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Biomedical subjects

S Hirose

Publications and source records attributed to S Hirose.

At least 613 records · Page 34Linked to original sources
PubMed1987

Radionuclide cardiac monitoring system using dual cadmium telluride (CdTe) detectors: specification and some clinical applications.

The construction, physical characteristics, software and some clinical applications of a computerized dual cadmium telluride (CdTe) detectors system for continuous cardiac monitoring are described. The detectors and collimators are small, light and convenient for attachment to the chest wall. Data can be collected at 0.05 s intervals and for up to 3 h. Clinical studies in 33 patients using a prototype system demonstrated reasonably good correlation with left ventricular ejection fractions determined by a scintillation camera-computer system (r = 0.928). The application of this system to continuous monitoring of left ventricular function during exercise or drug stimulations has been found to be clinically useful.

Adult↗
PubMed1987

Visualization of ANP receptor on glomeruli of bovine kidney by use of a specific antiserum.

Atrial natriuretic peptide (ANP) receptor was purified from the bovine lung by affinity chromatography and preparative gel electrophoresis. A specific antiserum was raised against the purified receptor and used to localize receptors immunohistochemically on bovine kidney sections. Intense staining was seen in glomeruli. This distribution corresponds to that of ANP binding sites revealed by previous autoradiographic analyses and matches a glomerular action of ANP suggested by physiological studies.

Animals↗
PubMed1987

Relationship between maturation of the skin and electrical skin resistance.

In 16 newborn infants (24 6-39 wk 6 days 830-3390 g) at ages between 0-70 days, the skin's electrical resistance was measured. Over 30 min we sequentially measured direct current resistance between two skin electrodes placed on the abdomen. The resistance was found to be low in very premature infants with gestation ages of 30 wk or less. It increased with both gestational age and postnatal age. In these infants, the resistance measured at 30 min during the first 4 days of life (3.4 +/- 0.3 K omega; mean +/- SD) was significantly less than that found at 20-70 days (8.8 +/- 1.2 k omega; p less than 0.001). The relationship between the infant's electrical skin resistance (y) and the gestational age (x) best fit the exponential formula: y = 7.42 X e0.24x X 10(-4) + 2.74. This formula shows that the electrical skin resistance increases exponentially during the last trimester. The measurement of electrical skin resistance is a quantitative method that can be utilized to evaluate the gestational age of infants.

Galvanic Skin Response↗
PubMed1987

A case of atrial septal aneurysm in normal heart.

Atrial septal aneurysms are rare, usually associated with congenital heart disease causing atrial pressure elevation. We describe here a case of atrial septal aneurysm with no other cardiac abnormalities that was diagnosed by two-dimensional echocardiography.

Adult↗
PubMed1987

A case with pseudo-scimitar syndrome: "scimitar sign" with normal pulmonary venous drainage.

The case reported here showed a radiological appearance of hypoplasia of the right lung, dextroposition of the heart, and a curved vascular shadow in the right lower lung field known as a scimitar sign. However, a computed tomography of the chest showed this abnormal vascular shadow draining into the left atrium (pseudo-scimitar sign). Therefore, in patients with a radiological appearance of the scimitar syndrome, computed tomography of the chest should be indicated to rule out the pseudo-scimitar sign.

Cardiac Catheterization↗
PubMed1987

Immunoglobulin subclass antibodies to varicella-zoster virus.

Commercially available mouse monoclonal antibodies to human IgG subclass (IgG1 to IgG4) were applied to an enzyme-linked immunosorbent assay to measure IgG subclass-specific antibodies to varicella-zoster virus in children naturally infected with varicella-zoster virus and in varicella vaccine recipients. In children naturally infected with varicella-zoster virus, IgG 1 antibody was detected 2 weeks after onset of the disease in all cases, its activity increased at 1 month after onset, and almost equal antibody value was maintained 10 years after infection. This pattern of antibody response was similar to that of total IgG antibody to varicella-zoster virus after natural infection. On the other hand, low antibody activity was found in IgG2 only at 1 month of the disease. The highest antibody level of IgG3 was shown 2 weeks after onset of the disease; then, it gradually decreased, and no antibody activity was detected 10 years later. IgG4 antibody was first detected 1 month after onset and an almost equal level of antibody was shown 10 years after the disease. After inoculation of children with a live varicella vaccine, in contrast, IgG subclass antibody responses to vaccine recipients were almost equal to those after natural infection.

Antibodies, Viral↗
PubMed1987

Establishment of a new human B cell line carrying t(11;14) chromosome abnormality.

A new human cell line, SP-49, was established from the peripheral blood of a patient with leukemic conversion of diffuse lymphoma, medium-sized cell type. SP-49 cells were shown to have intracytoplasmic and surface immunoglobulin and Leu-12 antigen, but were negative for Epstein-Barr virus nuclear antigen. Chromosome analysis demonstrated that SP-49 had t(11;14) chromosome translocation involving 11q13 and 14q32, where oncogene bcl-1 and immunoglobulin heavy chain gene, respectively, were reportedly located.

B-Lymphocytes↗
PubMed1987

Genetic and cellular basis of anti-DNA antibody synthesis in systemic lupus erythematosus of New Zealand mice.

There is now ample evidence that multiple genes are involved in the pathogenesis of systemic lupus erythematosus (SLE) in New Zealand mice. However, it also became evident that SLE is a syndrome in which each autoimmune feature is separately controlled by a limited number of major genes although some common genes do play a role in different autoimmune features. The data obtained by genetic analyses of murine lupus are a most useful guide for studies on autoimmunity, as related to (1) the type or subset of immune cells expressing each autoimmune disease gene; (2) how each gene or the cell (in which the gene is activated) plays a role in the etiopathogenesis of the disease; and (3) how the gene actions can be manipulated. Data on aspects of the genetic and cellular basis of murine lupus, particularly as related to the anti-DNA antibody synthesis in the (NZB X NZW)F1 hybrid mice are presented based on studies done in our laboratories.

Animals↗