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Biomedical subjects

S K Mehta

Publications and source records attributed to S K Mehta.

At least 163 records · Page 9Linked to original sources
PubMed1987

Jejunal interposition hepaticoduodenostomy for choledochal cyst.

Four cases of choledochal cyst with interesting modes of presentation were managed by excision of the cyst and biliary drainage by a new physiological and antireflux technique of jejunal loop interposition hepaticoduodenostomy. The advantages of this new technique over earlier practiced procedures are discussed.

Adolescent↗
PubMed1986

Relative tachycardia in ambulant children with borderline hypertension.

Borderline hypertensives who demonstrate tachycardia have a tendency toward the development of essential hypertension. However, the documentation of tachycardia in previous studies has been generally based on brief periods of observation. In the present study, we measured heart rates through a 24-hour period in 16 ambulatory mildly hypertensive subjects (ages 5 to 23 years). When compared with normal matched controls, significantly (p less than 0.05) higher heart rates were observed during the waking periods (99 +/- 9 vs 90 +/- 11) and sleep periods (72 +/- 12 vs 62 +/- 7). Similar observations were also made for 24 hours (90 +/- 8 vs 79 +/- 8). In addition, hypertensives also demonstrated thickened (during diastole) left ventricular posterior wall (0.96 +/- 0.17 vs 0.85 +/- 0.13 cm; p less than 0.05) and interventricular septum (0.98 +/- 0.17 vs 0.84 +/- 0.19 cm; p less than 0.05). It is suggested that tachycardia may be an early manifestation of borderline hypertension in children.

Adolescent↗
PubMed1986

Thrombosis and infection complicating central venous catheterization in neonates.

To determine the risk of complication associated with Broviac central venous catheterization in neonates, we reviewed the records of 107 infants who were catheterized an average of 5 weeks after birth and cared for in our neonatal intensive care unit. Forty-five of the 107 neonates (42%) had one or more catheter-related complications. Infants with complications had significantly lower birth weights and gestational age, longer duration of catheterization, and more repeat catheterizations than infants without complications. The mortality rate in infants with complications was not different than that of infants without complications. The most common complications were thrombosis (23 neonates) and infection (20 neonates). The birth weight and the number of catheterizations were the best predictors of the risk of complications as determined by multiple regression analysis. We conclude that the risk of complication associated with central venous catheterization is high in our population of predominantly premature neonates; that the risk of complication is increased in neonates weighing less than 1,000 g or requiring more than one catheter; and that despite the high complication rate central venous catheterization was not associated with increased mortality in this population.

Birth Weight↗
PubMed1986

Specific circulating immune complexes in amoebic liver abscess.

A micro enzyme-linked immunosorbent assay was used to detect the presence of amoebic antigen in polyethylene-glycol-precipitated circulating immune complexes (CIC). A cutoff dilution of greater than 1:160 for the precipitates was taken to be of clinical significance. Among the patients with amoebic liver abscess, 93% (14 of 15 confirmed cases) had indications of amoebic antigen in CIC. In 57% of the suspected cases of amoebic liver abscess, amoebic antigen could be detected in CIC. The specificity of the technique for the demonstration of specific amoebic antigen is indicated by the undetectable levels of amoebic antigen in CIC in serum samples from nine cases of nonamoebic hepatic diseases and 10 apparently healthy subjects. It is thus believed that the specific diagnosis of an individual case of amoebic liver abscess can be made by demonstrating specific amoebic antigen in CIC.

Antibodies↗
PubMed1986

Formaldehyde-induced corrosive gastric cicatrization: case report.

A patient with poisoning due to formaldehyde ingestion is described. Endoscopy showed severe oesophageal burns and moderate gastric injury. Four weeks later endoscopy and barium examination revealed a normal oesophagus while the distal part of stomach was cicatrized.

Adult↗
PubMed1985

The lowering of daytime blood pressures with a single daily dose of acebutolol in ambulant hypertensives.

Intra-arterial blood pressure recordings were studied in 10 ambulant subjects with essential hypertension to evaluate the effect of a single daily dose of acebutolol. Blood pressures and heart rates, measured on a beat-to-beat basis were averaged over every hour, for the daytime, night-time, and for the total 24 hours. Acebutolol significantly lowered the average daytime systolic pressure (160 to 142 mmHg, p = less than 0.01), diastolic pressure (78 to 66 mmHg, p = less than 0.01), and the heart rate (92 to 77 beats/min, p = less than 0.001). Significantly lower pressures were demonstrated up to 11 hours after the last dose of acebutolol. The effect on heart rate lasted up to 13 hours. The observed lowering of pressures and heart rate during the remaining 11 hours did not reach statistical significance.

Acebutolol↗
PubMed1985

An index of peripheral vascular resistance.

An index of peripheral vascular resistance, derived from directly measured arterial pressure, has been developed and tested in an animal model. Assuming a mono-exponential character for diastole, the time constant for direct arterial pressure decay in the central aorta was obtained with high-fidelity recording techniques from six anaesthetized dogs. Changes in peripheral resistance were induced by infusion of phenylephrine or nitroprusside. The time constant correlated well with resistance determined from 1-min averages of pressure divided by integrated electromagnetic flow (r = 0.845). A portable system used for direct arterial pressure recording in ambulant outpatients yielded a mean correlation of 0.822 with resistance. In a study of patients undergoing cardiac catheterization, a time constant obtained from the brachial artery (the site of pressure recording in the ambulant subjects) correlated well with the aortic time constant (n = 6, r = 0.964). The results of the present work suggest that the time constant derived from direct arterial pressure waveform may be a useful index in the evaluation of the peripheral vascular resistance. Furthermore, with the help of the portable system it might be used for the continuous monitoring of resistance changes in ambulatory subjects.

Animals↗