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Biomedical subjects

S Handa

Publications and source records attributed to S Handa.

At least 379 records · Page 21Linked to original sources
PubMed1982

[Echocardiographic findings of a patient with cardiac amyloidosis and left ventricular outflow obstruction].

This report described 56-year-old male with cardiac amyloidosis, whose echocardiographic and hemodynamic findings suggested hypertrophic obstructive cardiomyopathy. M-mode echocardiography demonstrated asymmetric septal hypertrophy (2.1 cm/1.6 cm), systolic anterior motion of the mitral valve, and pericardial effusion. Two-dimensional echocardiography revealed marked hypertrophy of the septum and papillary muscles with characteristic fine grannular sparkling appearance of the myocardium. Bilateral heart catheterization showed normal hemodynamics except a pressure gradient of 35 mmHg within the left ventricular outflow tract. Moreover, no hemodynamic evidence of restrictive cardiomyopathy was observed. Myocardial biopsy was performed at the time of pericardiectomy, and diffuse amyloid deposits were identified between myocardial fibers. It is of particular interest that cardiac amyloidosis presented the form of ventricular hypertrophy associated with left ventricular outflow obstruction, probably due to uneven deposition of amyloid.

Amyloidosis↗
PubMed1982

[Evaluation of mitral valve, subvalvular structures and valvular flexibility in mitral stenosis by two-dimensional echocardiography].

UNLABELLED: In order to identify the determinants for surgical procedures in mitral stenosis, we evaluated two-dimensional echocardiographic findings of the mitral valve and subvalvular structures in 35 patients undergoing open mitral commissurotomy (OMC) or valve replacement (MVR). As indices of a degree of subvalvular shortening and valvular flexibility, the distance between the mitral ring and the tip of the anterior mitral leaflet was measured by the LV long-axis view by in both midsystole (S) and early diastole (D). As a possible major determinant for MVR, a degree of valvular calcification (C) was semi-quantatively scored according to the extent of abnormally strong echo density. In nine of 11 patients undergoing MVR, a main reason for selecting MVR was a marked thickening or shortening of subvalvular structures. In patients in whom OMC was feasible, the degree of improvement of the mitral valve area (delta MVA) was assessed by the pre- and post-operative mitral valve areas (MVA) measured on the LV short-axis view, which were averaged 0.15 and 1.38 cm2, respectively. RESULTS: The index C was significantly higher in cases with MVR than those with OMC (9.2 +/- 2.6 vs 4.7 +/- 2.3 points, p less than 0.001), although there was a significant overlap between these two groups and index C did not correlate with delta MVA in the OMC patients. Similarly, the value S was significantly smaller in patients undergoing MVR than those undergoing OMC (1.2 +/- 0.4 vs 0.7 +/- 0.2 cm, p less than 0.001), though S did not correlate with delta MVA. On the other hand, the index of valve flexibility D--S was smaller in patients undergoing MVR (0.5 +/- 0.3 vs 0.8 +/- 0.3 cm, p less than 0.05) and correlated well with delta MVA (delta MVA = 0.699 x (D--S)+0.007, R = 0.678, p less than 0.02) in patients undergoing OMC. Furthermore, in all patients undergoing OMC with D--S greater than or equal to 0.8 cm, delta MVA was above 0.5 cm2, contrasting with delta MVA of 0.5 cm2 or less in 6 of 7 patients with D--S less than 0.7 cm. Using these indices, surgical procedures were successfully predicted in another 7 prospectively studied patients and predicted delta MVA in 4 patients was quite comparable with actual delta MVA. It was concluded that measurements of S and D by two-dimensional echocardiography are useful, 1) to predict patients requiring MVR and 2) to predict patients with inadequate delta MVA in whom OMC is surgically feasible.

Adult↗
PubMed1982

[Two dimensional echocardiographic diagnosis of mitral valve prolapse syndrome in presumably healthy young students].

We studied the prevalence of mitral valve prolapse (MVP) in presumably healthy young students using two-dimensional echocardiography and compared their clinical pictures with those of hospital patients with MVP. In 265 students undergoing routine physical examination (228 males and 37 females, aged from 18 to 25 years), 29 (11%) were diagnosed as having MVP. There was no sex difference (11% for males and 8% for females). Anterior leaflet prolapse was seen in 26 cases, and anterior and posterior leaflets prolapse was in 3 cases. Twenty-four of the 29 MVP students revealed neither midsystolic click, late systolic murmur nor holosystolic murmur on phonocardiograms (PCG). These 24 students had no cardiac symptoms and the incidence of electrocardiographic (ECG) abnormalities, such as arrhythmias and ST-T changes, was similar to that of students without MVP (4/24 vs 50/236). In contrast, of 54 patients (32 males and 22 females, aged from 15 to 25 years) who were diagnosed as having MVP in the hospital, 28 patients (52%) had no PCG abnormalities. The anterior leaflet was predominantly involved in 42 patients and both anterior and posterior leaflets in 12 patients. These 28 patients visited the hospital because of cardiac symptoms; dyspnea on exertion (3 patients), palpitation (2 patients) or atypical chest pain (7 patients), or abnormal physical examination (11 patients). ECG abnormalities were noticed in 15 of 28 patients (54%). The prevalence of cardiac symptoms and ECG abnormalities were similar to those in 26 patients with PCG evidence of MVP. It was concluded that the prevalence of MVP in young healthy students is 11% and the anterior leaflet is predominantly involved. Most cases were asymptomatic and had no PCG or ECG abnormalities. In contrast, age-matched MVP patients, diagnosed in the hospital with the same two-dimensional echocardiographic criteria, demonstrated similar predominancy of the anterior leaflet prolapse, but had more cardiac symptoms and ECG abnormalities, irrespective of the presence or absence of PCG findings.

