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Biomedical subjects

S Goldstein

Publications and source records attributed to S Goldstein.

At least 649 records · Page 36Linked to original sources
PubMed1974

Adenosine 3': 5'-cyclic monophosphate in young and senescent human fibroblasts during growth and stationary phase in vitro. Effects of prostaglandine E1 and of adrenaline.

Cyclic AMP levels per mg of cell protein were higher in late-passage (senescent) fibroblasts than in early-passage (young) fibroblasts both during growth and stationary phase, but, because the protein concentration per unit volume in senescent cells was lower than in young cells, the molar concentrations of intracellular cyclic AMP were very similar in the two cell types. In both young and senescent fibroblasts cyclic AMP levels declined during growth and no increase in intracellular cyclic AMP occurred in association with density-dependent inhibition of growth. These results indicate that changes in cyclic AMP concentration do not play a role in controlling the growth or in the senescent decline of human fibroblasts. Prostaglandin E(1) (1mum) caused maximal increases in fibroblast cyclic AMP concentration of 60-500-fold after 10-30min, and adrenaline (epinephrine) (10mum) caused maximum increases of 5-25-fold after 2-10min, depending on both the number of passages and the period after subculture. The cyclic AMP level in confluent young cells increased more with prostaglandin E(1) and far less with adrenaline than the cyclic AMP level in confluent senescent cells. During growth to confluence the cyclic AMP response to adrenaline declined in young cells and increased in senescent cells. As these responses to prostaglandin E(1) and to adrenaline changed independently of each other and of the basal cyclic AMP concentration, it is suggested that the expression of hormone receptors is altered both during growth to confluence and during senescence of human fibroblasts.

Adult↗
PubMed1973

Community psychiatry and the elderly.

An account is given of the first year's experience in providing psychogeriatric service to a large urban community. Patients were attended in their homes, in nursing homes and in Homes for the Aged. There was a tendency for the consultant's help to be sought mainly in cases of "disposal" of difficult patients rather than for treatment of the many who could be expected to benefit from it. However, the advantage has been demonstrated of continuity of service in the variety of settings and, as a result, the more proper placement of patients. Acceptance of the help the psychogeriatrician can contribute will inevitably increase, but demands the provision of improved day-care and day-hospital facilities.

Adjustment Disorders↗