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Biomedical subjects

S Hayasaka

Publications and source records attributed to S Hayasaka.

At least 109 records · Page 6Linked to original sources
PubMed1995

[Evaluation of a respiratory care unit on a 45-bed hospital ward].

With a limited number of beds for patients undergoing medical and surgical treatment for respiratory diseases, we set aside 6 of 45 beds on one floor to be used as a respiratory care unit. During the past 5 years, 1820 patients (1225 medical and 595 surgical) were admitted to the respiratory care unit; they were treated for an average of 5.02 days. Of the patients being treated medically, 451 received mechanical ventilatory support. The majority of those patients had acute exacerbations of chronic respiratory failure due to emphysema or to sequelae of pulmonary tuberculosis. Acute respiratory distress associated with asthma or with pneumonia were also relatively common, as was the adult respiratory distress syndrome. A total of 119 patients on home oxygen therapy are being seen as out-patients, and the respiratory care unit was found to be quite useful whenever they needed intensive management. Only 148 (8.1%) of the patients admitted to the respiratory care unit died before discharge, and the ratio of cost to performance was good. The respiratory care unit was most effective in allowing for continuity of care from the onset of respiratory distress, and including exacerbations, surgical interventions, postoperative management, and out-patient care.

Female↗
PubMed1995

[Early phase II study of oral administration of etoposide for 21 consecutive days in patients with non-small-cell lung cancer].

An early phase II clinical study was done to investigate the activity and the safety of oral administration of etoposide for 21 consecutive days in patients with non-small-cell lung cancer. An interim analysis was done after registration of 24 cases. One case was a dropout because of an insufficient administration period (4 days). The other 23 cases were complete: they comprised 9 cases of adenocarcinoma, 13 cases of squamous cell carcinoma, and 1 case of large cell carcinoma. Prior therapy had not been given in two cases. The doses used were 50 mg/person/day in 12 cases and 75 mg/person/day in 11 cases. The response observed was one case of at 50 mg/person/day to stage IV squamous cell carcinoma, 17 cases were no change, 5 cases were progressing disease, and giving a response rate of 4.3% in complete cases. Considering those results, we decided that it would be difficult to achieve a 20% response rate by the end of this study, and therefore the study was terminated. The side effects of the regimen were tolerable. In conclusion, etoposide was not active against non-small-cell lung cancer at the dosage and schedule employed. Further investigation is required to obtain a more effective form of therapy.

Adenocarcinoma↗
PubMed1995

Nondetectable cone and rod electroretinographic responses in a patient with Cockayne syndrome.

A 10-year-old girl complained or poor vision in both eyes. The patient showed progeria, physical and mental retardation, sensorineural hearing loss, cutaneous photosensitivity, hyperopia, poor pupillary dilation, exotropia, salt-and-pepper fundi, nondetectable cone and rod electroretinographic (ERG) responses, cerebral atrophy on computed tomography, and demyelination of periventricular white matter on magnetic resonance imaging. We believe that nondetectable cone and rod ERG responses in Cockayne syndrome, as demonstrated in our patient, may be uncommon.

Brain↗
PubMed1994

HLA antigens in a Japanese family with Behçet's disease.

BACKGROUND: Familial Behçet's disease is rare. METHODS: HLA antigens in a Japanese family with Behçet's disease were examined. RESULTS: The affected patients had HLA B51, and unaffected family members also had the same antigen. CONCLUSION: It is likely that not only HLA B51 but also other factors may be involved in the pathogenesis of Behçet's disease in Japanese patients.

Adult↗
PubMed1994

Sebaceous gland carcinoma of the eyelid presenting as a conjunctival papilloma.

A 70-year-old man complained of the sensation of having a foreign body in his left eye in June 1992. A papillary tumor was found growing from the palpebral conjunctiva of the left upper eyelid. On June 30, the conjunctival tumor was excised: the histopathologic findings indicated a malignancy. On August 18, full-thickness excision of the upper eyelid, including the rest of the tumor, was performed. Histopathologic findings showed a well-differentiated sebaceous gland carcinoma. We believe that sebaceous gland carcinoma presenting as conjunctival papilloma, as found in our patient, may be uncommon.

