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Biomedical subjects

S Hillerup

Publications and source records attributed to S Hillerup.

At least 19 recordsLinked to original sources
PubMed2005

Nerve injury caused by mandibular block analgesia.

Fifty-four injection injuries in 52 patients were caused by mandibular block analgesia affecting the lingual nerve (n=42) and/or the inferior alveolar nerve (n=12). All patients were examined with a standardized test of neurosensory functions. The perception of the following stimuli was assessed: feather light touch, pinprick, sharp/dull discrimination, warm, cold, point location, brush stroke direction, 2-point discrimination and pain perception. Gustation was tested for recognition of sweet, salt, sour and bitter. Mandibular block analgesia causes lingual nerve injury more frequently than inferior alveolar nerve injury. All grades of loss of neurosensory and gustatory functions were found, and a range of persisting neurogenic malfunctions was reported. Subjective complaints and neurosensory function tests indicate that lingual nerve lesions are more incapacitating than inferior alveolar nerve lesions. Unlike most mechanical injuries after surgery, injection injuries were not followed by a course of spontaneous improvement of neurosensory and/or gustatory function. This may indicate neurotoxicity as a central aetiological factor. Fifty-four percent of the nerve injuries were associated with Articaine 4%, and a substantial increase in the number of injection injuries followed its introduction to the Danish market.

Adult↗
PubMed1998

Analgesic dose-response relationship of ibuprofen 50, 100, 200, and 400 mg after surgical removal of third molars: a single-dose, randomized, placebo-controlled, and double-blind study of 304 patients.

The purpose of this single-dose, randomized, placebo-controlled, and double-blind study was to evaluate the analgesic dose-response relationship of 50-mg, 100-mg, 200-mg, and 400-mg doses of ibuprofen after third molar surgery. Patients were instructed to take a single dose of either placebo or 50 mg, 100 mg, 200 mg, or 400 mg of ibuprofen when the postoperative pain was moderate to severe. Acetaminophen 500 mg was used as a rescue medication. Pain intensity, pain relief, and any possible adverse events were recorded on self-administered questionnaires hourly for 6 hours after intake of study medication. If rescue medication was taken, the time of intake was registered. A total of 304 patients entered the study, and 258 complied with the protocol. A positive analgesic dose-response relationship of 50-mg, 100-mg, 200-mg, and 400-mg doses of ibuprofen was observed when evaluated by pain intensity difference, sum of pain intensity difference, pain relief, total pain relief, and survival distribution of patients not taking rescue medication. Although significant pain relief was seen after a dose of 50 mg ibuprofen, ibuprofen 400 mg provided maximum pain relief and the longest duration of analgesic effect. Mild transient adverse events were reported by 6.8% of the patients. However, there was no significant difference in frequency between the placebo and 50 mg, 100 mg, 200 mg, and 400 mg ibuprofen dose groups.

Adult↗
PubMed1997

Computerized cephalometric evaluation of orthognathic surgical precision and stability in relation to maxillary superior repositioning combined with mandibular advancement or setback.

PURPOSE: A computerized, cephalometric, orthognathic surgical program (TIOPS) was applied in orthognathic surgical simulation, treatment planning, and postoperatively to assess precision and stability of bimaxillary orthognathic surgery. PATIENTS AND METHODS: Forty consecutive patients with dentofacial deformities requiring bimaxillary orthognathic surgery with maxillary superior repositioning combined with mandibular advancement or setback were included. All patients were managed with rigid internal fixation (RIF) of the maxilla and mandible and without maxillomandibular fixation (MMF). Preoperative cephalograms were analyzed and treatment plans produced by computerized surgical simulation. Planned, 5-week postoperative and 1-year postoperative maxillary and mandibular cephalometric-positions were compared. RESULTS: In the mandibular advancement group, the anterior maxilla was placed too far superiorly, with an inaccuracy of 0.4 mm. The posterior maxilla and the anterior mandible were placed in the planned positions. The lower posterior part of the mandibular ramus was placed too far anteriorly, with an inaccuracy of 2.0 mm. However, the mandibular condyles were accurately placed. In the setback group, the anterior maxilla was placed too far superiorly and posteriorly, with a vertical and sagittal inaccuracy of 1.0 mm and 0.7 mm, respectively. The posterior part of the maxilla was placed in a posterior position with an inaccuracy of 1.9 mm. The anterior mandible was placed too far anteriorly with an inaccuracy of 0.9 mm. The lower posterior part of the mandibular ramus was placed in a posterior position with an inaccuracy of 0.9 mm. However, the mandibular condyles were accurately placed. The statistical analysis of the 1-year stability data showed that the maxilla had moved 0.3 mm posteriorly in the advancement group and the lower incisors had moved 0.8 mm superiorly. No other significant positional maxillary or mandibular changes were found. In the setback group, the maxilla had moved 0.5 mm posteriorly, the anterior mandible 0.5 mm anteriorly, and the lower incisors 0.7 mm superiorly. No significant positional changes were seen in the mandibular ramus. CONCLUSION: The TIOPS computerized, cephalometric, orthognathic program is useful in orthognathic surgical simulation, planning, and prediction, and in postoperative evaluation of surgical precision and stability. The simulated treatment plan can be transferred to model surgery and finally to the orthognathic surgical procedures. The results show that this technique yields acceptable postoperative precision and stability.

