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Biomedical subjects

S K Varma

Publications and source records attributed to S K Varma.

At least 73 records · Page 4Linked to original sources
PubMed1972

Hyperlactataemia in phenformin-treated diabetics.

Raised fasting blood lactate levels were observed in diabetic patients on phenformin in therapeutic dosage. After an intravenous glucose load this effect was exaggerated and the lactate/pyruvate ratio increased. Withdrawal of the drug led to normal blood lactate levels and a fall in the lactate/pyruvate ratio.

Adult↗
PubMedDate not supplied

Pectus excavatum in children: diagnostic significance for mitral valve prolapse.

Eighty-seven patients with pectus excavatum underwent cardiac examination and echocardiography (M-mode) to determine the diagnostic significance of pectus in children for mitral valve prolapse (MVP). Patients' ages ranged from 1 month to 18 years with a mean age of 5.4 years. Sixty-seven were males. Twenty of the 87 pectus patients (23%) had echocardiographic evidence of MVP, whereas 11 of these had auscultatory findings of a non-ejection click or late systolic murmur, and 4 had significant mitral insufficiency. Fourteen of the 77 patients (18%) with mild pectus, and 6 of the 10 patients (60%) with severe pectus had MVP. Two of the patients (3.4%) with mild pectus and 2 of the patients (20%) with severe pectus also had significant mitral insufficiency. Ten of the 23 patients (44%) older than 8 years of age and 10 of the 64 younger patients (16%) had MVP. Although MVP was present more frequently in females (30%) than in males (21%), the difference was not statistically significant. This study indicates the high incidence of MVP in children of 8 years of age and older, especially when pectus deformity is severe. This information is particularly helpful to heighten suspicion of MVP in children with pectus excavatum.

Adolescent↗