal professional profile. This article describes the former Yorkshire Regional approach in preparing for this event and the workshop experiences.
Education, Nursing, Continuing↗
A comparative evaluation of bacteriologic and morphologic indices of Mycobacterium leprae in skin, lymph node, bone marrow, nerve and muscle.
This study elicits the comparative evaluation of the Bacteriologic Index (BI) and Morphologic Index (MI) of the skin, lymph node, bone marrow, nerve and muscle tissues of 15 untreated leprosy patients. The findings of comparable or even higher BI's and MI's in lymph nodes than skin are of considerable interest, especially the presence of a significant percentage of viable bacilli during reaction states when MI of skin and nerve tissue was found to be negative. Evaluation of the BI's and MI's of lymph nodes has been suggested to be of utmost importance for follow-up studies of patients being treated with antileprosy drugs.
Adolescent↗
Nitric oxide derivative in bronchoalveolar lavage fluid from patients with idiopathic pulmonary fibrosis.
Idiopathic pulmonary fibrosis is a chronic inflammatory disorder of unknown aetiology with a number of inflammatory cells playing a role in its pathogenesis. In this study, we have attempted to find out the possible role of nitric oxide in its pathogenesis by way of measuring the nitrite and nitrate levels in the bronchoalveolar lavage fluid. Ten patients of histologically proved idiopathic pulmonary fibrosis and 10 controls (5 with normal chest skiagrams and 5 with sarcoidosis) were included in the study Bronchoalveolar lavage was carried out in these cases. The levels of nitrates and nitrites were increased in cases of idiopathic pulmonary fibrosis (0.77+/- 0.36 and 8.93 +/- 2.63 nmol/mg of protein) compared to those in controls (0.38 +/- 0.06 and 3.80 +/- 1.11, respectively for sarcoidosis patients); (0.39 +/- 0.13 and 6.56 +/- 1.61 for subjects with normal chest skiagrams). These differences were statistically significant (p < 0.05 to 0.01). These findings suggest a possible role of nitric oxide in the pathogenesis of idiopathic pulmonary fibrosis.
Adult↗
Changes in the industrial structure of India's male working force, 1961-81.
The post-Independence period in India has witnessed a gradual decline of some occupations and services and the emergence of others. In the present paper an attempt has been made to analyze the change in the industrial structure of India's male working force by calculating an index of change. The index so calculated for 2 decades separately (1961-1971 and 1971-1981) is portrayed cartographically. The overall low degree of change recorded by the country's male working force establishes the weakness of India's industrial infrastructure. Consequently, the secondary sector seems to have failed in generating employment opportunities on a large scale. Regionally, the peripheral areas have recorded a higher incidence of change than the interior heartland of the country. The areas that were overwhelmingly agricultural and had experienced developments in the field of agriculture alone exhibited a low degree of change in comparison to those that had experienced developments both in the field of agriculture and industry. During the last inter-censal period (1971-1981) the country recorded an accelerated rate of change in the industrial structure of its male working force. Spatially too, the increasing rate of change has spread to new regions.
Agriculture↗
Split hand-foot malformation: a congenital central limb ray deficiency.
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Abnormalities, Multiple↗
A clinical and radiological study of maxillary antrum in lepromatous leprosy.
Seventy consecutive patients having multibacillary leprosy were questioned about symptoms of nasal involvement and sinusitis. Complete otorhinolaryngeal examination was carried out in all these patients and they were subjected to radiographic examination of paranasal sinuses. Radiological abnormality of maxillary antrum was found in 40 (57%) patients. Radiological changes were unilateral in 25 and bilateral in 15 patients. Localised or generalised mucosal thickening was the most common finding, followed by diffuse opacity. The development of radiological changes in maxillary antrum correlated with high bacterial density (BI 3+ and above), nasal deformity, and disease duration of more than two years.
Adolescent↗
Radiological changes in hands and feet in disabled leprosy patients: a clinico-radiological correlation.
Seventy-six consecutive leprosy patients with disabilities were subjected to radiological examination of hands and feet, and bone changes were found in 63 of them (82.9%). Specific, nonspecific and osteoporotic bone changes were observed in 22.4%, 78.9% and 28.9% of cases respectively. Bone cysts (10.5%), subarticular erosions (10.5%) and enlargement of nutrient foramina (5.3%) were the common specific bone changes whereas bone absorptive changes (59.2%), soft tissue changes (39.5%) and concentric absorption (39.5%) were the most frequent nonspecific bone changes. Specific bone changes were more common in older patients (age 40 years) and nonspecific bone changes correlated with duration of disease, duration of deformity, and disability index. Osteoporotic bone changes were found to be affected by ageing and severity of disability of hands and feet.
Adolescent↗
Paucibacillary multidrug therapy in leprosy. 7 1/2 years experience.
Three hundred and twenty-three paucibacillary (PB) leprosy patients were treated with WHO-recommended multidrug therapy (MDT) and followed up for over 7 1/2 years. The paucibacillary MDT regimen (PBR) was well accepted and tolerated. Complete clinical regression was attained in 61.2% patients after 6 doses of PBR. Persistence of clinical activity after 6 months of therapy was associated with occurrence of type I upgrading reaction, presence of six or more patches and more than two thickened major nerve trunks. Reversal reactions were encountered in 15.9% patients, one third of which were accompanied by severe neuritis. Delayed upgrading reaction occurred in six patients, two patients had relapse one and two years after stopping of PBR. The WHO recommended MDT regimen for paucibacillary cases needs careful evaluation and it may be necessary to extend the treatment beyond six months in certain situations.
Adolescent↗
The interaction of barbiturates and analeptics.
The interaction of pentobarbitone sodium with three analeptics viz. micoren, pentylenetetrazol and methedrine was studied in mice. Micoren prolonged pentobarbitone sleeping time. pentylenetetrazol shortened the sleeping time. Methedrine also shortened the sleeping time, but clonic convulsions of mild to severe intensity were noticed 45-60 minutes after the drug injection.
Aminobutyrates↗