Biomedical subjects
Publications and source records attributed to S Kapoor.
Anomalies of the nose, larynx and oral cavity are described in two patients with cryptophthalmos. A teratogen acting at the time of lid fold formation is probably responsible for the ocular and systemic involvement which are primarily ectodermal defects with some mesodermal involvement.
A pedigree showing anterior lenticonus, posterior lenticonus and deafness with sex-linked inheritance and the probable gene locus in the short-arm of X chromosome is described.
Anterior lenticonus is reported in a 20-year-old female who had perceptive deafness, albuminuria, microscopic haematuria, pyuria, primary amenorrhoea, aplasia of the uterus and poorly developed external genitalia. Chromosomal study revealed 45 XO pattern. It is suggested that the gene for anterior lenticonus is recessive and is carried in the short term of the X chromosome.
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A diploic dermoid involving the orbital plate of the frontal bone is described in a 52-year-old man. It presented proptosis, downward displacement of the globe and limitation of its movement while looking up. Its extension into the anterior cranial fossa was detected by injecting a radio-opaque material into the cyst.
A 40-year-old female with a basal-cell carcinoma in maxillary osteomyelitis is reported. Blood-stained discharge from a sinus associated with ulceration of the infra-orbital region and the onset of blindness wree the presenting features. It is suggested that biopsies from multiple sites of the lesion rather than reliance on the clinical picture would help in detecting early malignant change.
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Ocular cysticercosis is frequent in Andhra and Tamilnadu states of India due to the unhygienic habits of local people. The conjunctiva is the commonest site of ocular involvement in India while the vitreous and the retina are the usual sites of pathology elsewhere.
A case of anterior lenticonus with haematuria and sensorineural deafness is presented. It is suggested that the anterior lenticonus forms an important clue to the diagnosis of Alport's syndrome which can be confirmed by detailed audiometric examination and urine analysis of other family members.
A South Indian family with three well documented cases of Alport's syndrome with anterior lenticonus are reported. Clinical features of the syndrome including ocular and laboratory findings have been presented and discussed. Macular pigmentation, 5 cases, subcapsular opacity and nephrotic syndrome, one case each, observed in the present series are of great interest and are quite rare in patients with Alport's syndrome. Critical analysis of the family pedigree revealed autosomal dominance with incomplete penetrance as the possible mode of genetic transmission of the disease.
A rare case of free floating cysticercus in the anterior chamber is described which mimiced a dislocated lens. Preoperative use of steroids is advocated not only to controle uveitis but also facilitate surgical removal of the cyst.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.