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Biomedical subjects

S Jenkins

Publications and source records attributed to S Jenkins.

At least 145 records · Page 8Linked to original sources
PubMed1979

Interaction of pneumococcal antigens with complement in rats.

Complement activation with pneumococcal antigens was studied both in vitro and after injection of the antigens into rats. Whole pneumococci of various serotypes activated C3-C9 in rat serum treated with ethyleneglycol-bis (beta-aminoethyl ether)-N,N'-tetraacetic acid, although serotypes differed greatly in the extent of activation. Some purified pneumococcal capsular polysaccharides also activated C3-C9 in rat serum, but only when the antigens were present in concentrations of 500 to 1,000 mug/ml. Much of the activation with capsular polysaccharides was eliminated by the use of ethyleneglycol-bis (beta-aminoethyl ether)-N,N'-tetraacetic acid. Activation of C3-C9 by capsular polysaccharides did not correlate with the level of reactivity observed with whole organisms of the same serotypes. After injection of 5 x 10(9) pneumococci (type 3 or type 4) intravenously into rats, there was a transient decline in serum C3-C9 activity, but there was no decline in C3-C9 levels after intravenous injection of 1,000 mug of type 3 or type 4 capsular polysaccharides. As determined by immunofluorescence, circulating capsular polysaccharide was deposited in several tissues, including the vascular endothelium and glomerular mesangium of the kidney. C3 was not detectable in these deposits, and there was no histological evidence of an inflammatory response. Capsular polysaccharides appear to be only weak activators of complement. Other pneumococcal antigens may be more important in the pathogenesis of hypocomplementemia in pneumococcal infection.

Animals↗
PubMed1978

Diagnostic delay in neoplastic disease.

It may be possible to measure quality of care in general practice by selecting a single criterion of care such as the delay in the recognition of neoplastic disease. Seven general practitioners reported on 55 new cases and the results are analysed according to age, sex, and diagnostic category. An attempt is made to quantify ;quality' by comparing the theoretical ;ideal' delay (retrospectively assessed) with the ;actual' delay. The wider implications of the study are discussed.

Adolescent↗
PubMed1977

Left ventricular endomyocardial biopsy. III: ultrastructural characteristics of cardiomyopathy and cardiac hypertrophy with good or poor ventricular function.

Left ventricular endomyocardial biopsies have been obtained from patients with cardiomyopathy and hypertrophy due to aortic valve disease. These biopsies have been examined by electron microscopy and the ultrastructural abnormalities compared. In congestive cardiomyopathy no specific abnormalities were found although myofibrillary degeneration and membrane-bound vacuoles were more commonly present. Crossing of whole groups of sarcomeres was found only in asymmetric septal hypertrophy, but was not present in all cases. Amyloid deposits were demonstrated easily by electron microscopy in patients with restrictive cardiomyopathy. In the patients with hypertrophy due to aortic valve disease, no specific features were found and ultrastructural abnormalities did not differentiate between normal and impaired left ventricular functions.

Aortic Stenosis, Subvalvular↗
PubMedDate not supplied

Dose and dose rate effects of beta-particle emitting radioactive stents in a porcine model of restenosis.

BACKGROUND: Radioactive stents have been proposed as a means to prevent in-stent restenosis by inhibiting intimal proliferation with continuous low-dose irradiation. OBJECTIVES: The purpose of this study is to determine the effects of cumulative dose and dose-rate delivery on neointimal formation using 32P and 90Y beta-particle emitting radioactive stents in a porcine coronary model of restenosis. METHODS AND MATERIALS: We compared the late histologic results of 0.25 to 32.0 microCi 90Y (half-life 64 hours) (n = 64 stents) and 0.1 to 57.6 microCi 32P (half-life 14.3 days) (n = 55 stents) Beta-particle emitting radioactive stents with non-radioactive (n = 40) stents in a porcine coronary model of restenosis. A computer-based dosimetry modeling program was used to determine the 28 day cumulative dose and dose-rate delivery for the beta-particle emitting radioactive stents at a distance of 0.1 mm from the stent surface. RESULTS: Continuous low dose-rate (1 to 5 cGy/hr) radiation delivery for > 2 weeks via a 0.1 to 0.5 microCi 32P radioactive stent effectively reduced in-stent neointimal hyperplasia at 90 days. Cumulative doses of > 55 Gy induced severe adventitial fibrosis, microvascular damage and promoted the formation of a matrix-rich neointima. Delayed vascular repair was evident at focal regions within the body of radioactive stents that delivered cumulative doses of > or = 140 Gy at 28 days and cumulative doses of 1,100 Gy at 90 days. CONCLUSIONS: These data may be useful in predicting safe and effective dose and dose rate delivery for beta-particle emitting radioactive stents.

Animals↗
PubMedDate not supplied

Community influences on breast feeding.