Adolescent↗
PubMed1996

Non-submerged osseointegrated dental implants with ball attachments supporting overdentures in patients with mandibular alveolar ridge atrophy. A short-term follow-up.

Non-submerged, hollow screw ITI-Bonefit dental implants with ball attachments supporting overdentures were used as alternative treatment to combined vestibulo-lingual-plasty with free split-thickness skin graft and removable dentures in 40 consecutive patients with mandibular alveolar ridge atrophy. One hundred and fifty-six non-sub-merged fixtures were installed. Ball attachments were mounted on the fixtures and implant-supported overdentures inserted 3-4 months after fixture installation. The observation period after implant activation and prosthesis insertion varied from 1 to 3 years with a median observation period of 2 years. The overall success rate of individual implants was 99%(155/156). The prosthesis function rate was 100%(40/40). The 1-year success rate of individual implants was 99%(155/156) with a prosthesis function rate of 100%(40/40). No persistent surgical, periodontic or prosthodontic complications were observed. The results indicate that non-submerged osseointegrated ITI-Bonefit dental implants with ball attachments supporting overdentures can be a successful alternative to combined vestibulo-lingual-plasty with free split-thickness skin graft and removable dentures, and as successful as the use of submerged dental implants.

Aged↗
PubMed1994

Preprosthetic surgery in the elderly.

Preprosthetic surgery is an aspect of dentistry that has a close relationship to prosthodontics and oral and maxillofacial surgery. The main functions of preprosthetic surgery are elimination of pathology in the denture-bearing soft and hard tissues, and ridge improvement. Limited vestibuloplasty is still considered a predictable and cost-effective procedure for patients who are well adapted to removable dentures. The excellent documentation of osseointegrated implants as supportive and retentive devices for prostheses has reduced the need for major ridge-improving surgery. Many clinical conditions, especially in the maxilla, cannot be managed solely with implants. The combination of preprosthetic surgery and implants may solve problems that neither discipline can solve alone.

Aged↗
PubMed1994

Repair of the lingual nerve after iatrogenic injury: a follow-up study of return of sensation and taste.

PURPOSE: To evaluate the return of sensation and taste after surgical repair of the lingual nerve in patients who had experienced lingual nerve sectioning. PATIENTS AND METHODS: Average follow-up was 3.7 years with a range of 1.1 to 4.6 yrs. The patients' assessment of tongue sensation and taste was registered. Clinical testing for sensibility included light touch, prick, sharp/dull discrimination, heat (45 degrees C), cold (0 degree C), anterior/posterior localization of touch, perception of direction of touch movement, and two-point discrimination. The sense of taste was tested with sweet (saccharose 5%), sour (citric acid 5%), salt (saline 5%), and bitter (chinin-hydrochloride 0.5%). RESULTS: Three patients rated their tongue sensation on the affected side as normal, another three scored subnormal, and one felt no sensibility. Likewise, four patients thought that their sense of taste was normal, two were undecided, and one felt no sense of taste on the affected side. The ability to differentiate the quality of taste on the operated side of the tongue was validated in four of 24 tests. Conversely, on the healthy side of the tongue, two of 24 tests proved negative for taste perception. CONCLUSION: There was a notable difference in the patients' assessment of normality of tongue sensation versus the result of neurological testing. Likewise, there was a remarkable difference between the patients' subjective impression of gustatory capability and their ability to diagnose the quality of taste on testing.

Adolescent↗
PubMed1994

Precision of orthognathic surgery. A computerized cephalometric analysis of 27 patients.

The precision of orthognathic surgery was evaluated in 27 patients. Rigid internal skeletal fixation was used without intermaxillary fixation. A computerized cephalometric program package (TIOPS) was utilized in the preoperative analysis, surgical planning, and postoperative examination. The mean positional difference of the cephalometric landmarks between planned and observed outcome ranged from -0.4 to 0.7 mm. Only one reference point (pm) differed statistically significantly from the plan (P = 0.02). All other mean differences in point location were of a magnitude that was not statistically different from zero (P > 0.05). It was concluded that no systematic sources of error could be demonstrated. However, the range of random variation in the individual cases left room for considerable improvement.

Adult↗
PubMed1992

Computerized cephalometric orthognathic surgical simulation, prediction and postoperative evaluation of precision.

A new computerized, cephalometric, orthognathic surgical program (TIOPS) has been evaluated in surgical simulation, prediction and postoperative assessment of precision. Records of 10 consecutive patients admitted for orthognathic surgical treatment were analysed and prediction plans produced by computerized surgical simulation. Predicted and postoperative positions of maxilla and mandible were compared with linear and angular measurements. No statistically significant differences between predicted and postoperative positions could be demonstrated (p greater than 0.05).

