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Biomedical subjects

S Hayasaka

Publications and source records attributed to S Hayasaka.

At least 163 records · Page 9Linked to original sources
PubMed1991

Polymorphonuclear leukocytes and bacterial growth of the normal and mildly inflamed conjunctiva.

We examined 304 conjunctiva in 152 subjects by clinical, cytologic, and bacteriologic methods. Bacteriologic samples were evaluated after a 48-hour incubation. Bacterial growth was found in 8 (20.5%) of 39 patients with clinically normal conjunctiva and no polymorphonuclear leukocytes (PMNs), and in 8 (61.5%) of 13 subjects with clinically normal conjunctiva and evidence of PMNs. Bacterial growth also was observed in 4 (40.0%) of 10 patients with clinically mild conjunctivitis and no PMNs, in 10 (24.4%) of 41 patients with clinically mild conjunctivitis and a mixture of inflammatory cells or predominantly lymphocytes, and in 37 (75.5%) of 49 patients with clinically mild conjunctivitis and evidence of PMNs. The presence of PMNs was well correlated with the existence of rapid-growing bacteria.

Adolescent↗
PubMed1991

Foster Kennedy syndrome and optociliary shunt vessels in a patient with an olfactory groove meningioma.

A 48-year-old woman complained of acute loss of vision in her right eye. Ophthalmoscopically, the right optic disk appeared pale, and abnormally dilated vessels were noted on the disk. The left optic disk was reddish and swollen. Fluorescein angiography revealed abnormal vessels on the right optic disk that might be venous. The patient had right-sided anosmia. Computed tomography and magnetic resonance imaging showed a lesion in the frontal lobe that was deviated to the right and attached to the olfactory groove. A histopathologic study of the excised specimen disclosed a meningioma. We believe that this patient with olfactory groove meningioma represents a rare case of Foster Kennedy syndrome and optociliary shunt vessels.

Ciliary Body↗
PubMed1991

Recurrent mixed tumor of the right lacrimal gland causes acute contralateral visual loss.

A 23-year-old woman underwent excisional biopsy of a right palpebral mass: the histopathologic study showed a benign mixed tumor of the lacrimal gland. Thereafter, the tumor recurred repeatedly, and multiple excisions were done. Subsequently, right orbital exenteration was performed, and some orbital and frontal bones were removed. When the patient was 52 years old, the orbital tumor recurred. A histopathologic study revealed malignant transformation. At the age of 54 years, the patient suffered acute loss of vision in her left eye. Computed tomography disclosed invasion of the tumor into the posterior paranasal sinuses and brain.

Adenoma↗
PubMed1991

Presumed iris metastasis from abdominal neuroblastoma.

A 2-month-old infant had a retroperitoneal tumor and increased levels of vanillylmandelic acid and homovanillic acid in the urine, indicating an abdominal neuroblastoma. Two whitish masses that were noted on the left iris regressed in synchrony with the primary tumor mass as therapy was administered. We believe that our patient represents the third reported case of iris metastasis from abdominal neuroblastoma.

Homovanillic Acid↗
PubMed1991

Ophthalmic complications in patients with paranasal sinus mucopyoceles.

We examined 45 (23 male and 22 female) Japanese patients with paranasal sinus mucopyoceles associated with ophthalmic complications. The patients ranged in age from 31 to 87 years. The patient distribution by the affected sinus was as follows: maxillary sinus alone, 17 patients; ethmoidal sinus alone, 9 patients; frontoethmoidal sinuses, 9 patients; frontal sinus alone, 7 patients, and other multiple sinuses, 3 patients. Thirty-nine mucoceles and 6 pyoceles were identified. Ophthalmic signs and symptoms included lid swelling, ocular pain, pseudoptosis, proptosis, displacement of the eyeball, epiphora, slight blurring of vision, severely decreased visual acuity, visual field abnormality, diplopia, disk edema, retinoichoroidal folds and increased intraocular pressure. Of the 45 patients, 1 had a history of sinus trauma and 29 had a history of sinus surgery.

Adult↗
PubMed1991

Orbital tumor in an infant with acute monocytic leukemia associated with chromosome 5q-,t(9p-11q+),11p+.

We examined an 8-month-old infant with left proptosis, chemosis and orbital mass. A computed tomographic scan revealed a left orbital tumor. An anorectal nodule was also found. Results of the hematologic study showed poorly differentiated acute monocytic leukemia (M5 according to the French-American-British classification). Chromosomal analysis disclosed 46, XX,5q-,t(9p-;11q+),11p+. We believe that our patient represents a rare case of orbital tumor in acute monocytic leukemia associated with chromosomal abnormalities.

