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Biomedical subjects

S Katz

Publications and source records attributed to S Katz.

At least 505 records · Page 28Linked to original sources
PubMed1975

The detection of aberrant DNA synthesis in a member of a high-risk cancer family.

Relatives of patients with multiple polyposis are among those at high risk for development of neoplasms in the colon. Examination of 4 siblings, 3 men and 1 woman, of a patient with multiple polyposis was conducted for the possible presence of colonic polyps. All patients were over 40 years of age and received barium enemas for the radiological detection of excrescences. Proctoscopic examinations were also carried out during which time a biopsy and colonic wash were obtained. Polyps were absent on films as well as on endoscopy, and colonic cytologies of all 4 subjects were within normal limits. However, isotopic incorporation studies revealed the presence of an abnormal labeling pattern in some crypts of the biopsy incubated with TdR-3H of 1 family member. Along with normal crypts with label in the lower two-thirds of the colonic crypts, some were seen to have cells labeled at the surface, a proliferative lesion thought to precede the apperarance of a polyp. Among the surface cells removed by the colonic wash, some were found to be isotopically labeled, that is, engaged in DNA synthesis. Thus, a defect in the regulation of colonic epithelial cell replication was found, suggesting the need for close surveillance in the interest of early colon cancer detection.

Adult↗
PubMed1975

Semen zinc levels in infertile and postvasectomy patients and patients with prostatitis.

The semen zinc levels were determined in 18 volunteers, 132 patients postvasectomy, and in 19 patients with prostatitis. The mean values for semen zinc were the same in the volunteers and postvasectomy patients. However, the mean zinc concentration in the volunteers and postvasectomy patients was significantly different from that of the patients with prostatitis. When a group of 12 patients with prostatitis was given supplementary zinc sulfate, the levels of semen zinc rose dramatically and were significantly different from those before treatment. As part of an infertility evaluation, 153 specimens from 72 men who had not fathered a child were examined. A complete semen analysis of each specimen was made, including the semen zinc concentration. The specimens were separated into four arbitrary groups with differing fertility potential. The groups were organized by sperm counts (less than 20 million sperm/ml, 20 to 60 million sperm/ml, 60 to 100 million sperm/ml, and greater than 100 million sperm/ml). There was a trend toward increasing zinc concentrations in the groups with increasing fertility potential. Eleven patients with oligospermia and low semen zinc levels were given supplementary zinc sulfate, 80 mg three times/day for 6 months to 1 year. The parameters of the semen analysis improved in all categories. There were three pregnancies during the period of treatment.

Cell Count↗
PubMed1975

Factors related to the cariogenic potential of breakfast cereals.

Reported is a series of studies in which several breakfast cereals were tested for the following properties: sugar retained by, and plaque formed on, extracted teeth that chewed the cereals: ability of the cereals to induce acid formation when incubated with saliva and to neutralize acids when mixed with water: and, as a summary, ability to induce caries formation under mouth-simulation conditions. It was found that the cariogenic potential of the cereals tested is not dependent upon their sugar content, their retentiveness on the teeth, the amount of sugar retained by the teeth, or the amount of plaque formation they induced on the teeth. The only parameter that related well with the carcinogenic potential of the cereals was their buffering (or acid-neutralizing) ability: the greater the buffering, the lesser the carcinogenic potential. These results, which were confirmed in independent animal studies, case some doubts upon the role traditionally attributed to sugars in caries formation. At least they caution against generalizations and point out other factors that should be studied before a thorough understanding of the factors determining the cariogenicity of foods can be gained.

Acids↗