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Biomedical subjects

S Jankowski

Publications and source records attributed to S Jankowski.

At least 55 records · Page 3Linked to original sources
PubMed1991

Impaired bactericidal activity of serum of a child suffering from focal proliferative glomerulonephritis.

The serum of a child with focal proliferative glomerulonephritis was found to exhibit a weaker bactericidal activity against Pseudomonas aeruginosa, Salmonella typhimurium, Salmonella enteritidis and Escherichia coli strains as compared with sera of the child's parents. The child's serum showed a low haemolytical activity of complement as well as a low C3 concentration. The authors believe that the abnormal complement concentration could cause the impaired bactericidal activity of the patient serum.

Blood Bactericidal Activity↗
PubMed1990

Preliminary studies of the effect of ozone on the bactericidal properties of complement.

The study analyzes the bactericidal influence of an ozonized blood serum on gram-negative bacilli. Considerable differences were observed concerning the effect which ozonized normal human serum has upon Klebsiella, Pseudomonas and Salmonella strains. It was found that the impact may vary depending not only on the time of the exposure of serum to ozone, but also on the type of strain and the structure of the outer membrane of the bacteria. The Salmonella typhimurium strain of the Ra chemotype treated with the serum which was exposed to ozone showed higher susceptibility to the action of complement than the S. typhimurium strain of the S chemotype.

Blood Bactericidal Activity↗
PubMed1990

Sensitivity of Shigella strains to bactericidal activity of human serum. I. Participation of two independently active mechanisms in bactericidal action against Shigella sonnei phase II.

Normal human serum is strongly bactericidal for all studied Shigella sonnei phase II (10 strains). The studied bacteria were sensitive to two alternative mechanisms of the bactericidal activity of serum factors. The first mechanism involves the action of serum in which complement (C) is activated by the studied bacteria via the classical pathway. Lysozyme did not participate in this reaction. The second mechanism involves the combined action of two factors: C activated via the alternative pathway and lysozyme.

Blood Bactericidal Activity↗
PubMed1990

Sensitivity of Shigella strains to the bactericidal activity of human serum. II. Shigella flexneri 3 a is killed by complement activated via the classical pathway, with participation of lysozyme.

Normal human serum is bactericidal for all studied strains (15) of Shigella flexneri serotype 3a. The activity of the serum was similar irrespective of the invasiveness of the bacteria or its lack. The studied bacteria were susceptible to a single mechanism of bactericidal activity involving complement activated via the classical pathway, accompanied by the action of lysozyme.

Blood Bactericidal Activity↗
PubMed1988

Bactericidal activity of human sera with a physiologic or genetic defect of the complement system.

The serum of patient suffering genetically conditioned C2 defect showed a weak bactericidal activity against Pseudomonas aeruginosa strains. Out of 23 tested strains one was susceptible comparing with 16 ones sensitive to normal human serum. The normal cord serum exerted a bactericidal effect on 8 strains. All sera were found to be active against Salmonella strains tested.

Blood Bactericidal Activity↗
PubMed1987

Influence of plasmids on bacterial susceptibility to the bactericidal activity of sera. I. Characteristic of R plasmids of enteropathogenic strains of Escherichia coli isolated from clinical cases.

The 47 enteropathogenic Escherichia coli strains isolated from the cases of infant diarrhoea were characterized from the point of view of antigenic structures and drug resistance. Six R plasmids were obtained from these strains and were tested for protective activity of E. coli K12 W 1485 against lethal action of sera. Out of three sera tested, the investigated plasmids showed the most evident protective activity upon lethal action of neonatal serum. One of the plasmids appeared even more efficient than R100.1.

Animals↗
PubMed1987

Influence of plasmids on bacterial susceptibility to the bactericidal activity of sera. II. Relation between transfer frequency of R plasmids and their protective activity to the lethal effect of normal rabbit serum.

The plasmid pAM-Ia separated from the aggregate R588 protected E. coli K12 cells from the bactericidal action of normal rabbit serum much stronger when carried alone than in the aggregate. When aggregated with R100.1, its protective effect was also weakened. These decreases in protective effect are correlated qualitatively with inhibition of conjugational fertility. On the other hand the plasmid aggregate causing increase in protective activity showed no influence on their fertility.

Animals↗
PubMed1987

Influence of interactions between plasmids R. Vir and antigen K31 on the susceptibility of Escherichia coli strains to the normal rabbit serum.

K31 antigen is the important element of outer membrane in resistance of E. coli H209 to the bactericidal activity of normal rabbit serum. The strains more resistant to the effect of serum are those containing simultaneously K31 and other factors, R plasmids (like R100. 1 and pAM588-Ia) or virulence plasmids (Vir). Mutant strains lacking of K31 antigen are strongly killed by the serum but this effect is delayed when these strains had one of the above plasmids.

Animals↗
PubMed1985

Increase in the susceptibility of Salmonella strains to bactericidal activity of cord serum following treatment with agents disturbing surface structures.

Salmonella strains resistant to normal cord serum were found to become susceptible to it when the outer membrane was damaged by colistin, adult normal serum or Tris-HCl buffer. The present results indicate that after such treatment cord sera exert bactericidal effect, despite significant deficiencies in factors playing an essential role in this process.

Blood Bactericidal Activity↗
PubMed1983

Impaired bactericidal activity of cord sera against Salmonella strains.

Weaker bactericidal activity of cord sera against Salmonella bacilli was shown in comparison with maternal venous sera. No correlation was found between the bactericidal activity and the levels of complement, immunoglobulins and lysozyme in cord sera. Worthy of notice is detected in these researches specificity of bactericidal action of cord sera.

Blood Bactericidal Activity↗
PubMed1975

Observations on the serologic changes in the recombinants in Shigella flexneri Serotype 4a.

Studies on the antigenic composition of 84 diagnostic strains of S. flexneri serotype 4a and their Lac+ recombinants from a cross with E. coli HfrC were carried out. Considerable differentiation of agglutination reaction was found both in original material and in recombinants. An interesting group included recombinants which completely lost their capability to agglutinate with sera specific for type and group antigens and preserved only the capability to agglutinate in the polyvalent serum of S. flexneri subgroup. One of them (recombinant 140 Lac+) had been subject to detailed serological analysis and was shown to acquire as a result of recombination a new antigen appearing neither in any flexneri subgroup serotype, nor in dysenteriae and boydii subgroups. This antigen is of thermostable character.

Agglutination Tests↗