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Biomedical subjects

S Kamiya

Publications and source records attributed to S Kamiya.

At least 199 records · Page 11Linked to original sources
PubMed1979

Lafora-like bodies in a cat. Case report suggestive of glycogen metabolism disturbances.

Lafora-like bodies in an 8-year-old cat were studied light and electron microscopically and histochemically. In addition ot Lafora-like bodies composed of branching filaments, glycogen granules and electron-dense materaisl, abnormal accumulations of glycogen granules attracted attention. The most remarkable features were the developmental processes of the branching filaments originating directly from glycogen granules. Lafora-like bodies in the present study showed ultrastructural, histochemical, and enzymatic similarities to those described in the previous reports in Lafora's disease, glycogenosm is considered to be probably related to the productive mechanism of Lafora-like bodies.

Animals↗
PubMed1979

Carcinogenic effect of N-ethyl- and N-amyl-N-nitrosourethans on female Donryu rats.

Carcinogenic effect of N-ethyl-N-nitrosourethan (ENUR) and N-amyl-N-nitrosourethan (ANUR) was examined by continuous oral administration or topical application to female Donruy rats. Oral administration of 100 ppm solution of ENUR induced 100% of tumors in the forestomach, 46%, 80%, 71%, and 51% in the oral cavity and pharynx, esophagus, duodenum, and liver, respectively. On the other hand, the incidence of forestomach tumors was 78%, that of oral cavity and pharynx, and esophagus was 93% and 98%, respectively, in rats given 400 ppm suspension of ANUR. In addition, topical application of ENUR induced tumors of the skin as well as tumors of the forestomach and liver.

Administration, Oral↗
PubMed1979

Antitumor effect of pyridine N-oxides having 1-(2-chloroethyl)-1-nitrosoureidoalkyl and 1-methyl-1-nitrosoureidoalkyl groups.

Pyridine N-oxides having 1-(2-chloroethyl)-1-nitrosoureidoalkyl or 1-methyl-1-nitrosoureidoalkyl groups were evaluated for their antitumor activity against AH13 hepatoma and L1210 leukemia. Among them, 1-(2-chloroethyl)-1-nitroso-3-(2-pyridylmethyl)urea N-oxide (1), its tosylate (2), 1-(2-chloroethyl)-1-nitroso-3-(2-pyridylethyl)urea N-oxide (4), and 1-(2-chloroethyl)-1-nitroso-3-(3-pyridylmethyl)urea N-oxide (6) were highly active against both tumors in ip-ip system. These compounds were also active in ip-iv and ip-po systems of L1210. On the other hand, pyridine N-oxides having 1-methyl-1-nitrosoureidoalkyl group were all inactive against AH13 and weakly active against L1210. Effect on blood cells in Donryu rats bearing EDEN-5 erythroblastic leukemia cells was tested with these 1-(2-chloroethyl)-1-nitrosoureidoalkylureas. These compounds caused leucopenia and compound (4) was only slightly effective against EDEN-5.

Animals↗
PubMed1976

Tumors of the upper digestive tract of ACI/N rats given N-propyl-N-nitrosourethan in the drinking water.

Three groups of ACI/N rats of both sexes were given 400, 200, or 100 ppm of N-propyl-N-nitrosourethan (PNUR) continuously in the drinking water. The incidence of tumors in the upper digestive tract was 100% in all 3 groups. These tumors were observed most frequently in the forestomach, followed by the esophagus, oral cavity, and pharynx. Histologically, all the tumors were papillomas or squamous cell carcinomas. A few tumors were detected in the small intestine and glandular stomach. The study on morphogenesis of squamous cell carcinomas arising from the upper digestive tract indicates that the majority of tumors of the esophagus and forestomach may pass through acanthosis or hyperkeratosis, leukokeratosis, and papilloma, and finally develop into invasive squamous cell carcinoma, but many carcinomas of the oral cavity and pharnyx, especially the tongue, may develop without passing through a papillomatous stage.

Animals↗