Adolescent↗
PubMed1981

Two dimensional echocardiographic analysis of wall motion abnormalities during handgrip exercise in patients with coronary artery disease.

Studies were made of the feasibility and value of two dimensional echocardiography in detecting left ventricular asynergy during handgrip exercise in 45 patients with suspected coronary artery disease. Resting echocardiography revealed normal wall motion in 32 patients, and in 17 of these handgrip exercise induced abnormal wall motion. All 17 patients had significant stenoses in the coronary arteries. However, only 65 percent of patients with coronary artery disease whose resting two dimensional echocardiogram revealed normal wall motion showed abnormal wall motion during handgrip exercise. The left ventricular wall visualized in the short axis plane was divided into 5 segments, and a total of 225 segments were analyzed. Of 49 segments with exercise-induced asynergy, 46 (94 percent) reflected significant stenosis in the perfusing coronary artery. In particular, 16 (89 percent) of 18 segments with exercise-induced akinesia reflected stenosis of greater than 90 percent. Resting or exercise two dimensional echocardiography (or both) was able to diagnose multivessel disease with a predictability of 92 percent. It is concluded that two dimensional echocardiography combined with handgrip exercise has high specificity in detecting coronary artery disease and would be useful for predicting severely stenotic or multivessel coronary arterial lesions.

Adult↗
PubMed1981

A case of coexisting tachycardia- and bradycardia-dependent bilateral bundle branch block.

Electrocardiograms and His bundle electrograms were presented from a patient with a rare combination of intermittent bilateral bundle branch block. Critical analyses of R-R intervals and evolution of bundle branch block patterns revealed both tachycardia dependent right bundle branch block and bradycardia dependent left bundle branch block. Evaluation of HV intervals on His bundle electrograms suggested an additional possibility of bradycardia dependent conduction delay in the right bundle branch system.

Aged↗
PubMed1981

[Two-dimensional echocardiographic approach to the localization of myocardial infarction: echocardiographic, electrocardiographic, and coronary arteriographic correlations (author's transl)].

Location of infarct lesions (IL) demonstrated by two-dimensional echocardiography (2DE) was correlated with electrocardiographic patterns of myocardial infarction and with the sites of obstructive lesions in the individual coronary arteries. The left ventricular wall was displayed by phased-array 2DE in 47 patients with healed myocardial infarction, 29 of whom underwent coronary arteriography. Segmental analysis of IL was performed on 14 segments, 10 of which were obtained by the parasternal short-axis recordings at the mitral (basal) and papillary muscle (mid) levels (each level containing the anterior septum, anterior wall, lateral wall, posterior wall, and posterior septum). The remaining 4 segments (septum, anterior wall, lateral wall, posterior wall) were obtained by the apical 2-chamber and 4-chamber recordings. IL were defined as akinesis, thinning, increased echo density, or absent systolic thickening of the left ventricular wall. All 22 patients with anterior infarction (Q in V1-V4) had IL in the mid anterior septum which was specific for the lesion of the left anterior descending artery (LAD). The presence or absence of the r wave in V1 could not predict the involvement of this segment. IL in the apical anterior wall and septum were observed in 21 of 22 patients. The presence of Q waves in V5, V6 suggested the additional involvement of the apical posterior wall. Additional Q waves in I, aVL indicated the extension of IL from the mild anterior septum to the basal anterior septum, anterior wall, and mid anterior wall. The basal and mid lateral walls appeared normal in most patients. This pattern of IL distribution was observed in 5 of 6 patients with a stenosis on the proximal LAD. All 14 patients with inferior infarction (Q in II, III, aVF) had IL in the mid posterior wall and posterior septum. In contrast, 5 patients with infero-posterior infarction (Q in II, III, aVF + R in V1) and 6 patients with posterior infarction (R in V1) had IL in the mid lateral as well as the mid posterior wall without an involvement of the posterior septum. Coronary arteriography revealed that all of the 10 patients with inferior infarction had a stenosis in the right coronary artery, whereas 6 patients with infero-posterior or posterior infarction invariably had a stenosis in the left circumflex coronary artery. It was concluded that 2DE provides a reliable method for detecting IL and anatomic location of myocardial infarction reflecting a specific coronary artery disease.

Adult↗
PubMed1980

Further studies on gangliosides of erythrocytes from horses and cattle.

The ganglioside patterns of erythrocytes from individual horses and cattle were examined. Variations in the ganglioside patterns were found in both horses and cattle. In the erythrocytes of most horses examined, NeuGc-Gal-Glc-ceramide (NeuGc-GM3) of 25 horses examined had only NeuGc-GM3 with no 4-O-Ac-NeuGc-GM3. The erythrocytes of various breeds of cattle had a characteristic ganglioside pattern, but they could be divided into 4 types on the basis of the composition of their gangliosides.

Animals↗
PubMed1979

Occurrence of hematoside with two moles of N-acetyl-neuraminic acid in a certain breed of Persian cat.

The glycolipids of erythrocytes from individual cats were examined. The main glycolipid of cat erythrocytes was generally NeuGc-NeuGc-Gal-Glc-ceramide (NeuGc-GD3), but among 41 cats of 5 breeds and 2 mongrels examined, 2 Persian cats were found to have NeuAc-NeuAc-Gal-Glc-ceramide (NeuAc-GD3). This is the first report of the occurrence of NeuAc-GD3 in cat erythrocyte membranes.

Animals↗