A computerized system for recording results of ear surgery is presented. Specially designed forms are filled in at the time of operation as well as 2 months, 6 months and annually for 1-5 years after operation. The data are processed in a Univac 1100-80 by specific programmes written in FORTRAN. A Follow-up programme gives up-to-date information on hearing and healing after different types of operations. An Annual Production Control programme gives more detailed information about various correlations, such as results in draining ears, frequency of residual cholesteatoma etc. Four years experience with the system and obtainable data is discussed.

Adolescent↗

PubMed1981

The relationship between hyperglycaemia and renal immune complex deposition in mice with inherited diabetes.

Kidney lesions were studied by light microscopy and immunofluorescence in diabetic (db/db) and obese (ob/ob) mutant mice. The db/db mutation was studied both on the C57Bl/KsJ genetic background (where it produces severe hyperglycaemia) and on the C57Bl/6J background (where hyperglycaemia is only mild). In all cases, more IgG, IgM and C3 were deposited in the renal glomeruli of mutant mice than in the glomeruli of normal (+/?) mice of equivalent age. First signs of immunoglobulin deposition occurred at a slightly younger age than first signs of C3 deposition or histological change (mainly mesangial thickening). Insulin deposits were occasionally seen in the glomeruli of older mutant mice and immunoglobulin eluted from diabetic mouse kidneys had anti-insulin activity. Increased anti-DNA activity was present in the serum of older mutants. In those mutants with severe hyperglycaemia, the macula densa and distal convoluted tubules also contained immunoglobulin deposits, probably derived from the glomerular mesangium. Urine from diabetic mice contained high molecular weight material reacting with antisera to Fab or kappa but not the Fc portion of immunoglobulin. We conclude that diabetic mice have immune complexes in the kidney containing antibodies against insulin and possibly other antigens. We find no evidence that hyperglycaemia itself is the direct cause of glomerular immune complex deposition, although there may be a link between hyperglycaemia and tubular dysfunction.

Animals↗

PubMed1980

Tonsillectomy and childhood Hodgkin's disease.

The relation between previous tonsillectomy and Hodgkin's disease was examined in a case-control study involving 81 histologically confirmed childhood cases and two sibling control groups. When cases were compared with age-matched sibling controls a significant association (p < 0.02), with a risk of 2.7, was observed for children who had undergone tonsillectomy. A significant association (p < 0.01), with a relative risk of 2.5, was also shown when all siblings were used for comparison. History of hospital admissions, age at tonsillectomy, Rye histological subtype, birth order, and sibship size did not appear to modify the effect of this operative procedure on the risk of Hodgkin's disease.

Adult↗

PubMed1980

Comparison of sperm velocity in fertile and infertile groups as measured by time-lapse photography.

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Female↗

PubMed1980

The effect of alterations in the pituitary-thyroid axis on hypothalamic content and in vitro release of somatostatin-like immunoreactivity.

The role of somatostatin (SRIF) in the regulation of thyroid homeostasis was studied by measuring hypothalamic SRIF-like immunoreactivity (SRIF-LI) content and in vitro release in hypothyroid (T3-treated and untreated), euthyroid, and T3-treated normal rats. Hypothalamic SRIF-LI content was decreased in hypothyroid rats and was restored to euthyroid levels by T3 treatment. SRIF-LI release from hypothalami of hypothyroid rats was decreased compared to that in euthyroid controls under basal and stimulated (60 mM K+ or 10(-6) M dopamine) in vitro conditions. The release of SRIF-LI from hypothalami of hypothyroid rats treated with T3 was restored to euthyroid levels. The release of SRIF-LI from normal rat hypothalami was unaffected by TRH or TSH but was stimulated by T3. These results suggest that T3 exerts its negative feedback effect on pituitary TSH release via stimulation of hypothalamic SRIF release as well as by a direct pituitary effect, and that the elevated TSH levels seen in primary hypothyroidism may result in part from a decrease in the tonic inhibitory effect of hypothalamic SRIF. Pancreatic, but not antral or colonic, SRIF-LI was increased in hypothyroid rats, and the levels were reduced by T3 treatment. The changes cannot be explained by alterations in food intake and may represent primary effects of the hypothyroid state.

Animals↗

PubMed1980