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Biomedical subjects

S Hancke

Publications and source records attributed to S Hancke.

At least 55 records · Page 3Linked to original sources
PubMed1981

Nonsurgical internal biliary drainage by endoprosthesis.

Insertion of an endoprostheses for internal biliary drainage was attempted upon 150 patients with obstructive jaundice. It was successful in 123 patients, and 99 patients had permanent drainage with the endoprosthesis. The plasma bilirubin level became normal in 64 of the patients. The effect upon jaundice was equal to that in 43 patients who underwent operation with palliative surgical bypass. The median survival time was not different from that for the patients with surgical anastomoses. Twenty-eight patients died in the first month after insertion, mostly of advanced malignant disease. Fifteen of the patients in the group with surgical anastomoses died within the first month. The insertion of an endoprosthesis for bile duct obstruction is relatively easy and seems to have little risk. Most complications are caused by the transhepatic cholangiography procedure. The method may be used for temporary drainage before operation, in transient benign obstructions or as permanent drainage in unresectable lesions. In patients with dislodgement or insufficient function, additional endoprosthesis may be inserted. Thus, sufficient palliation of jaundice is achieved with a low frequency of cholangitis. Internal biliary drainage by insertion of an endoprosthesis is a valuable alternative to surgical bypass in patients with unresectable lesions.

Adult↗
PubMed1979

The effect of weight-lifting exercise related to muscle fiber composition and muscle cross-sectional area in humans.

Isometric and dynamic strength and endurance of knee extensors were tested in 18 young males. The relative composition of slow (ST) and fast twitch (FT) fibers in the vastus lateralis muscle was registered from needle biopsies. Thigh muscle volume was evaluated from ultrasonic measurements. Six subjects served as controls, six trained with 50%, and six with 80% dynamic strength three times per week for 7 weeks with 20 and 12 repetitions per session, respectively. The training load was adjusted to the increases in strength observed during training. Dynamic strength increased by 42.3% in the 80% group (p less than 0.01). In the control group and 50% group no significant increases were observed. Dynamic endurance: Controls showed no change. There was an over-all increase in the 50% group, while the 80% group only increased dynamic endurance for heavier loads. Isometric strength and endurance and fiber composition did not change in any group. In the 50% group the area of FT-realtive to ST-fibers increased 12.4% (p greater than 0.05). Dynamic strength relative to muscle cross section increased by 30% in the 80% group (p less than 0.01) positively correlated to relative content of FT fibers. The present results confirm the specificity of training and indicate that a high content of FT fibers is a prerequisite for a successful strength training.

Cell Count↗
PubMed1979

Localization of hormone-producing gastrointestinal tumours by ultrasonic scanning.

The value of ultrasonic scanning in the localization of hormone producing gastrointestinal tumours was assessed in 16 patients. Fifteen patients had Zollinger-Ellison syndrome and one patient had a VIP tumour. In four patients with Zollinger-Ellison syndrome ultrasonic scanning demonstrated a solid mass lesion of the head of the pancreas of 2.2.4 and 8 cm respectively. One of these diagnoses was verified by autopsy, one was also found by subsequent CT-scanning and angiography. In one patient ultrasonic scanning demonstrated a 3 cm tumour of the tail of the pancreas. At ultrasonically guided percutaneous fine needle biopsy tumour cells were aspirated. Biochemistry confirmed a VIP tumour. In 11 patients ultrasonic scanning was normal. By laparotomy in nine of these tumours of 1--3 cm were found in three patients 5.9 and 15 months after scanning and in two patients multiple 0.5 cm tumours within the duodenal wall were demonstrated one half and 9 months after ultrasound. In four patients tumours were not demonstrated by surgery. Two of the 11 patients were not operated upon, and the tumours have not been localized. The advantages of the complete atraumatic, rapid and relatively cheap ultrasound technique and the ability of an ultrasonically guided biopsy for the demonstration of malignancy justify ultrasonic scanning to be an initial method of investigation in the localization of hormone producing gastrointestinal tumours.

Evaluation Studies as Topic↗
PubMed1978

Determination of renal volume by ultrasound scanning.