Adolescent↗
PubMed1992

Does metronidazole prevent alveolitis sicca dolorosa? A double-blind, placebo-controlled clinical study.

The effect of a single preoperative dose of metronidazole in the prevention of alveolitis sicca dolorosa (ASD) after surgical removal of one impacted, non-infected mandibular third molar was investigated. A patient sample of 270 were given either 1000 mg of metronidazole or placebo at least 30 min before surgery. The preoperative recordings included gender, age, tooth to be removed, experience of surgeon, time of test medication, and duration of surgery. No difference was found between the metronidazole and placebo groups in the occurrence of ASD. The duration of surgery and the experience of the operating surgeons had no effect on the occurrence of ASD. The present study failed to demonstrate any preventive effect of a single dose of metronidazole on the development of ASD.

Adult↗
PubMed1990

Influence of skin graft pathology on residual ridge reduction after mandibular vestibuloplasty. A 5-year clinical and radiological follow-up study.

The present study is a 5-year clinical and radiographic follow-up of 51 patients who had undergone a combined vestibuloplasty with a split skin graft and lowering of the floor of the mouth. Our purpose was to examine the effect of clinically evident graft pathology on the residual ridge reduction. The clinical records of the graft condition were classified into: healthy graft, partial loss of keratinization, and total loss of keratinization. The residual ridge reduction was monitored by ridge height measurements at different locations, and by the symphyseal and mandibular body areas. Patients with clinical signs of graft pathology (reddening, loss of keratinization) suffered a significantly more severe residual ridge reduction than those with a healthy skin graft (p less than 0.01). Subsequent findings including smear tests showing Candida albicans hyphae, and improvement of graft condition after antimycotic therapy, indicated that the graft pathology observed is a candidiasis.

Adult↗
PubMed1990

Soft tissue profile changes after mandibular vestibuloplasty. A two-year follow-up study comparing the Edlan flap, mucosal and skin graft methods.

It is the aim of the present study to examine the pattern of postoperative changes in the soft tissue profile of 50 edentulous patients after 3 common types of mandibular vestibuloplasty, the Edlan flap operation (n = 15), the buccal mucosal graft (n = 19), and the skin graft vestibuloplasty (n = 16). The soft tissue profile changes were recorded on lateral cephalometric radiographs taken preoperatively, and after 1, 3, 6, 12, and 24 months post surgery. The 3 groups did not differ with respect to clinical features or presurgical cranio-facial morphology. Neither was any significant difference in postoperative profile changes found between the groups. The surgery gave rise, directly and indirectly, to a number of changes in the facial soft tissue profile many of which were interrelated. The chin thickness increased by 2.3 mm, and the lower lip height exhibited a reduction of 1.8 mm at 1 month after surgery as a direct consequence of the operation. After 3 months the profile changes were mostly associated with the reduction of the anterior face height (overclosure).

Adult↗
PubMed1989

Reduction of mandibular residual ridge after vestibuloplasty. A two-year follow-up study comparing the Edlan flap, mucosal and skin graft operations.

Mandibular residual ridge reduction (RRR) after Edlan flap vestibuloplasty, buccal mucosal graft, and split skin graft vestibuloplasty was measured on lateral cephalometric radiographs obtained 1, 3, 6, 12 and 24 months postsurgery in 50 patients. The ridge reduction was most severe during the immediate postoperative period. The different operation methods did not give rise to significant variations in the reduction pattern, neither did the sex of the patient appear to be an important factor. The temporary increase of mandibular resorption after vestibuloplasty surgery is of a magnitude comparable to the average RRR during 1 year in full denture wearers with a long denture experience.

Aged↗
PubMed1987

Preprosthetic mandibular vestibuloplasty with split-skin graft. A 2-year follow-up study.

17 patients with lower denture malfunction problems related to insufficient residual ridges had a vestibuloplasty with split-skin graft performed in the mandible under local analgesia on an out-patient basis. The patients were followed-up for 2 years and records of vestibular extension showed a maximum of relapse at the 1-month control (24%). Most of the lost extension was regained at the 6-month check, and the 2-year outcome was 92% of the surgically-created vestibular sulcus extension as a mean value of records obtained at the midline and canine regions. A comparison with a previous study on buccal mucosal graft vestibuloplasty led to the conclusion that free grafts of skin and buccal mucosa prevent a relapse equally well under the same circumstances. 13 patients were satisfied with the improvement achieved, 3 reported fair, and 1 was dissatisfied with the result of the operation. The split-skin graft underwent a change of appearance in 5 cases interpreted as a skin graft candidosis. Indication of this condition accelerating the residual ridge resorption is discussed.

Adult↗
PubMed1987

Tooth transplantation to bone graft in cleft alveolus.

Autotransplantation of teeth has developed from a last resort operation into a well tested and relatively predictable clinical procedure. This article documents four cases where autologous teeth were successfully transplanted into bone from the iliac crest grafted to an alveolar cleft. The possibility of tooth transplantation should be considered when planning dental rehabilitation for patients with cleft.

Adolescent↗