Search PubMed⌕ Search

Biomedical subjects

S Heyden

Publications and source records attributed to S Heyden.

At least 55 records · Page 3Linked to original sources
PubMed1984

Prospective study of "fibrocystic breast disease" and caffeine consumption.

Conflicting reports have appeared in the recent literature on a presumed association between coffee intake and "fibrocystic breast disease." The hypothesis suggesting that abstention from coffee and caffeine consumption eliminates breast pain and resolves breast nodules was based on an uncontrolled clinical study. For a condition with a notorious reputation for "waxing and waning," it is essential to document the stability versus instability of clinical findings, keeping the methyl xanthine consumption constant. Seventy-two women, all with palpable breast nodules, were followed over a 6-month period with monthly examinations and questionnaires on intake of coffee, tea, soft drinks, chocolate, candies, and caffeine-containing drugs. The methyl xanthine consumption remained remarkably constant throughout the observation time. The examiner was uninformed as to previous examination findings and pain reports of each woman. In 21 (15%) breasts with nodularity, the nodules had completely disappeared by the termination of the study. A total of 125 (87%) breasts of the sample manifested a change in the number of nodules or a change in position. Forty-eight of the 72 women were menopausal. For a chronic condition with so much variety of subjective sensitivity and great variability of objective clinical palpation, it is difficult to relate the amount of methyl xanthine consumption to "fibrocystic breast disease."

Adult↗
PubMed1984

Serum retinol and risk of subsequent cancer: extension of the Evans County, Georgia, study.

A previous report from the Evans County, Ga., cohort correlated low base-line retinol levels in 1960-62 to an increased risk of cancer developing in the following 12-14 years. So that this inverse association could be retested, retinol determinations were performed on sera in 135 incident cancer cases, identified during a vital status follow-up in 1981, and in 237 controls matched by race, sex, age, and date of venipuncture. The serum was drawn during the second cohort examination between 1967 and 1969 and stored at -20 degrees C until analysis by high-pressure liquid chromatography in January 1982. Eligible for the study were patients whose initial cancer diagnosis was established more than 24 months after venipuncture. Base-line retinol levels of subsequent cancer cases and their matched controls were similar in the 4 race-sex groups. The risk of cancer at all sites associated with the lowest retinol quintile was similar to that associated with the highest quintile. In multivariate analysis, with control for age, cholesterol, body mass, smoking status, and social class, no significant relationship of serum retinol and case status was found. In summary, these data fail to confirm the strong dose-response relationship between baseline retinol levels and subsequent cancer reported in the previous study.

Female↗
PubMed1982

Cholesterol controversy--where do we go from here? 'Toward healthful diets' reevaluated.

The document, entitled 'Toward Healthful Diets' that was developed by the Food and Nutrition Board of the National Academy of Sciences last year, has again stirred major controversy among the general public and in the medical community regarding the diet-heart hypothesis as a basis for efforts to favorably modify the natural history of atherosclerotic vascular disease in the American population. In this rebuttal to the conclusion drawn in 'Toward Healthful Diets', we review recent evidence in support of the diet-heart hypothesis. We conclude that continued efforts to reduce dietary cholesterol and saturated fat, in the context of efforts to eliminate other reversible risk factors as well, should remain an important goal for individuals and physicians seeking to limit premature death or disability fom atherosclerotic vascular disease.

Adolescent↗
PubMed1982

Lipoprotein and blood pressure changes during weight reduction at Duke's Dietary Rehabilitation Clinic.

The influence of a weight-reducing diet among 129 obese patients after only 4 weeks at Duke's Dietary Rehabilitation Clinic is evaluated in its effect on cholesterol, HDL and LDL cholesterol, and on hypertension in combination with and without drugs. The 700-cal diet consists of 60 g protein, 60 g carbohydrates and 25 g invisible fat. After 4 weeks, total cholesterol decreased on the average by 44 mg% and serum triglycerides by 65 mg%. While LDL cholesterol declined by 30 mg% and VLDL cholesterol by 10 mg%, HDL cholesterol showed a small decrease of 7 mg%. Blood pressure levels were normalized in the 63 hypertensive patients. The conclusion is that a very moderate weight loss of only 9-12 kg has profound influences on important risk factors.

Adult↗
PubMed1980

Risk of stroke in asymptomatic persons with cervical arterial bruits: a population study in Evans County, Georgia.

A survey of the rural community in Evans County, Georgia, revealed cervical arterial bruits in 72 (4.4 per cent) of 1620 persons 45 years of age of older without previous stroke, transient ischemic attacks, or overt ischemic heart disease. The prevalence of such asymptomatic bruits increased with age and was greater in women and persons with hypertension. We estimated the risk of stroke associated with cervical bruits during a six-year follow-up period, taking age and blood pressure into account. The presence of asymptomatic bruits was associated with a significantly higher risk of stroke in men but not in women, with odds ratios of 7.5 and 1.6, respectively. Despite the high risk of stroke among men with bruits, the correlation between the location of the bruits and the type of subsequent stroke was poor. Moreover, cervical bruits in men were a risk factor for death from ischemic heart disease. We suggest that asymptomatic cervical bruits are an indication of systemic vascular disease and do not themselves justify invasive diagnostic procedures or surgical correction of underlying extracranial arterial lesions.

Age Factors↗