In patients with renal hypertension, determination of renal volume may be valuable for evaluating possible compensatory hypertrophy for correlating renal size to renal function, and for evaluating the transplanted kidney in relation to rejection and its response to therapy. We performed parallel transverse ultrasonic scans through each kidney and computed volume based on the cross-sectional areas outlined on the scans. In 16 autopsy studies a highly significant correlation between calculated and true values were obtained, rs = 0.847, p less than 0.001. The 5th and 95th percentiles of the median divergence were -21 and 27 ml respectively. In 30 healthy subjects, double determinations showed 5th and 95th percentiles of the median interobserver variation of -7 and 3 ml respectively. There was no demonstrable difference between volumes of right and left kidneys, and no difference in relation to sex. Total renal volume was most accurate when correlated with the body weight, rs = 0.698, p less than 0.001. Normal values of total renal volume per kilogram of body weight were 4.3 to 8.0 ml/kg. In normal subjects, the smallest kidney's volume should not be less than 37% of the total renal volume.

Adult↗
PubMed1977

The diagnosis of pancreatic cyst by endoscopic retrograde pancreatography and ultrasonic scanning.

Fourteen patients with verified pancreatic cysts were examined by both preoperative endoscopic retrograde pancreatography (ERP) and ultrasonic scanning. ERP showed filling of a cyst in 4 patients and raised suspicion of a cyst in 8. In two patients it was not possible to visualize the pancreatic duct. Ultrasonic scanning showed a cyst in 12 patients. There were two false negative ultrasonic diagnoses. These two were correctly diagnosed by ERP. Ultrasonically guided percutaneous puncture was carried out on 19 occasions in 8 patients. Cysts down to 2 cm in diameter were punctured without difficulty. There were no clinically significant complications due to the punctures. One patient was followed for 20 months without ultrasonically demonstrable recurrence of a large cyst aspirated, showing that definite therapy is possible by this method. Puncture can be used to verify the diagnosis and as treatment in patients where surgery is contraindicated.

Diagnosis, Differential↗
PubMed1976

Comparative study of ultrasound, 131I-19-iodocholesterol scintigraphy, and aortography in localising adrenal lesions.

Twenty-seven consecutive patients with endocrinological disease necessitating adrenal surgery underwent blind preoperative investigation with ultrasound, renal aortography, and adrenocortical scintigraphy for an adrenal lesion. Nine patients had pituitary-dependent Cushing's syndrome, five had pituitary-independent Cushing's syndrome, four had an adrenocortical androgenic excess, and nine had a preoperative diagnosis of phaeochromocytoma. The predictive value of preoperative ultrasound was 100% for a positive finding and 79% for a negative result. Preoperative aortography had a predictive value of 83% for a positive finding and 64% for a negative result; and the predictive value of adrenocortical scintigraphy was 100% for a positive finding and 85% for a negative finding. In localising biochemically suspected adrenal lesions ultrasound should be the first choice, since it is rapid, noninvasive, cheap, and reasonably accurate. Adrenocortical scintigraphy has a similar diagnostic value, especially in Cushing's syndrome, but it is time consuming. Nevertheless, it may be preferable for diagnosing small glucocorticoid-secreting adenomas. Aortography should be reserved for cases with inconclusive diagnoses and suspected extra-adrenal phaeochromocytomas.

Adolescent↗
PubMed1976

Ultrasonic scanning of the pancreas.

The use of ultrasonic scanning in diagnosis of pancreatic disease is reviewed. A procedure for the examination of the pancreas with a compound scanning technique and the ultrasonic appearance of the normal and diseased pancreas is described. Diffuse or localized enlargement can be demonstrated and the latter be differentiated as to whether it is solid or cystic lesion. Percutaneous fine needle aspiration biopsy of solid lesions and percutaneous puncture of cysts can be performed with great accuracy under the guidance of ultrasound. Differential diagnosis and liminations in pancreatic scanning are discussed.

Acute Disease↗
PubMed1976

Ultrasonically-guided percutaneous nephrostomy. Report of 24 cases.

Ultrasonically-guided percutaneous nephrostomy using the Seldinger technique was attempted on 24 kidneys in 19 patients with obstructive hydronephrosis. Seventeen of the procedures were successful, 4 failed, and in 3 the catheter slipped out of the renal pelvis 1-48 hours after insertion. The procedure is simple and independent of renal function. Postrenal uremia can be relieved, infected hydronephrosis drained prior to elective surgery, and urinary parameters assessed. Injection of contrast material can define pathological anatomy in those cases where excretory urography and retrograde pyelography are unsatisfactory. No significant complications were encountered.

Fistula↗