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Biomedical subjects

S Goto

Publications and source records attributed to S Goto.

At least 973 records · Page 54Linked to original sources
PubMed1985

MRL/Mp-lpr/lpr mouse derived monoclonal antibodies that recognise determinants shared by poly (ADP-ribose), single stranded DNA and left handed Z-DNA.

MRL/Mp-lpr/lpr (MRL/l) mice spontaneously produce antibodies to poly(ADP-ribose) that are cross-reactive with single stranded DNA (ssDNA). Spleen cells from these animals were used for fusion with murine plasmacytoma cells to prepare hybridomas that produce autoantibodies to poly(ADP-ribose). Monoclonal antibodies (MoAb) produced by the selected hybridomas not only preferred ssDNA to poly(ADP-ribose), but also reacted with left handed Z-DNA; the MoAb reflected the nature of serum antibodies to poly (ADP-ribose) in MRL/l mice. These results suggest that similar antigenic determinants exist in poly (ADP-ribose), ssDNA and left handed Z-DNA and that the cross-reactive nature of autoantibodies to poly (ADP-ribose) in MRL/l mice may be the results of expansion of such clones as selected in this experiment.

Animals↗
PubMed1985

Radioimmunolocalization of monoclonal antibodies to human chorionic gonadotropin in choriocarcinoma transplanted into athymic mice.

Radioimmunodetection of monoclonal antibodies to human Chorionic Gonadotropin (hCG) or its beta-subunit in choriocarcinoma tissue was investigated in athymic mouse model system. Antibody to hCG exhibited a higher localization index (L.I.) in tumor tissue than those in other organs, but the tissue/blood ratio of this antibody in tumor tissue was not so high as expected (0.38 and 0.5 on Day 2 and 5 respectively). On the other hand, antibody to beta-subunit showed the same L.I. in tumor tissue as those in other organs. Gel filtration of serum of mouse given an antibody to hCG showed that the antibody was forming immune complexes in the blood stream. Autoradiography showed many grains in the capillary vessels and intercellular spaces in the tumor tissue. We concluded that a monoclonal antibody to hCG localized in choriocarcinoma tissue via a mechanism of retention of immune complexes in the tissue, and that there may be a limitation to the clinical application of localization of antibodies to secretory products such as hCG of tumor cells from their low specific localization.

Animals↗
PubMed1985

[Multidisciplinary treatment of choriocarcinoma].

The remarkable improvement has been recently made in the treatment of choriocarcinoma, about 80% of survival rate has been achieved. This improvement was acquired according to appearance and betterment on administration method of MTX and ACTG, surgical treatment for pulmonary and cerebral metastases and irradiation for cerebral metastases. Recent died cases were analysed and divided into two groups; one group consisted of recurrent cases and the other consisted of those who, at first showed good response to therapy resulted in drop of hCG value and reduction of tumor, however, then showed gradual reincrease of hCG and expired at latt. Therefore for achieving the 0% of mortality rate, it is a important subject to exterminate the death from recurrence and clarify more aggressive treatment method at the time when reduction of the tumor is obtained.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1985

[Comparison of in vitro antibacterial activities of new cephems against clinical organisms (isolated between June 1983 and January 1984)].

We compared the in vitro antibacterial activities of ceftizoxime (CZX), cefotaxime (CTX), cefmenoxime (CMX), cefoperazone (CPZ), ceftazidime (CAZ), latamoxef (LMOX) and cefotetan (CTT) against 2,729 strains of 11 organisms freshly isolated from 10 medical institutions in Japan between June 1983 and January 1984 and obtained the following results: Against S. pyogenes, LMOX and CTT, which have the methoxy group at the 7 position, were less active than the other drugs. LMOX inhibited 80% of S. pyogenes at 0.78 micrograms/ml; CTT, at 1.56 micrograms/ml; but CZX and CTX inhibited 100% at 0.025 micrograms/ml or lower; CMX, at 0.05 micrograms/ml; and CPZ and CAZ, at 0.20 micrograms/ml. Against H. influenzae, E. coli, K. pneumoniae, P. mirabilis and indole-positive Proteus, these test antibiotics, especially CZX, CTX and CMX, which have the aminothiazolyl methoxyimino group, were potently active. Against S. marcescens CZX and CAZ were more active than the other drugs and against P. aeruginosa CAZ was more active than the other drugs. The test organisms did not tend to acquire resistance to these cephems when our results were compared with the results obtained at the development period.

Bacteria↗
PubMed1985

[On interrupted postmolar choriocarcinoma].

It is extremely difficult to specify which pregnancy is responsible for gestational choriocarcinoma. Generally an antecedent pregnancy, directly preceding choriocarcinoma, is thought to be responsible for it. We have seen not a few cases of choriocarcinoma that had an obstetrical history of previous molar pregnancy preceding antecedent pregnancy. In such cases, responsibility not of the antecedent non-molar pregnancy but of the previous molar pregnancy is highly suspect in choriocarcinoma. In Niigata prefecture which has a population of 2.5 millions, we have reported 1,573 cases of total hydatidiform mole and 61 cases of choriocarcinoma in the past 12 years to the Regional Trophoblastic Disease Center. There were 8 cases of interrupted postmolar choriocarcinoma. The antecedent pregnancy was term delivery in 6 cases and abortion in 2 cases. It was of special interest to note that most of the interrupted postmolar choriocarcinoma were anteceded by term delivery with a previous history of hydatidiform mole. With the aid of statistics of pregnancy, delivery and trophoblastic disease in Niigata prefecture in the period of the survey, delivery with a previous history of hydatidiform mole was calculated to have 290 times as high risk of choriocarcinoma as that without a history of hydatidiform mole. Recently intraplacental choriocarcinoma with either living or, at times, stillborn baby has been reported occasionally. Most of the placenta reported in those cases showed no adverse effect on the growth of the fetus and no gross abnormality. Mostly intraplacental choriocarcinomatous lesion was detected incidentally or by minute histological examination of the placenta. From these results we emphasize the need to have a careful gross as well as microscopic examination of the placenta in case of a parturient with a previous history of hydatidiform mole and who has a higher risk for choriocarcinoma.

Adult↗