Adenocarcinoma, Sebaceous↗
PubMed1994

Bilateral congenital grouped pigmentation of the retina in a patient with left superior rectus muscle palsy.

A 39-year-old man with left superior rectus muscle palsy had many sharply circumscribed, variable-sized pigmented spots in both fundi. His visual acuity, visual fields, and color vision appeared normal bilaterally. The electroretinographic responses were also normal. His family members were unaffected by pigmented spots in the retina. We believe that the bilateral congenital grouped pigmentation of the retina found in our patient may be rare.

Adult↗
PubMed1994

Visual prognosis in patients with Behçet's disease receiving colchicine, systemic corticosteroid or cyclosporin.

We reviewed retrospectively the charts of 36 patients (72 eyes) with Behçet's disease. The visual acuities in 21 patients receiving colchicine (group A) gradually decreased with time. The visual acuities in 9 patients receiving colchicine and systemic corticosteroid (group B) gradually decreased after the onset of the disease and were significantly worse than those in group A 10 and 15 years after onset. The visual acuities in 6 patients receiving colchicine and cyclosporin (group C) gradually decreased, and their visual acuity scores were similar to those in group A.

Adult↗
PubMed1994

Transconjunctival and transantral approaches are combined with antral wall bone graft to repair orbital floor blow-out fractures.

Orbital floor blow-out fractures in two patients were surgically repaired. The transconjunctival approach alone was unsuccessful in freeing the entrapped orbital contents, so the transantral approach with the use of antral wall bone graft was also used. The combined approaches produced good results. The transconjunctival approach supplemented with the transantral approach and bone graft may be a useful technique in the repair of orbital floor blow-out fractures.

Adolescent↗
PubMed1994

No pigment deposition in a patient with advanced retinitis punctata albescens.

A 51-year-old woman had had night blindness since childhood and a progressive visual field defect. She was the product of a consanguineous marriage. The patient also exhibited numerous whitish-yellow punctate spots with no pigment deposition in her fundi, nonrecordable electroretinographic responses after 30 min of dark adaptation, and constricted visual fields bilaterally. We believe that our patient may be a case of retinitis punctata albescens without pigment.

Consanguinity↗
PubMed1994

Body and brain development following exposure to 60Co gamma-irradiation during pregnancy in mice.

We studied the dose-response effects of gamma-irradiation on the weight gains of the body and the brain in ICR mice exposed to various doses of 60Co gamma-irradiation ranging from 0 to 1.5 Gy on day 13 of pregnancy (El3). We found that 0.5 Gy gamma-irradiation caused a significant reduction in brain weight but not in body weight among 6-week-old mice. Higher doses (1.0, 1.5 Gy) seriously inhibited body and brain development, resulting in significantly low weights at 6 weeks of age. A significantly lower brain weight among fetuses exposed to 1.5 Gy was found as early as 24 hours after exposure, while significant reductions in the body weight of these same fetuses appeared 3 days after exposure. The effects of radiation on brain and body development were similar for both males and females.

Animals↗
PubMed1994

Elevated anti-human T-cell lymphotropic virus type I antibody in serum of patients with retinal vasculitis and uveitis living in Izumo area.

Four patients with human T-lymphotropic virus type I associated myelopathy (HAM) were examined ophthalmologically, and serum titers to human T-lymphotropic virus type I (HTLV-I) in 11 patients with nonspecific retinal vasculitis or uveitis were determined. All of the patients lived in the Izumo area. All 4 patients with HAM (Cases 1 to 4) had vitreous opacities. Of the 11 patients with nonspecific retinal vasculitis or uveitis, 3 (Cases 5 to 7) had elevated titers to HTLV-I. We believe that HTLV-I infection may be involved in the causes of retinal vasculitis and uveitis in patients living not only in the endemic area but also outside the endemic area.

Adult↗
PubMed1994

[Clinical effects and safety of granisetron administration against CDDP chemotherapy in lung cancer. Lung Cancer Study Group].

