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Biomedical subjects

S K Varma

Publications and source records attributed to S K Varma.

80 records · Page 5Linked to original sources
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Endocrine disorders.

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Adolescent↗
PubMedDate not supplied

Common childhood thyroid disorders.

This article presents current knowledge about common childhood thyroid gland disorders. Included are congenital and acquired hypothyroidism, hyperthyroidism, disorders due to iodine deficiency, tumors and miscellaneous conditions. The significance of early diagnosis by screening and institution of treatment of congenital hypothyroidism is emphasized. Etiology, pathogenesis, clinical signs and symptoms, diagnosis and treatment are discussed.

Child↗
PubMedDate not supplied

Treatment of drooling by parotid duct ligation and submandibular duct diversion.

A new combination of operations is described for controlling drooling in patients with cerebral palsy. Fourteen patients underwent ligation of one parotid duct and diversion of both submandibular ducts at the same operation. Drooling was controlled in all. Transient oro-facial swelling was the commonest complication.

Adolescent↗
PubMedDate not supplied

Metabolic aspects of fetal alcohol syndrome.

A 10% ethanol (ET) solution was the only drinking fluid available for 60 days prior to and during pregnancy which was continued until neonatal rats were weaned. The 18 day old fetus and its liver weight of ET drinking rats were significantly decreased from water drinking controls. Liver and body weights of 14 and 21 day old neonates of both sexes were markedly decreased from controls as a consequence of ET intake. Hepatic cytosolic aldehyde dehydrogenase (ALDH) of 14 day old neonates maintained on ET was increased from water controls without a concomitant change in specific activities of mitochondrial ALDH or or liver alcohol dehydrogenase (ADH). This is contrasted with decreases in hepatic mitochondrial ALDH in 21 day old neonate of both sexes as a function of maternal ET feeding. The postnatal development of L-ALDH activity of offspring of ET-fed rats was less than that of water controls. A transient increase in liver ADH from respective controls was measured in the 21 day old males but not in females of corresponding age. The results suggest that certain metabolic changes in hepatic ET and acetaldehyde metabolism may occur in fetal alcohol syndrome. This may conceivably contribute to one of the mechanism(s) underlying the adverse reaction towards ET and to the susceptibility of the newborn of alcoholic subjects to other related CNS depressants.

Acetaldehyde↗