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Biomedical subjects

S K Carter

Publications and source records attributed to S K Carter.

At least 91 records · Page 5Linked to original sources
PubMed1979

The dilemma of estrogen receptors and the response rate to cytotoxic chemotherapy. A problem of comparability analysis.

The question of whether estrogen receptor assay predicts for chemotherapy response and, if so, how, is currently controversial. Two papers have recently appeared with widely differing results. Both papers use retrospective analysis and are so heterogeneous as regards assay criteria for positivity, prognostic variable and drugs used that they cannot in truth be meaningfully compared. Resolution of the question will probably have to await prospectively designed trials.

Antineoplastic Agents↗
PubMed1978

Management of trials in the development of cancer chemotherapy.

Potential anti-cancer agents have classically undergone clinical assessment in Phase I, II and III trials. This paper examines the role of these trials and pre-clinical studies in the light of improving cancer chemotherapy. Many patients must now be treated with standard therapy before investigational drugs can be ethically used. The introduction of combined modality trials will require a very prolonged follow-up to demonstrate improved survival and recognize late onset of chronic toxicity.

Animals↗
PubMed1978

Importance of controlling the regional draining lymph nodes in breast cancer.

A major issue in the treatment of breast cancer deals with local control of disease and the necessity for removing microscopically involved lymph nodes. Many radiation oncologists are looking to the parasternal lymphatics as possible renewed justification for postoperative radiation. It is concluded that prospectively designed studies are needed to assay the importance of the internal mammary nodes and their adequate control. Lymphoscintigraphy may offer a method of evaluating these nodes without radical surgery.

Axilla↗