[Administration of hydroxyzine as a preanesthetic].
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Adolescent↗
Biomedical subjects
S Hasebe
Publications and source records attributed to S Hasebe.
Studies on the intra-hepatic nerves in cirrhotic liver.
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Animals↗
Clinical studies of ocular motility disturbances: Part 2. Risk factors for ischemic ocular motor nerve palsy [corrected].
A case-control study of 46 Japanese patients who were diagnosed by exclusion as having ischemic ocular motor nerve palsy and who exhibited spontaneous recovery within 4 months was done to evaluate the risk factors involved. We also evaluated the association between the number of risk factors and the spontaneous recovery or recurrence periods. Ischemic ocular motor nerve palsy is closely related to diabetes mellitus and coronary artery disease. Patients tended to be obese; many had two or more risk factors. Aging, in combination with two or more risk factors, seems to increase the likelihood of developing this disease. Diabetes mellitus is a particularly significant risk factor for this type of palsy, especially in combination with hypertension.
Adult↗
Preoperative factors influencing effectiveness of surgery in adult strabismus.
To identify preoperative factors which influence the effectiveness of strabismus surgery in adults, we retrospectively reviewed the records of 179 patients > 15 years old (131 with exotropia, 48 with esotropia) who had had combined recession and resection surgery for correction of horizontal strabismus. Eighteen preoperative variables were evaluated; those with significant influence on the surgical outcome, measured by the degree of change in deviation per millimeter of surgery, were identified by stepwise regression analysis. In patients with exotropia, preoperative distance deviation and average spherical equivalent were significant predictors of outcome at both 1 month (multiple R, 0.37) and 6 months (0.63) after surgery. In esotropic patients, significant variables at 1 month (multiple R, 0.57) and 6 months (0.77) were preoperative distance deviation and dissociated vertical deviation (DVD). Preoperative distance deviation is the common significant influence on surgical effectiveness for horizontal strabismus in adults, for both exotropia and esotropia. Additional significant predictors are average spherical equivalents in exotropic patients, and DVD in esotropic patients.
Adolescent↗
Predictors of postoperative binocularity in adult strabismus.
We evaluated postoperative binocularity in a retrospective study of 111 adult strabismus patients in order to identify the factors which influence the success of surgery for horizontal concomitant strabismus in adults. Selection criteria included minimum age of 15 years at time of surgery, and preoperative fusion impairment with both the Bagolini lens test and synoptophore. Logistic regression analysis was used to correlate patient factors and postoperative binocularity. We found that 52 (65%) of 80 patients with exotropia and 23 (74.2%) of 31 patients with esotropia achieved post operative fusion. Significant predictive factors in exotropia were absence of previous surgery; visual acuity of the deviating eye > 0.5; an increase in the spherical equivalent of the deviating eye, and normal retinal correspondence. Significant predictive factors in esotropia were fusion during prism adaptation, absence of infantile esotropia, and an increase in vertical deviation. The majority of adults with exotropia or esotropia can achieve binocularity after surgery for horizontal concomitant strabismus.
Adolescent↗
Characteristics and variability of vertical phoria adaptation in normal adults.
We evaluated the characteristics of phoria adaptation for vertically induced retinal disparity. An adaptive change in the fusion-free ocular alignment, phoria adaptation, was measured with a computer-aided mirror haploscope at 10, 30, and 60 minutes after the start of wearing of a 3-prism-diopter base up prism by 35 normal subjects ranging in age from 21 to 67 years (mean: 37 years). The relationships between phoria adaptation and the subjects' age, the vertical fusional amplitude, the amount of heterophoria, and the starting time of the examination were evaluated. All subjects showed phoria adaptation, with the mean (+/- SD) degree of 0.78 +/- 0.28 degree, 0.96 +/- 0.26 degree and 1.02 +/- 0.30 degrees at 10, 30, and 60 minutes, respectively, after wearing the prism. The repeatability (95% confidence interval) for the measurements was less than +/- 0.24 degree. There was a significant correlation between the vertical fusional amplitude and the gain of phoria adaptation (at 10 and 60 minutes, P < 0.05). The gain of phoria adaptation measured at 60 minutes showed a significant decrease with age (P < 0.01). The results indicate that the time course of phoria adaptation in the vertical direction is similar to that in the horizontal direction and its gain differs considerably among subjects.
