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Biomedical subjects

S Kamiya

Publications and source records attributed to S Kamiya.

At least 181 records · Page 10Linked to original sources
PubMed1983

Polyglucosan bodies in the digestive tract of the aged dog.

In our recent studies on aging phenomena in animals, polyglucosan bodies (PGB) were found within the smooth muscle in the digestive tract of aged dogs without neurologic signs. PGB were basophilic, round, or oval bodies which appeared to have a homogeneous or concentric shape. Their histochemical properties were characterized by the presence of glucose polymers (polyglucosan). Electron microscopy revealed that PGB were composed mainly of irregularly clustered, short branching filaments measuring about 90 A in width. PGB were histochemically and ultrastructurally identical to the previously reported Lafora-like bodies in the CNS of aged dogs. PGB were found in all aged dogs and were disseminated throughout the digestive tract, especially in the cecum.

Aging↗
PubMed1983

Decreased colony forming ability of human cells persistently infected with baboon endogenous virus. Brief report.

Plating efficiency (PE), i.e. colony forming ability, of primary human embryonic lung fibroblasts persistently infected with baboon endogenous virus (BaEV) decreased to less than 10 per cent of that of the uninfected cells. A line of human amnion (FL) cells showed a 55 per cent reduction of PE after the establishment of BaEV carrier state. No decrease of PE did occur as a result of BaEV persistent infection in a rhabdomyosarcoma cell line (A204) and in fibroblasts derived from adult human skin. This characteristic reduction of PE in the infected primary embryonic fibroblasts was completely abolished by cultivation of the cells with conditioned medium from confluent either virus-infected or uninfected culture.

Adult↗
PubMed1982

Carcinogenicities of 1-ethyl- and 1-amyl-1-nitrosourethans in female donryu rats: dose-effect relations.

Groups of female Donryu rats were given solutions of 100, 50, and 25 ppm of 1-ethyl-1-nitrosourethan (ENUR), and of 400, 200, and 100 ppm of 1-amyl-1-nitrosourethan (ANUR) continuously in the drinking water. The incidence of tumors was nearly 100% in all groups treated with ENUR or ANUR, but with both chemicals the rats showed dose-dependent mean survival times. In the groups treated with ENUR, tumors were most frequent in the upper digestive tract and duodenum, whereas in groups given ANUR tumors were induced only in the upper digestive tract, with none in the duodenum. Tumors of the forestomach were more frequent than those of the esophagus and oral cavity and/or pharynx in groups treated with ENUR. In contrast, the target organs of ANUR were the oral cavity and/or pharynx, and the esophagus, rather than the forestomach. The carcinogenicities of these two chemicals are discussed in comparison with those of other 1-alkyl-1-nitrosourethans.

Animals↗
PubMed1980

Topographic distribution pattern of Lafora-like bodies in the spinal cord of some animals.

The topographic distribution pattern and morphological features of Lafora-like bodies in the spinal cord of the dog, cat, fox, and baboon were examined by light and electron microscopy. The caudal lumbar and the coccygeal parts of the spinal cords were the predilection sites for the bodies in all animals and were very prominent in the ventral columns and intermediate substance. The bodies mainly composed of branching filaments were preferentially located in neuronal processes and rarely in astocytes. The histochemical characteristics of the bodies were identical in all animals and consisted mainly of polyglucosan.

Animals↗