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Biomedical subjects

S K Sharma

Publications and source records attributed to S K Sharma.

At least 631 records · Page 35Linked to original sources
PubMed1978

The use of spleen antigen in the tube agglutination test for diagnosis of anaplasmosis in cattle.

An antigen was prepared from the spleen of an infected bovine calf and was used in the tube agglutination test. Cases having rare and very low parasitaemia as well as the carrier cases were detected by this procedure and no non-specific reaction was observed with other haemoprotozoan infections. The maximum titre obtained with the Anplasma positive sera was 1:20, about 60 per cent showed a titre of 1:10 and 90 per cent showed a titre of 1:5 or more. The test provided satisfactory results in detecting the cases even at the early phase of the infection. The test also proved useful in judging the efficacy of a drug employed to destroy the carrier status.

Agglutination Tests↗
PubMed1978

Subdural haematoma and the malfunctioning shunt.

Of 30 consecutive children with hydrocephalus treated by shunt implant, six developed subdural haematoma. Four of them presented with a malfunctioning shunt, and the diagnoses in all six cases were made by CT scan.

Cerebrospinal Fluid Shunts↗
PubMed1977

Opiate-dependent modulation of adenylate cyclase.

Reactions mediated by the opiate receptors that inhibit adenylate cyclase (EC 4.6.1.1) are closely coupled to subsequent reactions that gradually increase adenylate cyclase activity of neuroblastoma X glioma NG108-15 hybrid cells. Opiate-treated cells have higher basal-, prostaglandin E1-, and 2-chloroadenosine-stimulated activities than do control cells. However, NaF or guanosine 5'-(beta, gamma-imido)triphosphate abolishes most of the differences in adenylate cyclase activity observed with homogenates from control and opiate-treated cells. Cycloheximide blocked some, but not all, of the opiate-dependent increase in adenylate cyclase activity. These results suggest that the opiate-dependent increase in adenylate cyclase is due to conversion of adenylate cyclase to a form with altered activity. Protein synthesis also is required for part of the opiate effect. We propose that activity of adenylate cyclase determines the rate of conversion of the enzyme from one form to the other and that opiates, by inhibiting adenylate cyclase, alter the relative abundance of low- and high-activity forms of the enzyme.

Adenosine↗
PubMed1977

Application of various chemotherapeutic agents in experimental bovine anaplasmosis.

A trial was conducted with several chemotherapeutic agents against clinical and carrier cases of experimental bovine anaplasmosis. Dithiosemicarbazone (in combination with oxytetracycline). Chloramphenicol and Rolitetracycline proved to be very efficacious in bringing about the clinical recovery and the elimination of the carrier status. Treatment with Imidocarb caused a clinical recovery but could not completely eliminate the organisms.

Anaplasmosis↗