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Biomedical subjects

S Harris

Publications and source records attributed to S Harris.

At least 361 records · Page 20Linked to original sources
PubMed1977

Evaluation of the prison inmate as a subject in drug assessment.

The reasons for exclusion of prisoners from research studies on drugs were based mostly on a relatively limited group of laboratory parameters which could have been detected using a simple battery of screening tests. The answers to a medical history form added little to the evaluation of either the prisoner or student groups, were probably very unreliable, and could be just as well confined to a few selected questions regarding drug history as a matter of record. Students gave appropriate responses to a mood scale measurement test while prisoners characteristically did not comply. Because of a combination of various institutional and sociological factors, prisoners probably represent a special subgroup of research volunteers whose health status may not be representative of the total "healthy" population. They are unlikely to give accurate or reliable responses in testing situations which rely upon reporting of the subjective effects of drugs with regard to tolerance or pharmacologic effect. Studies of investigational drugs where the likelihood of potentiaal risk is significant should be avoided in such populations unless compliance has been assessed adequately.

Adolescent↗
PubMed1976

Some cognitive, behavioral and personality correlates of maturity of moral judgment.

This study was designed to test the hypothesis that maturity of moral judgment is related to moral behavior and to certain personality characteristics. The Ss, 33 fifth grade boys (approximately 10 1/2-years of age), were given the Kohlberg test of moral judgment, and scores on this test were related to a measure of general intelligence, moral conduct as judged by peers (sociometric nominations), honesty in a structured test, and certain personality variables. Maturity of moral judgment was found to be significantly correlated with general cognitive ability (intelligence test performance) and, even with intelligence partialed out, with resistance to temptation, reputation for being concerned with the welfare of others, self-confidence, and security in social relationships with peers.

Child↗
PubMed1976

Community-based residential care for the minimally impaired elderly: a survey analysis.

Foster home care for the elderly, as an alternative to living independently, living with relatives or living in an institution, has been a neglected area of investigation, although such care is a nationwide phenomenon. This survey of all licensed Family Care Home operators in the Louisville, Kentucky area provides baseline data regarding the characteristics of providers of adult foster care and the recipients. Data were obtained from 183 persons caring for minimally impaired adults in their own homes and on 422 residents in these foster home settings. Of the residents, 69.5 percent were aged 65 or over. Care providers are described on the basis of age, race, sex, educational level, family size and composition, previous employment, reasons for entering the business, and problems encountered. Residents are described on the basis of age, race, sex, physical condition, care required, and outside contacts. Foster home care for the aged can furnish many advantages if the resident is properly placed and support services are provided. This form of care deserves much greater emphasis in future research of the provision of services for the elderly.

Activities of Daily Living↗
PubMed1976

Treatable aspects of the dementia syndrome.

With attentive medical management, the elderly demented patient can live in greater comfort, dignity and independence. Errors in supervision can result in a drug intoxication, misdiagnoses, and personal neglect. Many of the elderly have a chronic dementing illness, and disability often is accelerated by complications. However, some of these complications are treatable. Case histories are presented to illustrate pitfalls in the care of such patients.

Adjustment Disorders↗
PubMed1976

Enhancement of tumor growth following immunization with Bacillus Calmette-Guérin cell walls.

The effect of preimmunization with Bacillus Calmette-Guerin cell walls (BCGcw) on tumor growth was studied with the use of transplantable Morris Hepatoma 3924a in inbred ACl rats. There was an increase in tumor incidence, an increase in the i.m. tumor growth rate, and an increase in the average i.m. tumor mass in animals that were preimmunized with BCGcw. The BCGcw-induced enhancement in tumor growth was dependent upon the amount of tumor present at the time of BCGcw immunization. No enhancement occurred in animals immunized with BCGcw 12 days after the inoculation of tumor cells.

Animals↗
PubMed1975

Detection of antigens specific for B-lymphoid cultured cell lines with human alloantisera.

Human sera were tested for cytotoxicity to pairs of long-term tissue-cultured cell lines. Each pair had been derived from the same individual and one of the pairs possessed the characteristics of either "T" or "B" cells. The alloantisera used were HL-A-typing reagents or sera obtained from Amish multiparas. Selected cytotoxicity was found against the B-cell lines by direct testing. Cytotoxicity was abolished by absorption with B-cell line but not by absorption with the T-cell lines. The results suggest that a group of allotypic antigens may be expressed exculsively on human B cells.

B-Lymphocytes↗
PubMed1975

A preparation of Fc fragment of normal mouse IgG1 for production of rabbit anti mouse IgG1 serum.

Ascitic fluid globulins obtained by peritoneal irritation from normal CBA mice were digested with papain, and the digests were examined by gradient chromatography on CM cellulose. The classical three peaks of OD280 found by Porter with papain digests of rabbit IgG were obtained. Fraction II contained material which reacted in immunodiffusion against mouse anti-IgG. The ascending part of this peak reacted against anti-IgG1 and not against anti-TgG2 reacting material appearing at detectable levels in the descending part of this peak. A pool from the ascending part of this peak, containing Fc of IgG1 and not visibly contaminated with Fc of IgG2, was injected into rabbits. The resulting antisera were free enough of anti-IgG2 to be effective in removing IgG1 from alloantibody-containing globulins without appreciable loss of antibodies of IgG2 class, thus allowing the complement-dependent IgG2-class antibodies full expression of their titer, without competition by Ig1 class antibodies. Chromatography of native mouse globulin did not produce a similar degree of separation of Ig1 from IgG2.

Animals↗