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Biomedical subjects

S Inoue

Publications and source records attributed to S Inoue.

At least 1,603 records · Page 89Linked to original sources
PubMed1979

Efficacy of acycloguanosine against herpetic ulcers in rabbit cornea.

The effect of a new antiherpetic compound of very low toxicity called acycloguanosine (Wellcome 248U) on herpetic ulcers in rabbit cornea was studied by the Corneal Epithelial Lesion Therapeutic Assay (CELTA). The therapeutic effect of 3% acycloguanosine ointment on dendritic ulcers was equal to that of 0.5% 5-iodo-2'-deoxyuridine (IDU) ointment. No toxic symptoms could be detected by slit-lamp on 4 days' treatment with this concentration of acycloguanosine. Because of its selective action on virus only, its extremely low toxicity in animals, and its availability for systemic administration, acycloguanosine seems to be an ideal antiviral compound for use in the treatment not only of herpetic keratitis but also of other herpetic diseases in man.

Animals↗
PubMed1979

Psychosomatic studies of allergic disorders.

It is generally conceded that allergic disorders occur in individuals who have a hereditary or congenital allergic constitution. Clinical symptoms of allergic disorders, however, often disappear due to changes of the individuals' life situations and/or their adaptive patterns. In a comparative study of allergic predisposition in students with allergic disorder (asthmatics) and students who had become completely free from childhood asthma for more than 3 years, without specific treatment, there was no significant difference in allergic predisposition between the two groups. The same tendency was also found between adult patients with allergic disorder (asthmatics) and persons who had shown complete remission for more than 3 years, having had psychosomatic treatment. These findings suggest that allergic predisposition does not influence the prognosis of allergic disorders as much as do socio-psychological factors. It is thought that the effect of psychosomatic treatment reconditions these socio-psychological factors which disturb homeostatic balance and which facilitate the clinical manifestation based on the allergic predisposition.

Adult↗
PubMed1979

Trophic effect of tetragastrin on the stomach, duodenum and pancreas in rats.

Subcutaneous injections of a large dose of tetragastrin (2 mg/day) into a rat for 4 weeks caused hypertrophy of parietal cells of the stomach, intestinal glandular cells of the duodenum, and pancreatic acinar cells. Ths histometrical analysis revealed that these trophic effects of tetragastrin were produced in varying degrees in different sites.

Animals↗