Adaptation, Ocular↗
Mastoid condition and clinical course of cholesteatoma.
This study was carried out to establish which type of cholesteatoma is controllable by conservative treatment from the viewpoint of mastoid ventilation. We examined the area of the air cell system and airspace (aeration) in the mastoid cavity by computed tomography and eustachian tube (ET) function by inflation-deflation test in 20 ears (20 patients) with severe attic retraction for over 12 months (retraction pocket group), 16 ears (16 patients) with cholesteatoma which could be controlled only by conservative treatment for over 12 months (nonsurgical group) and 43 ears (43 patients) which required surgery within a year in spite of similar conservative treatment (surgical group). The size of the mastoid air cell system in the retraction pocket group, nonsurgical group and surgical group was 2.9 +/- 1.3, 1.9 +/- 0.7 and 1.5 +/- 0.9 cm(2) on average, respectively, with no significant difference between both cholesteatoma groups (nonsurgical and surgical group). While aeration was observed in the mastoid in 17 of 20 ears (85.%) in the retraction pocket group and in 12 of 16 ears (75.0%) in the nonsurgical group, aeration was present only in 9 of 43 ears (26.5%) in the surgical group, being significantly less in the surgical group than in the nonsurgical group and the retraction pocket group. In all ears in the retraction pocket and nonsurgical groups, and 19 of 30 ears in the surgical group, ET function was poor, there being no significant difference among the three groups. The present clinical observations suggest that progressiveness of cholesteatoma could be related to the ventilatory conditions in the mastoid rather than ET function, and that conservative treatment may be effective when ears with cholesteatoma have aeration in the mastoid.
Adolescent↗
Advancement of medial rectus muscle to the original insertion for consecutive exotropia.
Twenty-four patients who underwent surgery to correct consecutive exotropia that developed iatrogenically after surgical overcorrection were studied retrospectively. All patients underwent single or bilateral advancement of the medial rectus muscle to the original muscle insertion. The mean preoperative exodeviation was 26.7 prism diopters at distance and 35.2 delta at near. Postoperatively, in cases receiving advancement of a single medial rectus, the mean amount of correction was 23.2 delta at distance and 29.6 delta at near. In cases receiving bilateral medial rectus advancement, the mean amount of postoperative correction was 26.3 delta at distance and 39.8 delta at near. Adduction deficiency was normalized in five patients (71%), while convergence insufficiency was improved in only nine patients (45%) after surgery. Twelve (50%) patients had binocular single vision at distance on a normal or abnormal basis as determined by the Bagolini lens test.
Adolescent↗
Predicting survival and post-operative complications with Tc-GSA liver scintigraphy in hepatocellular carcinoma.
BACKGROUND/AIMS: Technetium-99m galactosyl human serum albumin is a novel liver scintigraphic agent. The aim of the present study was to examine whether liver scintigraphy with this agent could predict changes in hepatic function affecting survival in patients with inoperable hepatocellular carcinoma and liver cirrhosis. We also investigated whether the risk of major complications after hepatectomy for hepatocellular carcinoma could be assessed. METHODOLOGY: Liver scintigraphy was performed in 42 patients with inoperable hepatocellular carcinoma and cirrhosis and 40 patients undergoing hepatectomy. The ratio of liver to heart plus liver radioactivity 15 min after injection (LHL15) was calculated. RESULTS: The 1-year survival rates were higher in patients with higher LHL15: 100%, LHL15 > or = 0.91; 77.8%, 0.81 < or = LHL15 < or = 0.90; and 28.6%, LHL15 < or = 0.80. On multifactorial analysis, LHL15 significantly predicted the 1-year mortality rate in the 42 patients (p<0.001). Pre-operative LHL15 was significantly lower in 9 patients with major post-operative complications (0.88+/-0.02) than in 31 patients with uneventful courses or minor post-operative complications (0.93+/-0.01, p<0.001). CONCLUSIONS: Our results suggest that technetium-99m galactosyl human serum albumin liver scintigraphy is effective for predicting short-term survival in patients with inoperable HCC and cirrhosis and for assessing the risk of major complications after hepatectomy.
Aged↗