Biomedical subjects

S Huber

Publications and source records attributed to S Huber.

129 records · Page 8Linked to original sources

PubMedDate not supplied

The application of fibrin glue after axillary lymphadenectomy in the surgical treatment of human breast cancer.

Experimental studies point out that a reduction of lymph flow can be obtained by the local application of fibrin glue following axillary lymphadenectomy in the surgical treatment of breast cancer. In a prospective study the influence of human fibrin glue on postoperative axillary lymph secretion and the period of drainage of the wound cavity were evaluated. In 40 patients, 5 ml of fibrin glue (Tissucol) was applied to the wound cavity by the use of a spray applicator (Tissumat) immediately after axillary dissection of the lymph nodes. For drainage of the wound area Redon suction-drains were used. The daily amount of postoperative lymph secretion was measured and drains were removed at a lymph secretion of less than 20 ml. 40 patients who underwent surgery and axillary lymphadenectomy without subsequent application of fibrin glue sourced as control group. No significant difference concerning the total amount of lymph secretion, the mean period of drainage or the incidence of lymphatic cysts was observed. In our study, the expected occlusion of the wound cavity by the application of fibrin glue after axillary lymphadenectomy did not lead to any advantage when compared with the control group.

Adult↗

PubMedDate not supplied

Doppler ultrasound in the diagnosis of breast lesions.

This article reviews the current status of Doppler sonography in breast neoplasms. The results already reported in the literature all indicate that more vessels are displayed and higher flow velocities are measured in malignant tumors than in benign conditions. The potential role of Doppler sonography remains to be definitively determined. It appears that high measured flow velocities and markedly elevated number of detectable vessel density indicate malignancy. However, Doppler sonography does not make it possible to rule out cancer, since a subset of malignant tumors show few Doppler signals or none at all. The use of Doppler sonography for monitoring the results of treatment is currently being evaluated.

Breast Diseases↗

PubMedDate not supplied

Doppler sonography of breast tumours.

BACKGROUND: Doppler sonography has been used in breast tumours mainly for differential diagnostic purposes. Since angiogenesis appears to be related to the patient's prognosis, Doppler sonography may also have prognostic implications. CURRENT STATUS: CW Doppler was initially used, but is now obsolete. Contemporary studies are carried out using colour Doppler. Quantification of colour Doppler is not available on ultrasound platforms, but has been developed for off-line analysis by several investigators. Vascular density and flow velocities are found to be higher in malignant than in benign tumours. However, in some malignant lesions, flow may be undetectable. Though the actual role of the method in differential diagnosis is still controversial, it may improve diagnostic confidence when performed by an experienced examiner. PERSPECTIVES: Future fields of application currently being explored include monitoring of preoperative chemotherapy and prognostic assessment. Developments in the field of contrast media and scanner technology may further improve the quantitative estimation of tumour blood flow.

Breast Neoplasms↗