The incidence of breast feeding in Camden and Paddington is reported for two periods, 1974-75 and 1976-77. In 1976 a programme was begun to encourage breast feeding by increasing contact and support by the health visitor and child health visitor and child health clinic antenatally and postnatally. Fifty-eight per cent of mothers in Camden and 56% of mothers in Paddington breast fed at 3 weeks in 1976-77 compared with 24% (Camden) and 20% (Paddington) in 1974-75. The incidence of breast feeding in the experimental areas was compared with that in a similar control area in which no intervention occurred to investigate whether this increase reflected a widespread increase in the popularity of breast feeding or resulted from intervention. In 1976-77 more mothers in the experimental, than in the control area who breast fed on discharge continued to do so during the first 5 months. Of the mothers who were discharged breast feeding 88% in Camden and 73% in Paddington compared with 57% in the control area were still doing so at 6 weeks. The pattern of home visiting by the health visitors and attendance at the child health clinic was also investigated. More antenatal and postnatal home visits, more clinic visits and earlier home visits took place in the experimental areas compared with the control area. We conclude that the health visitor and child health clinic have an important role to play in the management of lactation.

Breast Feeding↗
PubMedDate not supplied

Health and behaviour in preschool children.

This study reviews the relationship between the health and behaviour of 870 preschool children reviewed over a 5-year period. Detailed information was collected at regular intervals on rates of upper and lower respiratory tract infections, ear infections, and other illnesses. The children were examined, and their behaviour was assessed using questionnaires. In addition, the mothers of the children were interviewed, and assessment was made of levels of maternal stress. Relationships are demonstrated between episodes of illness and different behaviour problems. Night waking, poor appetite, temper tantrums, difficulty in management, and the doctor's and mother's overall assessment of behaviour were all found to be correlated with recurrent minor illnesses. Relationships were also found between maternal stress and some of the behaviour variables. Attention is drawn to the well known association of stress with physical illness, and the importance of this relationship in the management of both infections and behaviour problems in the young child is discussed.

Anorexia↗
PubMedDate not supplied

Assessment of the reliability of school nurse height measurements in an inner-city population. (The Hackney Growth Initiative).

To establish the reliability of school nurses given training in height measurement we conducted an intra- and inter-individual reliability study under field conditions. The measurements of 7 school nurses were compared with those of a trained auxologist. The pooled standard deviation of the differences between repeat measurements for the school nurses (0.32 cm) compared favourably with that of the auxologist (0.35 cm). Height measurements made by school nurses were accurate within the range of -0.53 cm to +0.64 cm when compared with the auxologist. We conclude that a single, accurate height measurement made by a school nurse would be sufficiently reliable for use in routine screening for short stature.

Anthropometry↗
PubMedDate not supplied

Comparison of school nurse and auxologist height velocity measurements in school children with short stature. (The Hackney Growth Initiative).

To examine the possible use of height velocity (HV) as a growth screening tool, annual HV data calculated from height measurements made by school nurses were compared with those based on an auxologist's measurements in 20 short school children. The subjects were 12 primary school children (seven girls, five boys) with a mean (+/- SD) age of 5.9(0.6) years and eight secondary school children (six girls, two boys) with a mean (+/- SD) age of 11.8 (0.4) years. Heights were measured by the school nurses, separated by an interval of 1 year. Mean HV of the primary school children when assessed by school nurses was 5.92 cm/year compared with 5.97 cm/year when assessed by the auxologist. Mean (+/- SD) HV standard deviation score (HVSDS) was 0.03 (0.97) and 0.10 (1.15) respectively. Mean HV of the secondary school children when assessed by school nurses was 6.04 cm/year compared with 5.63 cm/year when assessed by the auxologist. Mean (+/- SD) HVSDS was -0.8 (2.1) and -1.21 (1.54) respectively. Of eight children (three primary, five secondary) identified by the auxologist as having HV < 25th centile of Tanner and Whitehouse standards only four were identified by school nurses (one primary, three secondary). One child identified by school nurses to have HV < 25th centile was found by the auxologist to be above the 25th centile. We conclude that HV assessment may fail to identify significant pathology in the community and that accurate height measurement rather than HV should be the principal referral criterion.

Anthropometry↗
PubMedDate not supplied

The nephrotic syndrome at presentation of insulin-dependent diabetes mellitus; cause or coincidence?

Two young women developed the nephrotic syndrome within 2 weeks of presenting with diabetes and starting insulin. One had a renal biopsy which showed changes consistent with 'minimal change nephrotic syndrome' on electron microscopy but no evidence of diabetic glomerulosclerosis. Neither patient received steroids; in one the oedema resolved spontaneously but the other required diuretics. This patient also had severe IgA-deficiency probably associated with epilepsy and/or phenytoin therapy and unrelated to the pathogenesis of the nephrotic syndrome. The nephrotic syndrome may rarely present coincidentally with, or soon after, insulin-dependent diabetes mellitus (IDDM). It must be distinguished from 'insulin oedema' and classical diabetic nephropathy which occurs later in the course of IDDM. All reported cases have either remitted spontaneously or responded to steroids.

Adolescent↗
PubMedDate not supplied

Emerging zoonoses.

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Animals↗