Chromosome Aberrations↗
PubMed1991

Optic nerve hypoplasia associated with porencephalia in a girl and retinitis pigmentosa in her sister.

An 18-year-old women (case II-4) had decreased visual acuity, visual-field defects and small optic disks bilaterally that remained unchanged for a follow-up period of 9 years. The patient also had an abnormal cavity within the cerebral hemispheres. Her 29-year-old sister (case II-1) had night blindness, bone corpuscle pigmentation in mottled retinas and nonrecordable electroretinographic responses bilaterally. We believe that the occurrence of optic nerve hypoplasia associated with porencephalia in one patient and retinitis pigmentosa in her eldest sister may be rare.

Adolescent↗
PubMed1991

Parasitism of Toxocara canis larvae in Japanese quails by inoculation of the ascarid eggs.

The distribution of T. canis larvae and pathological changes caused by them were studied in Japanese quails orally inoculated with 1,500, 4,000 or 15,000 embryonated eggs. Larvae were distributed mainly in the liver and, to lesser extent, in the muscles, brain, eyes and other organs. The number of larvae varied from 7 to 3,346, and from 1 to 288 in the liver and muscles (breast and legs), respectively. A small number of larvae were also recovered from the heart, gizzard, brain and eyes. In the groups of quails inoculated with 4,000 or 15,000 eggs, small white foci were observed on the surface of the liver 6 or 12 hr after inoculation. Histopathological examinations revealed necrotic lesions, leukocytic infiltration, granuloma and nodular lesions. The pathological changes became more serious with the large size of inoculum and days after inoculation.

Animals↗
PubMed1991

[The significance of CA-50, SLX and ST-439 in lung cancer].

Serum levels of CA-50, SLX and ST-439 were measured in 213 patients with lung cancer (92 adenocarcinomas, 63 squamous cell carcinomas, 37 small cell carcinomas and 21 large cell carcinomas) and 87 patients with benign lung disease. The overall positive rates in patients with lung cancer were 12.8% for CA-50, 29.7% for SLX and 25.3% for ST-439. The positive rates for CA-50, SLX and ST-439 in adenocarcinoma patients were 22.8%, 42.4% and 38.0%, respectively. Of the patients with benign lung disease, 4.8% were false positive for CA-50, 15.3% for SLX and 3.6% for ST-439. In the patients with adenocarcinoma of the lung, the combination assay of CEA and ST-439 had a highly accurate rate (61.9%).

Adenocarcinoma↗
PubMed1991

Pigmented paravenous retinochoroidal atrophy in a 68-year-old man.

A 68-year-old man with patchy paravenous zones of retinal degeneration with bone spicule pigmentation OU was diagnosed as having pigmented paravenous retinochoroidal atrophy. We reviewed the literature and found 71 previously reported cases of this condition. Most of the affected individuals were young adults. By comparison, our patient was afflicted at a considerably older age.

Aged↗
PubMed1991

Effect of sodium chloride on pirarubicin induced cell killing in P388 mouse leukemia cells.

The effect of sodium chloride on the cytotoxicity of 4'-O-tetrahydropyranyldoxorubicin (pirarubicin), a novel anthracycline derivative, was investigated on P388 mouse leukemia cells in vitro. The modifications in efficiency of uptake and killing action of pirarubicin were found to be dependent on the ionic strength of the medium. The relationship between intracellular drug accumulation into cells and cell killing was pointed out.

Animals↗
PubMed1991

[Bronchoalveolar lavage studies in a HTLV-1-positive case associated with interstitial pneumonia].

A 64-year-old housewife was hospitalized because of cough and dyspnea. Chest X-rays on admission showed diffuse interstitial shadows and loss of lung volume, suggesting acute interstitial pneumonia. Pulmonary function tests revealed decreased vital capacity and severe hypoxemia. Bronchoalveolar lavage studies showed that total cell counts and a proportion of lymphocytes were increased. Lymphocytes increased in lavage fluid consisted mainly of T cells with an elevated CD4+/CD8+ ratio. Furthermore, these lymphocytes spontaneously proliferated and responded well to recombinant IL-2 when cultured in vitro for 5 days, suggesting that lymphocyte activation occurred in the lung. Such lavage findings and lymphocytes activation in association with the presence of HTLV-1-specific IgA antibody in lavage fluid have been demonstrated in patients with HTLV-1-associated myelopathy. In this patient positive for HTLV-1, however, it could not be determined whether the pulmonary lesions were primarily related to HTLV-1 infection, because no IgA antibody specific for HTLV-1 was demonstrated in lavage fluid. In conclusion, when pulmonary abnormalities are found in HTLV-1 carriers, we should be careful in determining whether such pulmonary involvements are etiologically related to HTLV-1 infection.