Granisetron (3 mg/body) was administered immediately before single CDDP administration (80 mg/m2 or more) to 53 patients with lung cancer. This chemotherapy was performed a total of 73 times. Concerning Grade 2 or 3 nausea and vomiting, good conditions were observed on day 1 (day of treatment), most marked aggravation on day 2, and initiation of improvement on day 4. Vomiting was slight on day 1, most aggravated on day 2, but began to improve on day 3; good results were generally observed thereafter. Decreased appetite was slight on day 1, but was most aggravated on day 3 and 4; its recovery was delayed even until day 7. In the treatment for delayed emesis, comparison was made among the group treated with granisetron alone who did not require treatment for delayed emesis, the group with delayed emesis treated with granisetron, and the group with delayed emesis treated with drugs other than granisetron. Slightly better results were observed in terms of nausea, vomiting, and the frequency of vomiting in the group treated with granisetron alone on days 2 and 3. However, no significant difference was observed in decreased appetite among the 3 groups. Granisetron had no side effects and was safe. It inhibited vomiting, but measures to improve decreased appetite are needed.

Adult↗
PubMed1993

Plasma glucose levels, postoperative complications, and progression of retinopathy in diabetic patients undergoing intraocular lens implantation.

Of 220 patients (250 eyes) who underwent extracapsular cataract extraction with implantation of a posterior chamber intraocular lens, 36 (45 eyes) with non-insulin-dependent diabetes mellitus had no retinopathy, simple, or preproliferative retinopathy. They were divided into group A patients who underwent diet therapy or were treated with oral agents and group B patients who were given insulin therapy. The 184 patients (205 eyes) without diabetes mellitus served as control (group C). Transient elevation of intraocular pressure and cystoid macular edema were observed more frequently in diabetic patients (groups A and B). Progressive retinopathy occurred more frequently in group B than in group A patients, and it correlated with increased levels of plasma glucose. Unilateral cataract surgery was performed on 27 diabetic patients. Nine (33%) operated eyes showed progressive retinopathy, while one (4%) fellow eye worsened. It is possible that both increased levels of plasma glucose and surgical procedures may participate in the progression of retinopathy.

Adult↗
PubMed1993

Increased D-arabinitol/creatinine ratio in sera of patients with Behçet's disease during an active phase.

The ratios of D-arabinitol (a major metabolite of Candida species) to creatinine were examined in 46 sera of 40 patients with ocular inflammatory disease and in 50 age-matched normal controls (25 men and 25 women). The mean ratio in patients with endogenous Candida endophthalmitis was higher than in the normal controls. Seven samples taken from patients with Behçet's disease during an active phase showed higher values than in the controls. Fourteen patients with Behçet's disease in remission showed D-arabinitol/creatinine values within normal range. In four patients with sarcoidosis, in two patients with Vogt-Koyanagi-Harada disease, and in 16 patients with bilateral uveitis of an unknown cause, the ratios were within normal range. It is possible that D-arabinitol, or a metabolite of Candida species, may be related in part to the active phase of Behçet's disease.

Adult↗
PubMed1993

Psychiatric complications after ocular surgery.

Delirium was demonstrated after cataract surgery in a 64-year-old man (case 1). The patient struck his head against the floor; thereafter an extradural hematoma was found and extracted. Postoperative delirium was also noted in a 58-year-old woman (case 2) and in a 26-year-old woman (case 3) with rhegmatogenous retinal detachment. All 3 patients recovered from their psychiatric complications within 1 month.

Adult↗
PubMed1993

Corneoscleral ulceration and corneal perforation after pterygium excision and topical mitomycin C therapy.

A 78-year-old woman complained of ocular pain in the right eye. Thirty-three months before, the patient had a pterygium excised and mitomycin C, 0.04%, was instilled 3 times a day postoperatively for 10 days in the right eye. The same surgery was performed and the same drug was used for a course of 5 days in the left eye. Corneoscleral ulceration and corneal performation occurred in the right eye. The lesions were successfully treated with a lamellar patch graft with reserved corneosclera. We believe that it may not be safe to instill 0.04% mitomycin C 3 times a day postoperatively for 10 days.

Administration, Topical↗