Bronchoalveolar Lavage Fluid↗
PubMed1991

Disc edema in juvenile retinitis pigmentosa.

A 1-year-old girl had esotropia and bilateral mottled retina. At age 2 years, she had night blindness. At age 12 years, she had poor visual acuity, nystagmus, mottled retina, and unrecordable electroretinograms OU and a whitish swollen optic disc with retinal folds OD. We believe that this patient had an uncommon association of disc edema with juvenile retinitis pigmentosa.

Esotropia↗
PubMed1991

Quantitative study of the development of the optic nerve in rats reared in the dark during early postnatal life.

Male rats were placed in complete darkness from birth until 30 days of age, followed in some cases by a 35 days period of rehabilitation in control lighting conditions. Groups of control and experimental animals were killed at 30 and 65 days of age by perfusion with buffered 2.5% glutaraldehyde. The right optic nerve was dissected out from each animal and processed for embedding in Epon. Quantitative stereological procedures were used to estimate the total number of both myelinated and non-myelinated optic nerve fibres and their mean minimum diameters. There were no significant differences in the total number of optic nerve fibres between dark- and light-reared rats. However dark-reared rats had myelinated and non-myelinated fibres with significantly larger fibre diameters than those in age-matched light-reared rats. The proportion of optic nerve fibres which were myelinated increased with age in both groups of animals. However by 65 days of age the degree of myelination was slightly but significantly greater in the previously dark-reared rats than in the light-reared controls. These results indicate that rats reared in complete darkness for the first 30 days of postnatal life show morphological changes in the optic nerves. The possible significance of these changes is discussed.

Animals↗
PubMed1990

Subretinal hemorrhages with or without choroidal neovascularization in the maculas of patients with pathologic myopia.

We examined 20 patients (24 eyes) who had refractive errors of -8 diopters or more and subretinal hemorrhages at the initial visit. They were divided into two groups according to fluorescein angiographic findings: 15 eyes without choroidal neovascularization (CNV) and 9 eyes with CNV. Subretinal hemorrhage without CNV was frequent in patients aged 20-39 years (mean, 36.8 years). CNV was common in patients aged 60-79 years (mean, 61.0 years). No relationship was noted between refractive error and type of hemorrhage. In the eyes without CNV, the subretinal hemorrhages disappeared spontaneously after a few months. The visual acuity of these patients was variable at the initial visit (range, 0.01-0.8), and was unchanged or improved during the follow-up period. In the eyes with CNV, the visual acuity was less than 0.1 at the initial visit and was unchanged or worse during the follow-up period.

Adult↗
PubMed1990

Cutaneous eruption with or without ocular complications in patients with herpes zoster involving the trigeminal nerve.

We examined 62 patients with acute herpes zoster involving the trigeminal nerve; 13 had eruptions only and 49 (51 eyes) had eruptions with ocular complications. Bilateral involvement was found in two patients. The frequency of the disease appeared to increase with age, and the disease was least active in November. Patients with eruptions only demonstrated affected areas along the first, second, and/or third divisions of the trigeminal nerve. Ocular complications occurred in patients who had eruptions along the first and/or second divisions of the nerve, and they were usually noted in patients with eruptions on the tip and one side of the node. The ocular complications and associated systemic conditions varied.

Adolescent↗
PubMed1990

Test results in patients with Sjögren's syndrome defined by the Japanese criteria.

We examined 123 patients (mean age, 63.4 years) with Sjögren's syndrome at Shimane Medical University Hospital from 1980 to 1988. According to the Japanese criteria for Sjögren's syndrome, there were 106 definite and 17 probable cases. Female patients were predominant (74.8% to 25.5%). Most patients reported dry eye symptoms and had positive results on the Schirmer's, rose-bengal, and fluorescein tests. Although most patients described dry mouth symptoms, not all showed positive sialogram results, lymphocytic infiltrate on minor salivary glands, decreased salivary secretion, and salivary gland swelling. Connective tissue diseases were present in 28 patients. Most patients had positive antinuclear antibody reactions. Most of our patients who were diagnosed as having Sjögren's syndrome by the Japanese criteria could not be classified as such by the California, Copenhagen, or Greek criteria.

Adult↗